Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

Resequencing of genes from individuals of European and African American ancestry indicates that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years, and that European Americans carry an excess of deleterious vari...

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Bibliographic Details
Published in:	Nature (London) Vol. 493; no. 7431; pp. 216 - 220
Main Authors:	Fu, Wenqing, O’Connor, Timothy D., Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M., Gabriel, Stacey, Rieder, Mark J., Altshuler, David, Shendure, Jay, Nickerson, Deborah A., Bamshad, Michael J., NHLBI Exome Sequencing Project, Akey, Joshua M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.01.2013 Nature Publishing Group
Subjects:	631/208/182 631/208/726/649 Africa - ethnology African Americans Age Alleles Black or African American Black People - genetics Europe - ethnology Evolution Evolution & development Evolution, Molecular Exome - genetics Exons - genetics Gene mutations Genetic diversity Genetic variance Genetic variation Genetic Variation - genetics Human populations Humanities and Social Sciences Humans letter Methods multidisciplinary Mutation Open Reading Frames - genetics Physiological aspects Polymorphism, Single Nucleotide - genetics Population genetics Population growth Principal components analysis Proteins Quality control Science Studies United States White People - genetics United States Europe Africa
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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