Increased DNA methylation variability in type 1 diabetes across three immune effector cell types

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for...

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Published in:	Nature communications Vol. 7; no. 1; pp. 13555 - 11
Main Authors:	Paul, Dirk S., Teschendorff, Andrew E., Dang, Mary A.N., Lowe, Robert, Hawa, Mohammed I., Ecker, Simone, Beyan, Huriya, Cunningham, Stephanie, Fouts, Alexandra R., Ramelius, Anita, Burden, Frances, Farrow, Samantha, Rowlston, Sophia, Rehnstrom, Karola, Frontini, Mattia, Downes, Kate, Busche, Stephan, Cheung, Warren A., Ge, Bing, Simon, Marie-Michelle, Bujold, David, Kwan, Tony, Bourque, Guillaume, Datta, Avik, Lowy, Ernesto, Clarke, Laura, Flicek, Paul, Libertini, Emanuele, Heath, Simon, Gut, Marta, Gut, Ivo G, Ouwehand, Willem H., Pastinen, Tomi, Soranzo, Nicole, Hofer, Sabine E., Karges, Beate, Meissner, Thomas, Boehm, Bernhard O., Cilio, Corrado, Elding Larsson, Helena, Lernmark, Åke, Steck, Andrea K., Rakyan, Vardhman K., Beck, Stephan, Leslie, R. David
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 29.11.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/208/177 631/208/248/144 692/699/2743/137/1418 Biology Cancer Cell cycle Cell division Clinical Medicine College campuses CpG Islands - genetics Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Disease Disease genetics DNA methylation DNA Methylation - genetics Endocrinology Endocrinology and Diabetes Endokrinologi och diabetes Epigenetics Epigenomics Fetal Blood - metabolism Gene expression Genetic factors Genomes Genomics Health care Humanities and Social Sciences Humans Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Medicine Molecular Sequence Annotation multidisciplinary Pathogenesis Pediatrics Science Science (multidisciplinary) Time Factors Twins, Monozygotic - genetics Type 1 diabetes Canada Montreal Quebec Canada Singapore United Kingdom > UK Germany Spain
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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