The structure of human thyroglobulin

Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates 1 , 2 . Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteo...

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Bibliographic Details
Published in:	Nature (London) Vol. 578; no. 7796; pp. 627 - 630
Main Authors:	Coscia, Francesca, Taler-Verčič, Ajda, Chang, Veronica T., Sinn, Ludwig, O’Reilly, Francis J., Izoré, Thierry, Renko, Miha, Berger, Imre, Rappsilber, Juri, Turk, Dušan, Löwe, Jan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 27.02.2020 Nature Publishing Group
Subjects:	101/1 101/28 101/58 631/45/173 631/535/1258/1259 692/163/2743 82/80 82/83 Bacterial Proteins - chemistry Coupling Cryoelectron Microscopy Drug resistance Electron microscopy HEK293 Cells Hormones Humanities and Social Sciences Humans Iodination Maltose Maltose-binding protein Maltose-Binding Proteins - chemistry Mass spectrometry Metabolism Microscopy Models, Molecular multidisciplinary Mutation Physiological aspects Proteins Reproducibility of Results Science Science (multidisciplinary) Scientific imaging Site-directed mutagenesis Solvents - chemistry Structure Thyroglobulin Thyroglobulin - chemistry Thyroglobulin - genetics Thyroglobulin - ultrastructure Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - biosynthesis Thyroid Hormones - metabolism Tyrosine Tyrosine - chemistry Tyrosine - genetics Tyrosine - metabolism United Kingdom
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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