3 ′-5 ′ crosstalk contributes to transcriptional bursting

Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contribu...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Genome Biology Ročník 22; číslo 1; s. 56
Hlavní autori: Cavallaro, Massimo, Walsh, Mark D., Jones, Matt, Teahan, James, Tiberi, Simone, Finkenstädt, Bärbel, Hebenstreit, Daniel
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 04.02.2021
Springer Nature B.V
BMC
Predmet:
Animal Genetics and Genomics
Animals
Bayes Theorem
Bayesian analysis
Bayesian theory
beta-Globins - genetics
Bioinformatics
Biological noise
Biomedical and Life Sciences
Burst size
Cell cycle
Cell Physiological Phenomena
Evolutionary Biology
Gene Expression
Gene looping
Genomes
HEK293 Cells
Human Genetics
Humans
Life Sciences
Liquid-liquid phase separation
liquids
Mammalian cells
mammals
Mathematical modelling
Microbial Genetics and Genomics
Models, Genetic
Models, Theoretical
Morphology
Mutation
Parameter inference
Plant Genetics and Genomics
RNA polymerase
RNA, Messenger
Stochastic Processes
transcription (genetics)
Transcription factors
Transcription termination
Transcription, Genetic
Transgenes
Mathematical modelling
Liquid-liquid phase separation
Gene expression
Gene looping
Parameter inference
Biological noise
ISSN:1474-760X, 1474-7596, 1474-760X
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment. Conclusions Interactions between the 3 ′ and 5 ′ ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
AbstractList BACKGROUND: Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. RESULTS: Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment. CONCLUSIONS: Interactions between the 3 ′ and 5 ′ ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 and 5 ends of a gene that enable reinitiation of transcription upon termination. Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment. Interactions between the 3 and 5 ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ' and 5 ' ends of a gene that enable reinitiation of transcription upon termination.BACKGROUNDTranscription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ' and 5 ' ends of a gene that enable reinitiation of transcription upon termination.Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment.RESULTSUsing Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment.Interactions between the 3 ' and 5 ' ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.CONCLUSIONSInteractions between the 3 ' and 5 ' ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment. Conclusions Interactions between the 3 ′ and 5 ′ ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bayesian methodology, we measure the transcriptional bursting in inducible transgenes, showing that perturbation of polymerase shuttling typically reduces burst size, increases burst frequency, and thus limits transcriptional noise. Analysis based on paired-end tag sequencing (PolII ChIA-PET) suggests that this effect is genome wide. The observed noise patterns are also reproduced by a generative model that captures major characteristics of the polymerase flux between the ends of a gene and a phase-separated compartment. Conclusions Interactions between the 3 ′ and 5 ′ ends of a gene, which facilitate polymerase recycling, are major contributors to transcriptional noise.
ArticleNumber 56
Author Cavallaro, Massimo
Jones, Matt
Teahan, James
Hebenstreit, Daniel
Walsh, Mark D.
Tiberi, Simone
Finkenstädt, Bärbel
Author_xml – sequence: 1
  givenname: Massimo
  orcidid: 0000-0002-2365-6024
  surname: Cavallaro
  fullname: Cavallaro, Massimo
  email: m.cavallaro@warwick.ac.uk
  organization: School of Life Sciences, University of Warwick, Mathematics Institute and Zeeman Institute for Systems Biology and Infectious Disease Epidemiology Research, University of Warwick, Department of Statistics, University of Warwick
– sequence: 2
  givenname: Mark D.
  surname: Walsh
  fullname: Walsh, Mark D.
  organization: School of Life Sciences, University of Warwick
– sequence: 3
  givenname: Matt
  surname: Jones
  fullname: Jones, Matt
  organization: School of Life Sciences, University of Warwick
– sequence: 4
  givenname: James
  surname: Teahan
  fullname: Teahan, James
  organization: Department of Chemistry, University of Warwick
– sequence: 5
  givenname: Simone
  surname: Tiberi
  fullname: Tiberi, Simone
  organization: Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich
– sequence: 6
  givenname: Bärbel
  surname: Finkenstädt
  fullname: Finkenstädt, Bärbel
  organization: Department of Statistics, University of Warwick
– sequence: 7
  givenname: Daniel
  surname: Hebenstreit
  fullname: Hebenstreit, Daniel
  email: d.hebenstreit@warwick.ac.uk
  organization: School of Life Sciences, University of Warwick
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33541397$$D View this record in MEDLINE/PubMed
BookMark eNqFUkluFDEUtVAQGeACLFBJbNhU8Fi2FyChiCFSJDYgsbO-3a7GTXW5sV1I7DgTR-IkuLqSkGQRFp7fe_7DO0YHYxw9Qk8JPiVEdS8zYVjoFlNcB6WyFQ_QEeGSt7LDXw5u7A_Rcc4bjInmtHuEDhkTnDAtj9Ar1vz59bsV89y4FHMuMHxrXBxLCnYqPjclNiXBmF0KuxLiCENjp5RLGNeP0cMehuyfXK4n6PO7t5_OPrQXH9-fn725aJ3EqrSWcG57JcHjXlvcWempFyvFesU04I5ZXs_USa9Ij8ErTHux0uCAAmOEsxN0vuiuImzMLoUtpJ8mQjD7i5jWBlIJbvBGS8K854xaxXknOKzAMuCCdsx1Guuq9XrR2k1261fO10xhuCV6-2UMX806_jBSdRhzUQVeXAqk-H3yuZhtyM4PA4w-TtlQIYiWXGryfyhXkghFlKzQ53egmzilWuwZpQnVjGFcUc9uBn8d9VVDK4AugH0vk--vIQSb2TVmcY2prjF715g5I3WH5EKBude1AGG4n8oWaq7_jGuf_oV9D-sv2DvWiA
CitedBy_id crossref_primary_10_1016_j_jmb_2024_168690
crossref_primary_10_1016_j_isci_2024_109914
crossref_primary_10_1093_bib_bbab563
crossref_primary_10_1371_journal_pcbi_1010152
crossref_primary_10_1098_rsos_221469
crossref_primary_10_1186_s13059_023_02977_y
crossref_primary_10_3390_v15102119
crossref_primary_10_1002_cyto_a_24924
crossref_primary_10_1042_BST20231286
crossref_primary_10_3390_v16040615
crossref_primary_10_1093_nar_gkaf184
crossref_primary_10_1093_bib_bbab148
crossref_primary_10_1111_febs_16250
Cites_doi 10.1002/cyto.a.20531
10.1038/nprot.2013.143
10.1126/science.1188308
10.1038/nature09326
10.1016/j.molcel.2007.11.035
10.1016/j.cub.2006.03.092
10.1126/science.aar4199
10.1016/j.cell.2009.02.001
10.1126/science.1070919
10.5281/zenodo.4304833
10.1016/j.molcel.2016.03.007
10.1128/MCB.18.10.5992
10.1016/j.molcel.2011.11.035
10.1016/j.cell.2015.04.044
10.1371/journal.pone.0158298
10.1103/PhysRevE.92.022137
10.1126/science.aau4795
10.1186/s13059-014-0550-8
10.1093/bioinformatics/bty568
10.1038/s41556-020-00578-6
10.2307/3001536
10.1126/science.aar2555
10.1186/1471-2105-10-106
10.1126/science.1216379
10.1371/journal.pone.0156132
10.1529/biophysj.106.086157
10.1093/bioinformatics/btq033
10.1016/j.molcel.2010.10.012
10.1093/bioinformatics/btu638
10.1186/1471-2105-10-145
10.5281/zenodo.4127058
10.1371/journal.pcbi.1004972
10.1186/s13059-019-1861-6
10.7554/eLife.32303
10.1126/science.1098641
10.1126/science.aar3958
10.14806/ej.17.1.200
10.1126/science.1239053
10.1038/ncomms5761
10.1016/j.cell.2015.11.018
10.1038/s41586-019-1165-8
10.1002/0471722731
10.3389/fmicb.2016.00479
10.1038/nature04785
10.1016/j.cell.2005.09.031
10.1038/s41586-018-0836-1
10.1371/journal.pone.0106040
10.1016/j.cell.2017.02.007
10.1126/science.1114383
10.1371/journal.pbio.0040309
10.1101/gad.1362305
10.7554/eLife.12175
10.1016/j.molcel.2007.11.030
10.7554/eLife.13617
10.1038/ng1051
10.1016/j.celrep.2018.04.047
10.1016/j.cels.2015.10.011
10.1093/nar/gku365
10.1016/j.molcel.2015.03.005
10.1038/s41586-019-1517-4
10.1016/j.cub.2010.01.052
10.1016/S1097-2765(02)00781-5
10.7717/peerj.6222
10.1186/gb-2013-14-1-r7
10.1093/nar/gkw809
10.1016/j.bpj.2010.03.001
10.1016/j.molcel.2012.05.008
10.1126/science.1224350
10.1126/science.1198817
10.1038/s41587-019-0379-5
10.1371/journal.pcbi.1003161
10.1038/nrm3098
10.1101/514174
10.1016/j.cell.2016.05.025
10.1038/nature08504
10.1093/nar/gkz114
10.1093/nar/gkq091
10.1038/s41594-018-0112-y
10.1016/j.cell.2018.10.057
10.1073/pnas.0803507106
10.1016/j.cell.2011.12.014
10.1038/s41594-018-0124-7
10.18637/jss.v035.i04
10.1016/j.tig.2013.04.001
10.1093/bioinformatics/bts635
10.1371/journal.pone.0140969
10.1021/cr300513p
10.1038/ng1807
10.1038/nsmb.1514
10.1016/j.cell.2014.05.038
ContentType Journal Article
Copyright The Author(s) 2021
2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: 2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
7S9
L.6
5PM
DOA
DOI 10.1186/s13059-020-02227-5
DatabaseName Springer Nature OA Free Journals (Selected full-text)
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials - QC
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA
Publicly Available Content Database
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1474-760X
EndPage 56
ExternalDocumentID oai_doaj_org_article_9713ee432b844654adab3a45263c6909
PMC7860045
33541397
10_1186_s13059_020_02227_5
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Biotechnology and Biological Sciences Research Council (GB)
  grantid: BB/M017982/1
– fundername: Biotechnology and Biological Sciences Research Council
  grantid: BB/L006340/1
  funderid: http://dx.doi.org/10.13039/501100000268
– fundername: Biotechnology and Biological Sciences Research Council
  grantid: BB/M017982/1
– fundername: Biotechnology and Biological Sciences Research Council
  grantid: BB/L006340/1
– fundername: ;
  grantid: BB/L006340/1
– fundername: ;
  grantid: BB/M017982/1
GroupedDBID ---
0R~
29H
4.4
53G
5GY
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAHBH
AAJSJ
AASML
ABUWG
ACGFO
ACGFS
ACJQM
ACPRK
ADBBV
ADUKV
AEGXH
AFKRA
AFPKN
AHBYD
AIAGR
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIAM
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C6C
CCPQU
EBD
EBLON
EBS
EMOBN
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
IAO
IGS
IHR
ISR
ITC
KPI
LK8
M1P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PUEGO
ROL
RPM
RSV
SJN
SOJ
SV3
UKHRP
AAYXX
AFFHD
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PKEHL
PQEST
PQUKI
PRINS
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-c708t-b144bf87ae0f9b06b7e2e5d83f839a063b42e52c7e81f0ae802f5d9aca2a33143
IEDL.DBID DOA
ISICitedReferencesCount 14
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000614923400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1474-760X
1474-7596
IngestDate Fri Oct 03 12:44:37 EDT 2025
Tue Nov 04 01:40:35 EST 2025
Wed Oct 01 14:46:14 EDT 2025
Wed Oct 01 14:16:00 EDT 2025
Tue Oct 14 12:41:33 EDT 2025
Mon Jul 21 05:35:34 EDT 2025
Sat Nov 29 04:55:56 EST 2025
Tue Nov 18 22:26:22 EST 2025
Sat Sep 06 07:17:34 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Mathematical modelling
Liquid-liquid phase separation
Gene expression
Gene looping
Parameter inference
Biological noise
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c708t-b144bf87ae0f9b06b7e2e5d83f839a063b42e52c7e81f0ae802f5d9aca2a33143
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-2365-6024
OpenAccessLink https://doaj.org/article/9713ee432b844654adab3a45263c6909
PMID 33541397
PQID 2491293300
PQPubID 2040232
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_9713ee432b844654adab3a45263c6909
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7860045
proquest_miscellaneous_2551974791
proquest_miscellaneous_2487158187
proquest_journals_2491293300
pubmed_primary_33541397
crossref_primary_10_1186_s13059_020_02227_5
crossref_citationtrail_10_1186_s13059_020_02227_5
springer_journals_10_1186_s13059_020_02227_5
PublicationCentury 2000
PublicationDate 2021-02-04
PublicationDateYYYYMMDD 2021-02-04
PublicationDate_xml – month: 02
  year: 2021
  text: 2021-02-04
  day: 04
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Genome Biology
PublicationTitleAbbrev Genome Biol
PublicationTitleAlternate Genome Biol
PublicationYear 2021
Publisher BioMed Central
Springer Nature B.V
BMC
Publisher_xml – name: BioMed Central
– name: Springer Nature B.V
– name: BMC
References SO Skinner (2227_CR11) 2016; 5
I Golding (2227_CR1) 2005; 123
MJ Moore (2227_CR31) 2009; 136
WK Cho (2227_CR27) 2018; 361
AB Russell (2227_CR79) 2018; 7
A Raj (2227_CR4) 2006; 4
CK Mapendano (2227_CR33) 2010; 40
DLV Bauer (2227_CR81) 2018; 23
JM Raser (2227_CR14) 2004; 304
D Hnisz (2227_CR40) 2017; 169
RD Dar (2227_CR67) 2015; 10
JN Kuehner (2227_CR32) 2011; 12
N Battich (2227_CR13) 2015; 163
V Svensson (2227_CR77) 2020; 38
K Lo (2227_CR56) 2008; 73A
WK Cho (2227_CR22) 2016; 5
A Ansari (2227_CR42) 2005; 19
CK Damgaard (2227_CR36) 2008; 29
A Reik (2227_CR38) 1998; 18
DM Suter (2227_CR3) 2011; 332
KF Murphy (2227_CR86) 2010; 38
L Bandiera (2227_CR87) 2016; 7
F Ramírez (2227_CR51) 2014; 42
D Hebenstreit (2227_CR35) 2013; 29
M Soltani (2227_CR68) 2016; 12
N Zhao (2227_CR80) 2018; 25
MB Elowitz (2227_CR8) 2002; 297
JR Chubb (2227_CR2) 2006; 16
2227_CR89
L Weinberger (2227_CR15) 2012; 47
FW Townes (2227_CR78) 2019; 20
AJ Plys (2227_CR23) 2018; 361
HJE Beaumont (2227_CR85) 2009; 462
A Papantonis (2227_CR20) 2013; 113
K Lo (2227_CR58) 2009; 10
J Kim (2227_CR61) 2013; 14
G Li (2227_CR74) 2012; 148
S Chong (2227_CR17) 2014; 158
MS Sherman (2227_CR10) 2015; 1
D Zenklusen (2227_CR63) 2008; 15
O Padovan-Merhar (2227_CR12) 2015; 58
A Bar-Even (2227_CR69) 2006; 38
CJ Zopf (2227_CR9) 2013; 9
Y Wang (2227_CR41) 2010; 20
A Singh (2227_CR6) 2010; 98
FA Ran (2227_CR60) 2013; 8
S Tiberi (2227_CR59) 2018; 34
2227_CR90
M Dobrzynski (2227_CR62) 2009; 106
2227_CR91
Y Taniguchi (2227_CR71) 2010; 329
KJ Perkins (2227_CR45) 2008; 29
MT Wei (2227_CR30) 2020; 22
S Wani (2227_CR43) 2014; 9
M Martin (2227_CR46) 2011; 17
S Yang (2227_CR73) 2014; 5
NP Dyer (2227_CR49) 2019; 7
AM Klein (2227_CR64) 2015; 161
JRS Newman (2227_CR70) 2006; 441
S Anders (2227_CR50) 2015; 31
T Fukaya (2227_CR18) 2016; 166
HM Shapiro (2227_CR55) 2003
Y Liao (2227_CR54) 2019; 47
C Bartman (2227_CR19) 2016; 62
B Munsky (2227_CR5) 2012; 336
B Tolhuis (2227_CR39) 2002; 10
II Cisse (2227_CR21) 2013; 341
Y Shin (2227_CR29) 2018; 175
MI Love (2227_CR52) 2014; 15
E Kussell (2227_CR83) 2005; 309
SM Tan-Wong (2227_CR44) 2012; 338
RD Dar (2227_CR66) 2016; 11
A Dobin (2227_CR48) 2013; 29
AJM Larsson (2227_CR7) 2019; 565
A Patil (2227_CR88) 2010; 35
JS van Zon (2227_CR16) 2006; 91
2227_CR65
G Li (2227_CR75) 2017; 45
F Hahne (2227_CR57) 2009; 10
J Stewart-Ornstein (2227_CR72) 2012; 45
A Eldar (2227_CR84) 2010; 467
M Cavallaro (2227_CR82) 2015; 92
P Cramer (2227_CR28) 2019; 573
AR Quinlan (2227_CR47) 2010; 26
MS Bartlett (2227_CR76) 1947; 3
BR Sabari (2227_CR26) 2018; 361
X Fang (2227_CR34) 2019; 569
D Carter (2227_CR37) 2002; 32
M Boehning (2227_CR24) 2018; 25
LD Goldstein (2227_CR53) 2016; 11
S Chong (2227_CR25) 2018; 361
References_xml – volume: 73A
  start-page: 321
  issue: 4
  year: 2008
  ident: 2227_CR56
  publication-title: Cytom Part A
  doi: 10.1002/cyto.a.20531
– volume: 8
  start-page: 2281
  issue: 11
  year: 2013
  ident: 2227_CR60
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2013.143
– volume: 329
  start-page: 533
  issue: 5991
  year: 2010
  ident: 2227_CR71
  publication-title: Science
  doi: 10.1126/science.1188308
– volume: 467
  start-page: 167
  issue: 7312
  year: 2010
  ident: 2227_CR84
  publication-title: Nature
  doi: 10.1038/nature09326
– volume: 29
  start-page: 271
  issue: 2
  year: 2008
  ident: 2227_CR36
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2007.11.035
– volume: 16
  start-page: 1018
  issue: 10
  year: 2006
  ident: 2227_CR2
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2006.03.092
– volume: 361
  start-page: 412
  issue: 6400
  year: 2018
  ident: 2227_CR27
  publication-title: Science
  doi: 10.1126/science.aar4199
– volume: 136
  start-page: 688
  issue: 4
  year: 2009
  ident: 2227_CR31
  publication-title: Cell
  doi: 10.1016/j.cell.2009.02.001
– volume: 297
  start-page: 1183
  issue: 5584
  year: 2002
  ident: 2227_CR8
  publication-title: Science
  doi: 10.1126/science.1070919
– ident: 2227_CR90
  doi: 10.5281/zenodo.4304833
– volume: 62
  start-page: 237
  issue: 2
  year: 2016
  ident: 2227_CR19
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2016.03.007
– volume: 18
  start-page: 5992
  issue: 10
  year: 1998
  ident: 2227_CR38
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.18.10.5992
– volume: 45
  start-page: 483
  issue: 4
  year: 2012
  ident: 2227_CR72
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2011.11.035
– volume: 161
  start-page: 1187
  issue: 5
  year: 2015
  ident: 2227_CR64
  publication-title: Cell
  doi: 10.1016/j.cell.2015.04.044
– volume: 11
  start-page: 0158298
  issue: 7
  year: 2016
  ident: 2227_CR66
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0158298
– volume: 92
  start-page: 022137
  issue: 2
  year: 2015
  ident: 2227_CR82
  publication-title: Phys Rev E
  doi: 10.1103/PhysRevE.92.022137
– volume: 361
  start-page: 329
  issue: 6400
  year: 2018
  ident: 2227_CR23
  publication-title: Science
  doi: 10.1126/science.aau4795
– volume: 15
  start-page: 550
  issue: 12
  year: 2014
  ident: 2227_CR52
  publication-title: Genome Biol
  doi: 10.1186/s13059-014-0550-8
– volume: 34
  start-page: 647
  issue: 17
  year: 2018
  ident: 2227_CR59
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bty568
– volume: 22
  start-page: 1187
  issue: 10
  year: 2020
  ident: 2227_CR30
  publication-title: Nat Cell Biol
  doi: 10.1038/s41556-020-00578-6
– volume: 3
  start-page: 39
  issue: 1
  year: 1947
  ident: 2227_CR76
  publication-title: Biometrics
  doi: 10.2307/3001536
– volume: 361
  start-page: 2555
  issue: 6400
  year: 2018
  ident: 2227_CR25
  publication-title: Science
  doi: 10.1126/science.aar2555
– volume: 10
  start-page: 106
  year: 2009
  ident: 2227_CR57
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-10-106
– volume: 336
  start-page: 183
  issue: 6078
  year: 2012
  ident: 2227_CR5
  publication-title: Science
  doi: 10.1126/science.1216379
– volume: 11
  start-page: 0156132
  issue: 5
  year: 2016
  ident: 2227_CR53
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0156132
– volume: 91
  start-page: 4350
  issue: 12
  year: 2006
  ident: 2227_CR16
  publication-title: Biophys J
  doi: 10.1529/biophysj.106.086157
– volume: 26
  start-page: 841
  issue: 6
  year: 2010
  ident: 2227_CR47
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq033
– volume: 40
  start-page: 410
  issue: 3
  year: 2010
  ident: 2227_CR33
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2010.10.012
– volume: 31
  start-page: 166
  issue: 2
  year: 2015
  ident: 2227_CR50
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 10
  start-page: 145
  issue: 1
  year: 2009
  ident: 2227_CR58
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-10-145
– ident: 2227_CR89
  doi: 10.5281/zenodo.4127058
– volume: 12
  start-page: 1004972
  issue: 8
  year: 2016
  ident: 2227_CR68
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1004972
– volume: 20
  start-page: 295
  issue: 1
  year: 2019
  ident: 2227_CR78
  publication-title: Genome Biol
  doi: 10.1186/s13059-019-1861-6
– volume: 7
  start-page: e32303
  year: 2018
  ident: 2227_CR79
  publication-title: eLife
  doi: 10.7554/eLife.32303
– volume: 304
  start-page: 1811
  issue: 5678
  year: 2004
  ident: 2227_CR14
  publication-title: Science
  doi: 10.1126/science.1098641
– volume: 361
  start-page: 3958
  issue: 6400
  year: 2018
  ident: 2227_CR26
  publication-title: Science
  doi: 10.1126/science.aar3958
– volume: 17
  start-page: 10
  issue: 1
  year: 2011
  ident: 2227_CR46
  publication-title: EMBnet J
  doi: 10.14806/ej.17.1.200
– ident: 2227_CR65
– volume: 341
  start-page: 664
  issue: 6146
  year: 2013
  ident: 2227_CR21
  publication-title: Science
  doi: 10.1126/science.1239053
– volume: 5
  start-page: 4761
  issue: 1
  year: 2014
  ident: 2227_CR73
  publication-title: Nat Commun
  doi: 10.1038/ncomms5761
– volume: 163
  start-page: 1596
  issue: 7
  year: 2015
  ident: 2227_CR13
  publication-title: Cell
  doi: 10.1016/j.cell.2015.11.018
– volume: 569
  start-page: 265
  issue: 7755
  year: 2019
  ident: 2227_CR34
  publication-title: Nature
  doi: 10.1038/s41586-019-1165-8
– volume-title: Practical flow cytometry
  year: 2003
  ident: 2227_CR55
  doi: 10.1002/0471722731
– volume: 7
  start-page: 479
  year: 2016
  ident: 2227_CR87
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2016.00479
– volume: 441
  start-page: 840
  issue: 7095
  year: 2006
  ident: 2227_CR70
  publication-title: Nature
  doi: 10.1038/nature04785
– volume: 123
  start-page: 1025
  issue: 6
  year: 2005
  ident: 2227_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2005.09.031
– volume: 565
  start-page: 251
  issue: 7738
  year: 2019
  ident: 2227_CR7
  publication-title: Nature
  doi: 10.1038/s41586-018-0836-1
– volume: 9
  start-page: 106040
  issue: 8
  year: 2014
  ident: 2227_CR43
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0106040
– volume: 169
  start-page: 13
  issue: 1
  year: 2017
  ident: 2227_CR40
  publication-title: Cell
  doi: 10.1016/j.cell.2017.02.007
– volume: 309
  start-page: 2075
  issue: 5743
  year: 2005
  ident: 2227_CR83
  publication-title: Science
  doi: 10.1126/science.1114383
– volume: 4
  start-page: 309
  issue: 10
  year: 2006
  ident: 2227_CR4
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0040309
– volume: 19
  start-page: 2969
  issue: 24
  year: 2005
  ident: 2227_CR42
  publication-title: Genes Dev
  doi: 10.1101/gad.1362305
– volume: 5
  start-page: e12175
  year: 2016
  ident: 2227_CR11
  publication-title: eLife
  doi: 10.7554/eLife.12175
– volume: 29
  start-page: 56
  issue: 1
  year: 2008
  ident: 2227_CR45
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2007.11.030
– volume: 5
  start-page: e13617
  year: 2016
  ident: 2227_CR22
  publication-title: eLife
  doi: 10.7554/eLife.13617
– volume: 32
  start-page: 623
  issue: 4
  year: 2002
  ident: 2227_CR37
  publication-title: Nat Genet
  doi: 10.1038/ng1051
– volume: 23
  start-page: 2119
  issue: 7
  year: 2018
  ident: 2227_CR81
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2018.04.047
– volume: 1
  start-page: 315
  issue: 5
  year: 2015
  ident: 2227_CR10
  publication-title: Cell Syst
  doi: 10.1016/j.cels.2015.10.011
– volume: 42
  start-page: 187
  issue: Web Server issu
  year: 2014
  ident: 2227_CR51
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gku365
– volume: 58
  start-page: 339
  issue: 2
  year: 2015
  ident: 2227_CR12
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2015.03.005
– volume: 573
  start-page: 45
  issue: 7772
  year: 2019
  ident: 2227_CR28
  publication-title: Nature
  doi: 10.1038/s41586-019-1517-4
– volume: 20
  start-page: 548
  issue: 6
  year: 2010
  ident: 2227_CR41
  publication-title: Curr Biol CB
  doi: 10.1016/j.cub.2010.01.052
– volume: 10
  start-page: 1453
  issue: 6
  year: 2002
  ident: 2227_CR39
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(02)00781-5
– volume: 7
  start-page: 6222
  year: 2019
  ident: 2227_CR49
  publication-title: PeerJ
  doi: 10.7717/peerj.6222
– volume: 14
  start-page: 7
  issue: 1
  year: 2013
  ident: 2227_CR61
  publication-title: Genome Biol
  doi: 10.1186/gb-2013-14-1-r7
– volume: 45
  start-page: 4
  issue: 1
  year: 2017
  ident: 2227_CR75
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkw809
– volume: 98
  start-page: 32
  issue: 8
  year: 2010
  ident: 2227_CR6
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2010.03.001
– volume: 47
  start-page: 193
  issue: 2
  year: 2012
  ident: 2227_CR15
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.05.008
– volume: 338
  start-page: 671
  issue: 6107
  year: 2012
  ident: 2227_CR44
  publication-title: Science
  doi: 10.1126/science.1224350
– volume: 332
  start-page: 472
  issue: 6028
  year: 2011
  ident: 2227_CR3
  publication-title: Science
  doi: 10.1126/science.1198817
– volume: 38
  start-page: 147
  issue: 2
  year: 2020
  ident: 2227_CR77
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-019-0379-5
– volume: 9
  start-page: 1003161
  issue: 7
  year: 2013
  ident: 2227_CR9
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1003161
– volume: 12
  start-page: 283
  issue: 5
  year: 2011
  ident: 2227_CR32
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/nrm3098
– ident: 2227_CR91
  doi: 10.1101/514174
– volume: 166
  start-page: 358
  issue: 2
  year: 2016
  ident: 2227_CR18
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.025
– volume: 462
  start-page: 90
  issue: 7269
  year: 2009
  ident: 2227_CR85
  publication-title: Nature
  doi: 10.1038/nature08504
– volume: 47
  start-page: 47
  issue: 8
  year: 2019
  ident: 2227_CR54
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz114
– volume: 38
  start-page: 2712
  issue: 8
  year: 2010
  ident: 2227_CR86
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkq091
– volume: 25
  start-page: 833
  issue: 9
  year: 2018
  ident: 2227_CR24
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/s41594-018-0112-y
– volume: 175
  start-page: 1481
  issue: 6
  year: 2018
  ident: 2227_CR29
  publication-title: Cell
  doi: 10.1016/j.cell.2018.10.057
– volume: 106
  start-page: 2583
  issue: 8
  year: 2009
  ident: 2227_CR62
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0803507106
– volume: 148
  start-page: 84
  issue: 1-2
  year: 2012
  ident: 2227_CR74
  publication-title: Cell
  doi: 10.1016/j.cell.2011.12.014
– volume: 25
  start-page: 885
  issue: 9
  year: 2018
  ident: 2227_CR80
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/s41594-018-0124-7
– volume: 35
  start-page: 1
  issue: 4
  year: 2010
  ident: 2227_CR88
  publication-title: J Stat Softw
  doi: 10.18637/jss.v035.i04
– volume: 29
  start-page: 333
  issue: 6
  year: 2013
  ident: 2227_CR35
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2013.04.001
– volume: 29
  start-page: 15
  issue: 1
  year: 2013
  ident: 2227_CR48
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts635
– volume: 10
  start-page: 0140969
  issue: 10
  year: 2015
  ident: 2227_CR67
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0140969
– volume: 113
  start-page: 8683
  issue: 11
  year: 2013
  ident: 2227_CR20
  publication-title: Chem Rev
  doi: 10.1021/cr300513p
– volume: 38
  start-page: 636
  issue: 6
  year: 2006
  ident: 2227_CR69
  publication-title: Nat Genet
  doi: 10.1038/ng1807
– volume: 15
  start-page: 1263
  issue: 12
  year: 2008
  ident: 2227_CR63
  publication-title: Nat Struct Mol Biol
  doi: 10.1038/nsmb.1514
– volume: 158
  start-page: 314
  issue: 2
  year: 2014
  ident: 2227_CR17
  publication-title: Cell
  doi: 10.1016/j.cell.2014.05.038
SSID ssj0019426
ssj0017866
Score 2.4605536
Snippet Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid...
Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It...
Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid...
BACKGROUND: Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid...
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 56
SubjectTerms Animal Genetics and Genomics
Animals
Bayes Theorem
Bayesian analysis
Bayesian theory
beta-Globins - genetics
Bioinformatics
Biological noise
Biomedical and Life Sciences
Burst size
Cell cycle
Cell Physiological Phenomena
Evolutionary Biology
Gene Expression
Gene looping
Genomes
HEK293 Cells
Human Genetics
Humans
Life Sciences
Liquid-liquid phase separation
liquids
Mammalian cells
mammals
Mathematical modelling
Microbial Genetics and Genomics
Models, Genetic
Models, Theoretical
Morphology
Mutation
Parameter inference
Plant Genetics and Genomics
RNA polymerase
RNA, Messenger
Stochastic Processes
transcription (genetics)
Transcription factors
Transcription termination
Transcription, Genetic
Transgenes
SummonAdditionalLinks – databaseName: Biological Science Database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9YwDLZggLQL34zCQEXiBtXaJmmSA0KAmDigaQdAu1VJmowJ1I63HRI3fhM_iV-CnX5MLx_vhUulNGnlxLHzOHFsgMeBBRE4yrfVXGaU0TizDpVhsMaFwrlKxQCmH97KgwN1dKQPpw23fnKrnHViVNRN52iPfA_NBFqaWJ4_P_2SUdYoOl2dUmhchEsUJYFF173D5RRBKsIqU0HzcrxqRA6IQlfzDRpV7fWoyIXOyJKKd0MzsbZKxWD-f0OgfzpS_naaGhep_Wv_273rcHWCp-mLcT7dgAu-vQlXxoSV327BM5b-_P4jE_RMI-mI3T-l0d-dEmf5Ph26dKD1b9ZG-DfkW0_e1bfh_f7rd6_eZFMChszJXA2ZRWvLBiWNz4O2eWWlL71oFAsIqwyCG8uxXDrpVRFy41VeBtFo40xpGEMkdge22q71dyEtPNMOwYhFrcaldNo2TeCeM2m1cownUMwDXrspOjklyfhcRytFVfXIpBqZVEcm1SKBJ8s3p2Nsjo2tXxIfl5YUVzu-6FbH9SSmtUab3SNVpVUx0pxpjGWG0rAzV-lcJ7A7s6-ehL2vz3mXwKOlGsWUzl5M67szaoOWqUB0JDe0EXSLmEtdJLAzTqyFWsYEJ7CegFybcmvdWa9pTz7GcOEoBQTcE3g6T85z0v89XPc29_Q-bJfk3UP-63wXtobVmX8Al93X4aRfPYxi-Av3DjZa
  priority: 102
  providerName: ProQuest
– databaseName: SpringerLINK Contemporary 1997-Present
  dbid: RSV
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Ni9YwEB50VdiL3x_VVSp402LbJE1y8KDi4kEW8WPZW0jSRBel7_K2K3jzN_mT_CXOpB_y6rqgl0KbaZlOMjPPkMkMwIPIoogc9dtpLgvqaFw4j8YwOutj5X2jUgHT_Vdyb08dHOjX06Gwfs52n7ckk6VOaq2axz1aW6ELCnfSAc5CnIVz6O4UqeObt_vL3oFGpzMfjznxvQ0XlCr1nwQv_8yS_G2rNHmg3Uv_x_tluDghzvzpuESuwJnQXYULYw_Kr9fgCct_fPteCLrmiWGE45_ylMJOvbBCnw-rfCCXNhsY_BpORU8J09fh_e6Ld89fFlNPhcLLUg2FwwDKRSVtKKN2ZeNkqINoFYuIlCziFcfxvvYyqCqWNqiyjqLV1tvaMobg6gZsdasu3IK8Ckx7xBcODRWX0mvXtpEHzqTTyjOeQTWL2fip4Dj1vfhsUuChGjOKxaBYTBKLERk8XN45GsttnEr9jGZvoaRS2enBav3BTJpnNIbhAbmqnUrF42xrHbPUWZ35Rpc6g5157s2kv73BoJSAECvLDO4vw6h5tJ1iu7A6JhoMNgUCHnkKjaCDwVzqKoOb43JauGVMcMLfGciNhbbxO5sj3eHHVAFcqoaweAaP5uX2i_W_i-v2v5Hfge2aEngoRZ3vwNawPg534bz_Mhz263tJ534Cgf8nxA
  priority: 102
  providerName: Springer Nature
Title 3 ′-5 ′ crosstalk contributes to transcriptional bursting
URI https://link.springer.com/article/10.1186/s13059-020-02227-5
https://www.ncbi.nlm.nih.gov/pubmed/33541397
https://www.proquest.com/docview/2491293300
https://www.proquest.com/docview/2487158187
https://www.proquest.com/docview/2551974791
https://pubmed.ncbi.nlm.nih.gov/PMC7860045
https://doaj.org/article/9713ee432b844654adab3a45263c6909
Volume 22
WOSCitedRecordID wos000614923400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: BioMed Central Open Access Free
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0017866
  issn: 1474-760X
  databaseCode: RBZ
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: DOA
  dateStart: 20000101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: M7P
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: 7X7
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: BENPR
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: PIMPY
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1474-760X
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0019426
  issn: 1474-760X
  databaseCode: RSV
  dateStart: 20000201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5BAakXxLuBsgoSN4iaxE5sHziwqBVIsIoKVAuXyHZsUYGyqEmRuPGb-En8EmacZGF5lAsXS34kcT6P7W_k8QzAfc984TnOb6O4SCiicWIsLobeaOsza0sZHJgePReLhVwuVfVTqC-yCRvcAw_A7SnUopzjLDcy-P7SjTZMU2BsZlGzC1f3kPVMytR4fqBw45muyMhyr8OVulAJqUrh8mdSbGxDwVv_nyjm75aSvxyXhl3o4ApcHulj_Hjo9lU459prcGkIKPn5Ojxi8bcvX5OC0jh8Gbn1-zjYo1NgK9fF_SruaX-aVgt8G-LakfXzDXh9sP_qydNkDJCQWJHKPjGoDRkvhXapVyYtjXC5KxrJPNIejeTDcMznVjiZ-VQ7mea-aJS2OteMIVO6CVvtqnU7EGeOKYtkweCqw4WwyjSN54i7MEpaxiPIJrxqO3oPpyAWH-qgRciyHjCuEeM6YFwXETxYP_Nx8J1xZus5DcO6Jfm9DgUoDfUoDfW_pCGC3WkQ63EydjVqmMRqWJpGcG9djdOIzkZ061an1AY1xwLZizijTUG3fLlQWQS3BrlY95axghOZjkBsSMzG72zWtMfvgjtvIUsi1hE8nGTrR9f_Dtft_wHXHdjOyUaHrND5Lmz1J6fuLly0n_rj7mQG58VShFTO4MJ8f1EdzsI0m5GFbIVl1bMX1RvMHc7fUvry6Dv38irf
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL70egQJDgBFGTOIntQ4V4Va26rHooqDfXduy2Au2WzRbUG7-IAz-JX8KMk2y1PPbWA5dISbyR43zzzcx6HgBPPPOlL1C-jSx4Qh2NE2ORDL3R1mfWViIUMP0w4MOh2N2V20vwvc-FobDKnhMDUddjS_-Rr6KbQKqJpemLo88JdY2i3dW-hUYLiy138hVdtmZt8w1-36d5vv525_VG0nUVSCxPxTQx6EIYL7h2qZcmrQx3uStrwTzaCho1tinwPLfcicyn2ok092UttdW5ZgzNC3zuOTiPZkQuQqjg9mzXgguyjboTWeRtahMFPJay6jN2RLXaoOIoZUKeW8hFTco5rRiaB_zN4v0zcPO33dugFNev_m_LeQ2udOZ3_LKVl-uw5EY34GLbkPPkJqyx-Oe3H0lJxzgsFfomH-MQz0-NwVwTT8fxlPR7z7b4NMRlQ9Hjt-D9mcz9NiyPxiN3F-LMMWnR2DLI2gXnVpq69oUrGDdSWFZEkPUfWNmu-jo1AfmkghcmKtWCQiEoVACFKiN4NvvNUVt7ZOHoV4Sb2UiqGx4ujCf7qqMhJXnGHM4qNyJU0tO1NkxTm3lmK5nKCFZ6uKiOzBp1ipUIHs9uIw3R3pIeufExjUHPu0Trjy8YU1KWdMFlFsGdFsiz2TJWFuSMRMDnID73OvN3RocHoRw6Sh05JhE874XhdOr_Xq57i9_0EVza2Hk3UIPN4dZ9uJxTJBPF6hcrsDydHLsHcMF-mR42k4eBAmLYO2sh-QXSbJP_
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BeYgLzwKBAkHiBlGzsRPbBw68ViCqVSWg6s2yHRsqULbapEjc-E38JH4JM84DFkolxCVS4nFkj2fsb-R5ADwILJSBo35bxUVGFY0z63AzDNa4MHOukjGB6d6OWCzk_r7a_SWKP3q7j1eSfUwDZWlquu3DOvQqLqvtFnfeUmVk-sRgzqw8DWc4FQ0ie_3N3nSPoPAAGkNlju23dhzFrP3HQc0_PSZ_uzaNp9H80v_P4zJcHJBo-qQXnStwyjdX4Vxfm_LLNXjM0u9fv2UlPdM4eITpH9Po2k41snybdsu0o6Nu3Hjwb7hELTlSb8K7-Yu3z15mQ62FzIlcdplFw8oGKYzPg7J5ZYUvfFlLFhBBGcQxluN74YSXs5AbL_MilLUyzhSGMQRd12GjWTb-JqQzz5RD3GFxA-NCOGXrOnDPmbBKOsYTmI0s125IRE71MD7paJDISvds0cgWHdmiywQeTn0O-zQcJ1I_pZWcKCmFdvywXL3Xg0Zqhea5x1EVVsakcqY2lhmquM5cpXKVwNYoB3rQ61ajsUoAieV5AvenZtRIumYxjV8eEQ0aoSUCIXECTUkBw1yoWQI3etGaRstYyQmXJyDWhG5tOustzcGHmBlcyIowegKPRtH7OfS_s-vWv5Hfg_O7z-d659Xi9W24UJCPD3mx8y3Y6FZH_g6cdZ-7g3Z1N6riD2BvM4w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=3+%27-5+%27+crosstalk+contributes+to+transcriptional+bursting&rft.jtitle=Genome+biology&rft.au=Cavallaro%2C+Massimo&rft.au=Walsh%2C+Mark+D&rft.au=Jones%2C+Matt&rft.au=Teahan%2C+James&rft.date=2021-02-04&rft.issn=1474-760X&rft.eissn=1474-760X&rft.volume=22&rft.issue=1&rft.spage=56&rft_id=info:doi/10.1186%2Fs13059-020-02227-5&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1474-760X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1474-760X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1474-760X&client=summon