Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies

Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction i...

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Vydáno v:	Biological psychiatry (1969) Ročník 67; číslo 5; s. 465 - 470
Hlavní autoři:	Maciag, Dorota, Hughes, Jonathan, O'Dwyer, Gillian, Pride, Yilianys, Stockmeier, Craig A., Sanacora, Gerard, Rajkowska, Grazyna
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York, NY Elsevier Inc 01.03.2010 Elsevier
Témata:	Adolescent Adult Adult and adolescent clinical studies Aged Biological and medical sciences Calbindin immunoreactivity Calbindins Depression Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Female GABAergic neurons Humans Immunohistochemistry Interneurons - immunology Interneurons - metabolism major depression Male Medical sciences Middle Aged Mood disorders occipital cortex Occipital Lobe - metabolism Occipital Lobe - physiopathology postmortem Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, GABA - immunology Receptors, GABA - metabolism S100 Calcium Binding Protein G - immunology S100 Calcium Binding Protein G - metabolism Young Adult GABAergic neurons occipital cortex Calbindin immunoreactivity postmortem major depression Mood disorder Calbindin Calcium Central nervous system Postmortem Depression Inorganic element Density Encephalon Binding protein Occipital cortex Gabaergic neuron
ISSN:	0006-3223, 1873-2402, 1873-2402
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Shrnutí:	Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease. A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects. The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects. The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0006-3223 1873-2402 1873-2402
DOI:	10.1016/j.biopsych.2009.10.027