Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies

Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction i...

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Bibliographic Details
Published in:	Biological psychiatry (1969) Vol. 67; no. 5; pp. 465 - 470
Main Authors:	Maciag, Dorota, Hughes, Jonathan, O'Dwyer, Gillian, Pride, Yilianys, Stockmeier, Craig A., Sanacora, Gerard, Rajkowska, Grazyna
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01.03.2010 Elsevier
Subjects:	Adolescent Adult Adult and adolescent clinical studies Aged Biological and medical sciences Calbindin immunoreactivity Calbindins Depression Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Female GABAergic neurons Humans Immunohistochemistry Interneurons - immunology Interneurons - metabolism major depression Male Medical sciences Middle Aged Mood disorders occipital cortex Occipital Lobe - metabolism Occipital Lobe - physiopathology postmortem Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, GABA - immunology Receptors, GABA - metabolism S100 Calcium Binding Protein G - immunology S100 Calcium Binding Protein G - metabolism Young Adult GABAergic neurons occipital cortex Calbindin immunoreactivity postmortem major depression Mood disorder Calbindin Calcium Central nervous system Postmortem Depression Inorganic element Density Encephalon Binding protein Occipital cortex Gabaergic neuron
ISSN:	0006-3223, 1873-2402, 1873-2402
Online Access:	Get full text
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