Human B-cell isotype switching origins of IgE

B cells expressing IgE contribute to immunity against parasites and venoms and are the source of antigen specificity in allergic patients, yet the developmental pathways producing these B cells in human subjects remain a subject of debate. Much of our knowledge of IgE lineage development derives fro...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 137; no. 2; pp. 579 - 586.e7
Main Authors:	Looney, Timothy J., Lee, Ji-Yeun, Roskin, Krishna M., Hoh, Ramona A., King, Jasmine, Glanville, Jacob, Liu, Yi, Pham, Tho D., Dekker, Cornelia L., Davis, Mark M., Boyd, Scott D.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2016 Elsevier Limited
Subjects:	Adult Aged Aged, 80 and over Allergies Allergy and Immunology antibody Antigens B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Sequence B cell Case-Control Studies Cluster Analysis Computational Biology - methods direct Female high-throughput DNA sequencing High-Throughput Nucleotide Sequencing Human subjects Humans Hypersensitivity - genetics Hypersensitivity - immunology IgE Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin E - genetics Immunoglobulin E - immunology Immunoglobulin Heavy Chains - genetics Immunoglobulin Isotypes - genetics Immunoglobulin Isotypes - immunology Immunoglobulins indirect Influenza isotype switching Library collections Male Middle Aged Molecular Sequence Annotation Molecular Sequence Data Mutation repertoire Sequence Alignment Somatic Hypermutation, Immunoglobulin Young Adult antibody indirect IgE direct repertoire IGH high-throughput DNA sequencing FR B cell CDR3 isotype switching Complementarity determining region 3 Immunoglobulin heavy chain gene Framework region
ISSN:	0091-6749, 1097-6825
Online Access:	Get full text
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