Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Background Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer across...

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Vydané v:	BMC cancer Ročník 15; číslo 1; s. 415
Hlavní autori:	Mackenzie, Robertson, Kommoss, Stefan, Winterhoff, Boris J., Kipp, Benjamin R., Garcia, Joaquin J., Voss, Jesse, Halling, Kevin, Karnezis, Anthony, Senz, Janine, Yang, Winnie, Prigge, Elena-Sophie, Reuschenbach, Miriam, Doeberitz, Magnus Von Knebel, Gilks, Blake C., Huntsman, David G., Bakkum-Gamez, Jamie, McAlpine, Jessica N., Anglesio, Michael S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 19.05.2015 BioMed Central Ltd
Predmet:	Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - pathology Analysis Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma, Ovarian Epithelial Female Gene mutations Genetic aspects Genetics genomics and epigenetics Health Promotion and Disease Prevention High-Throughput Nucleotide Sequencing Humans Immunohistochemistry Medicine/Public Health Mutation Mutation Rate Neoplasm Staging Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Oncology Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology ras Proteins - genetics ras Proteins - metabolism Research Article Signal Transduction Surgical Oncology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Heterogeneity Next-generation sequencing Mucinous Ovarian BRAF KRAS TP53
ISSN:	1471-2407, 1471-2407
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