Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

Resequencing of genes from individuals of European and African American ancestry indicates that approximately 73% of all protein-coding SNVs and approximately 86% of SNVs predicted to be deleterious arose in the past 5,000–10,000 years, and that European Americans carry an excess of deleterious vari...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature (London) Ročník 493; číslo 7431; s. 216 - 220
Hlavní autoři:	Fu, Wenqing, O’Connor, Timothy D., Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M., Gabriel, Stacey, Rieder, Mark J., Altshuler, David, Shendure, Jay, Nickerson, Deborah A., Bamshad, Michael J., NHLBI Exome Sequencing Project, Akey, Joshua M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 10.01.2013 Nature Publishing Group
Témata:	631/208/182 631/208/726/649 Africa - ethnology African Americans Age Alleles Black or African American Black People - genetics Europe - ethnology Evolution Evolution & development Evolution, Molecular Exome - genetics Exons - genetics Gene mutations Genetic diversity Genetic variance Genetic variation Genetic Variation - genetics Human populations Humanities and Social Sciences Humans letter Methods multidisciplinary Mutation Open Reading Frames - genetics Physiological aspects Polymorphism, Single Nucleotide - genetics Population genetics Population growth Principal components analysis Proteins Quality control Science Studies United States White People - genetics United States Europe Africa
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!