A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction

A robust serological test to detect neutralizing antibodies to SARS-CoV-2 is urgently needed to determine not only the infection rate, herd immunity and predicted humoral protection, but also vaccine efficacy during clinical trials and after large-scale vaccination. The current gold standard is the...

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Bibliographic Details
Published in:	Nature biotechnology Vol. 38; no. 9; pp. 1073 - 1078
Main Authors:	Tan, Chee Wah, Chia, Wan Ni, Qin, Xijian, Liu, Pei, Chen, Mark I-C, Tiu, Charles, Hu, Zhiliang, Chen, Vivian Chih-Wei, Young, Barnaby E, Sia, Wan Rong, Tan, Yee-Joo, Foo, Randy, Yi, Yongxiang, Lye, David C, Anderson, Danielle E, Wang, Lin-Fa
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.09.2020
Subjects:	ACE2 Angiotensin Angiotensin-Converting Enzyme 2 Antibodies Antibodies - immunology Antibodies - pharmacology Betacoronavirus - genetics Betacoronavirus - pathogenicity Binding Biosafety Clinical trials Containment Coronavirus Infections - genetics Coronavirus Infections - immunology Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 Enzymes Herd immunity Humans Humoral immunity Neutralization Neutralization Tests Neutralizing Pandemics Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - genetics Pneumonia, Viral - genetics Pneumonia, Viral - immunology Pneumonia, Viral - pathology Pneumonia, Viral - virology Protein Interaction Domains and Motifs - genetics Proteins Receptors SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike protein Vaccination Vaccine efficacy Vaccines Viral diseases Viruses
ISSN:	1087-0156, 1546-1696, 1546-1696
Online Access:	Get full text
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