Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies
Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction i...
Uloženo v:
| Vydáno v: | Biological psychiatry (1969) Ročník 67; číslo 5; s. 465 - 470 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
New York, NY
Elsevier Inc
01.03.2010
Elsevier |
| Témata: | |
| ISSN: | 0006-3223, 1873-2402, 1873-2402 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease.
A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects.
The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects.
The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. |
|---|---|
| AbstractList | Several lines of evidence suggest dysfunction of the g-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease. Methods - A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects. Results - The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects. Conclusions - The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease. A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects. The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects. The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. Several lines of evidence suggest dysfunction of the gamma-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease.BACKGROUNDSeveral lines of evidence suggest dysfunction of the gamma-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease.A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects.METHODSA three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects.The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects.RESULTSThe density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects.The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients.CONCLUSIONSThe reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. Several lines of evidence suggest dysfunction of the gamma-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease. A three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects. The density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects. The reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. BackgroundSeveral lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced levels of GABA in the dorsolateral prefrontal and occipital cortex of depressed patients. Our previous postmortem study revealed a reduction in the density and size of calbindin-immunoreactive (CB-IR) GABAergic neurons in the prefrontal cortex in major depressive disorder. The goal of this study was to test whether the changes in CB-IR neurons can also be detected in the occipital cortex, where neuroimaging studies report a prominent GABA decrease. MethodsA three-dimensional cell counting probe was used to assess the cell-packing density and size of CB-IR neurons in layer II of the occipital cortex in 10 major depressive disorder subjects and 10 psychiatrically healthy control subjects. ResultsThe density of CB-IR neurons was significantly decreased by 28% in major depressive disorder subjects compared with the control group. The size of CB-IR neurons was unchanged in major depressive disorder subjects when compared with control subjects. ConclusionsThe reduction in the density of CB-IR GABAergic neurons in the occipital cortex in depression is similar to that observed previously in the prefrontal cortex. Deficit in cortical GABAergic interneurons may contribute to the low GABA levels detected in neuroimaging studies in major depressive disorder patients. |
| Author | Pride, Yilianys Maciag, Dorota Stockmeier, Craig A. Hughes, Jonathan O'Dwyer, Gillian Sanacora, Gerard Rajkowska, Grazyna |
| AuthorAffiliation | 2 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 1 Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA 3 Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA |
| AuthorAffiliation_xml | – name: 3 Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA – name: 2 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA – name: 1 Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA |
| Author_xml | – sequence: 1 givenname: Dorota surname: Maciag fullname: Maciag, Dorota email: dmaciag@psychiatry.umsmed.edu organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi – sequence: 2 givenname: Jonathan surname: Hughes fullname: Hughes, Jonathan organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi – sequence: 3 givenname: Gillian surname: O'Dwyer fullname: O'Dwyer, Gillian organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi – sequence: 4 givenname: Yilianys surname: Pride fullname: Pride, Yilianys organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi – sequence: 5 givenname: Craig A. surname: Stockmeier fullname: Stockmeier, Craig A. organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi – sequence: 6 givenname: Gerard surname: Sanacora fullname: Sanacora, Gerard organization: Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut – sequence: 7 givenname: Grazyna surname: Rajkowska fullname: Rajkowska, Grazyna organization: Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22486818$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20004363$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUttuEzEUtFARTQO_UPkF8ZRwbO8VoaohQKlUqNTCs-X1niQOGzvYuxH5Bz4ar5Jw6QPhZVd7PDNnvDNn5MQ6i4ScMxgzYNnL5bgybh22ejHmAGUcjoHnj8iAFbkY8QT4CRkAQDYSnItTchbCMn7mnLMn5DRSIBGZGJAfd1h3Gmv6Fm0w7Za6GZ2qpjK2NpZer1addR6Vbs0G6dXkzQT93Gj6CTvvbKAR0y6Q3mpt1qZVDZ063-L3fv5RLZ2PsmuPIRhnX9E7bHCjrEbaup2CWam5sXN633a1wfCUPJ6pJuCz_XtIvrx_93n6YXRze3U9ndyMdA5FO0qqpISMAdZQ1IoLxaGCgmXAyqQQAmrkpag5iirNslSXScqQYR6nCrBKEzEkFzvddVetsNZoW68aufbRj99Kp4z8-8SahZy7jeQFF0XcMSQv9gLefeswtHJlgsamURZdF2SepKVgEB9HkUKkCc8SiMjzP039cnPIKgKe7wEqaNXMfPyVJvzG8aTICtabe73Dae9C8DiTOkbTxgjiXUwjGci-QnIpDxXqd5T9PFYo0rMH9MOGo8TLHRFjdBuDXgZtMMZdG4-6lbUzxyUuHkjoxlgTb_sVtxiWrvM2FkMyGbgEed8XvO83lMB4XqT_FvgfBz8BNCYQAw |
| CODEN | BIPCBF |
| CitedBy_id | crossref_primary_10_1002_hipo_22382 crossref_primary_10_1016_j_neuroscience_2023_10_021 crossref_primary_10_1016_j_jad_2017_04_053 crossref_primary_10_1016_j_neuron_2019_03_013 crossref_primary_10_1134_S1819712415010043 crossref_primary_10_1016_j_cobeha_2016_09_012 crossref_primary_10_1016_j_nicl_2019_101725 crossref_primary_10_1038_s41398_025_03371_x crossref_primary_10_1016_j_ceb_2011_09_002 crossref_primary_10_3390_cells11030390 crossref_primary_10_1007_s12149_016_1119_2 crossref_primary_10_1111_j_1476_5381_2010_01004_x crossref_primary_10_3389_fnins_2023_1187758 crossref_primary_10_1016_j_nbd_2014_10_005 crossref_primary_10_1016_j_neubiorev_2014_07_016 crossref_primary_10_1186_1756_6606_7_38 crossref_primary_10_1016_j_neurobiolaging_2017_06_023 crossref_primary_10_1503_jpn_180230 crossref_primary_10_1038_s41380_022_01540_8 crossref_primary_10_1186_s12888_023_04519_z crossref_primary_10_1016_j_yfrne_2014_06_001 crossref_primary_10_1515_revneuro_2020_0134 crossref_primary_10_1016_j_ijchp_2025_100593 crossref_primary_10_1038_s41598_021_83739_3 crossref_primary_10_1177_2470547017720459 crossref_primary_10_1016_j_pnpbp_2020_110049 crossref_primary_10_1016_j_biopsych_2010_01_003 crossref_primary_10_1016_j_jchemneu_2015_10_008 crossref_primary_10_1016_j_neuroscience_2019_01_021 crossref_primary_10_1016_j_pnpbp_2024_111149 crossref_primary_10_1515_revneuro_2015_0066 crossref_primary_10_3389_fncel_2017_00270 crossref_primary_10_52965_001c_38956 crossref_primary_10_1016_j_pnpbp_2013_04_009 crossref_primary_10_1016_j_lfs_2024_122988 crossref_primary_10_1097_MD_0000000000004918 crossref_primary_10_1074_jbc_RA119_012047 crossref_primary_10_1007_s40473_017_0108_7 crossref_primary_10_1002_nep3_70009 crossref_primary_10_20960_nh_02953 crossref_primary_10_1038_mp_2014_68 crossref_primary_10_1176_appi_ajp_2020_20071050 crossref_primary_10_1038_npp_2012_4 crossref_primary_10_1080_00207454_2020_1829618 crossref_primary_10_3389_fncel_2018_00148 crossref_primary_10_1111_j_1399_5618_2010_00874_x crossref_primary_10_1007_s00429_023_02705_z crossref_primary_10_1371_journal_pone_0075058 crossref_primary_10_1002_glia_23994 crossref_primary_10_1016_j_neulet_2012_05_058 crossref_primary_10_1016_j_neuropharm_2012_06_066 crossref_primary_10_3389_fncel_2016_00086 crossref_primary_10_1016_j_ibneur_2021_06_002 crossref_primary_10_1038_mp_2015_65 crossref_primary_10_1016_j_bbr_2020_112516 crossref_primary_10_1097_WCO_0b013e3283499d51 crossref_primary_10_1038_tp_2016_212 crossref_primary_10_3389_fpsyt_2021_665347 crossref_primary_10_1038_mp_2011_23 crossref_primary_10_3389_fpsyt_2021_678384 crossref_primary_10_1016_j_nbd_2011_01_014 crossref_primary_10_2174_1381612826666200406090051 crossref_primary_10_1016_j_npep_2023_102322 crossref_primary_10_3389_fncel_2019_00087 crossref_primary_10_1016_j_isci_2022_104201 crossref_primary_10_1016_j_bbr_2019_112224 crossref_primary_10_1016_j_neubiorev_2010_10_002 crossref_primary_10_1007_s12264_023_01052_7 crossref_primary_10_1002_hbm_23165 crossref_primary_10_1093_ijnp_pyv122 crossref_primary_10_1016_j_jad_2020_05_109 crossref_primary_10_1016_j_jad_2023_10_157 crossref_primary_10_1016_j_neuropharm_2012_08_001 crossref_primary_10_1111_febs_12407 crossref_primary_10_1134_S1819712415010134 crossref_primary_10_1016_j_bbi_2025_05_023 crossref_primary_10_1111_jcmm_14596 crossref_primary_10_1016_j_neuroscience_2018_11_008 crossref_primary_10_1016_S1734_1140_13_71518_4 crossref_primary_10_1080_09540261_2017_1283297 crossref_primary_10_1016_j_neubiorev_2010_12_007 crossref_primary_10_1177_0300060514533524 crossref_primary_10_1016_j_jad_2023_09_024 crossref_primary_10_1016_j_jpsychires_2018_04_020 crossref_primary_10_1177_2398212818799269 crossref_primary_10_3389_fncel_2018_00323 crossref_primary_10_1007_s12264_018_0235_5 crossref_primary_10_1038_tp_2016_181 crossref_primary_10_1038_mp_2016_188 crossref_primary_10_2147_DDDT_S532905 crossref_primary_10_1016_j_neubiorev_2017_09_014 crossref_primary_10_1038_mp_2015_83 crossref_primary_10_1016_j_neuroscience_2020_11_001 crossref_primary_10_1016_j_neuroscience_2012_09_057 crossref_primary_10_1016_j_neuroscience_2011_09_052 crossref_primary_10_1503_jpn_200091 crossref_primary_10_1177_2633105520979841 crossref_primary_10_12688_f1000research_18758_1 crossref_primary_10_3390_ijms22147339 crossref_primary_10_1016_j_pharmthera_2019_02_017 crossref_primary_10_1155_da_5180077 crossref_primary_10_1002_hipo_23285 crossref_primary_10_1186_s13293_019_0226_x crossref_primary_10_1016_j_neuropharm_2014_07_019 crossref_primary_10_1038_s41380_023_02193_x crossref_primary_10_1124_pr_116_013227 crossref_primary_10_1038_tp_2016_209 crossref_primary_10_3389_fpsyt_2023_1073984 crossref_primary_10_1503_jpn_150223 crossref_primary_10_3389_fgene_2020_00832 crossref_primary_10_1016_j_biopsych_2017_05_024 crossref_primary_10_1155_2017_8305287 crossref_primary_10_1017_S1461145710001616 |
| Cites_doi | 10.1016/S0193-953X(05)70271-9 10.1111/j.1600-0447.1996.tb09869.x 10.1001/archpsyc.61.7.705 10.1016/j.biopsych.2008.10.025 10.1016/j.jad.2008.04.021 10.1016/j.schres.2004.02.017 10.1016/j.jad.2006.06.016 10.1523/JNEUROSCI.5369-06.2007 10.1073/pnas.0808699105 10.1016/j.biopsych.2006.10.006 10.1001/archpsyc.56.11.1043 10.1016/0165-0327(95)00025-I 10.1016/j.biopsych.2006.08.048 10.1016/S0006-3223(99)00041-4 10.1016/S0165-0270(99)00114-4 10.1016/j.biopsych.2005.06.009 10.1523/JNEUROSCI.1003-09.2009 10.1016/0006-3223(92)90226-P 10.1016/S0165-0327(99)00194-9 10.1016/j.biopsych.2004.10.016 10.2174/187152707780363294 10.1001/archpsyc.64.2.193 10.1038/sj.npp.1301234 |
| ContentType | Journal Article |
| Copyright | 2010 Society of Biological Psychiatry Society of Biological Psychiatry 2015 INIST-CNRS Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2010 Society of Biological Psychiatry – notice: Society of Biological Psychiatry – notice: 2015 INIST-CNRS – notice: Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. – notice: Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7QO 7TK 8FD FR3 P64 5PM |
| DOI | 10.1016/j.biopsych.2009.10.027 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Biotechnology Research Abstracts Neurosciences Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Engineering Research Database Biotechnology Research Abstracts Technology Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts |
| DatabaseTitleList | Engineering Research Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Biology |
| EISSN | 1873-2402 |
| EndPage | 470 |
| ExternalDocumentID | PMC2823848 20004363 22486818 10_1016_j_biopsych_2009_10_027 S0006322309012785 1_s2_0_S0006322309012785 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIMH NIH HHS grantid: K02 MH076222 – fundername: NIMH NIH HHS grantid: R01 MH067996 – fundername: NIMH NIH HHS grantid: MH60451 – fundername: NIMH NIH HHS grantid: MH67996 – fundername: NCRR NIH HHS grantid: RR17701 – fundername: NIMH NIH HHS grantid: R01 MH071676 – fundername: NIMH NIH HHS grantid: P50 MH060451 – fundername: NCRR NIH HHS grantid: P20 RR017701 – fundername: NIMH NIH HHS grantid: MH076222 |
| GroupedDBID | --- --K --M -DZ .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABCQX ABDPE ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABMZM ABUFD ABWVN ABXDB ACDAQ ACGFO ACIEU ACIUM ACLOT ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HMK HMO HMQ HVGLF HZ~ H~9 IHE J1W KOM L7B M29 M2V M39 M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SNS SPCBC SSH SSN SSZ T5K UAP UNMZH UPT UV1 WH7 WUQ XJT XOL Z5R ZCA ZGI ZKB ZXP ~G- ~HD AACTN AFCTW AFKWA AJOXV AMFUW PKN RIG AADPK AAIAV ABLVK ABYKQ AJBFU G8K LCYCR ZA5 9DU AAYXX CITATION AGCQF AGRNS IQODW CGR CUY CVF ECM EIF NPM 7X8 7QO 7TK 8FD FR3 P64 5PM |
| ID | FETCH-LOGICAL-c708t-4b490610ed08da23a20b081601948330de293d2e3b5665c9451e1e7e29a0eb543 |
| ISICitedReferencesCount | 132 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000275100300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0006-3223 1873-2402 |
| IngestDate | Tue Nov 04 02:00:22 EST 2025 Tue Oct 07 09:34:38 EDT 2025 Mon Sep 29 06:19:51 EDT 2025 Mon Jul 21 06:01:18 EDT 2025 Mon Jul 21 09:13:22 EDT 2025 Sat Nov 29 07:34:42 EST 2025 Tue Nov 18 22:17:32 EST 2025 Fri Feb 23 02:26:55 EST 2024 Sun Feb 23 10:19:40 EST 2025 Tue Oct 14 19:29:38 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | GABAergic neurons occipital cortex Calbindin immunoreactivity postmortem major depression Mood disorder Calbindin Calcium Central nervous system Postmortem Depression Inorganic element Density Encephalon Binding protein Occipital cortex Gabaergic neuron |
| Language | English |
| License | CC BY 4.0 Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c708t-4b490610ed08da23a20b081601948330de293d2e3b5665c9451e1e7e29a0eb543 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/2823848 |
| PMID | 20004363 |
| PQID | 733542640 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2823848 proquest_miscellaneous_745931059 proquest_miscellaneous_733542640 pubmed_primary_20004363 pascalfrancis_primary_22486818 crossref_citationtrail_10_1016_j_biopsych_2009_10_027 crossref_primary_10_1016_j_biopsych_2009_10_027 elsevier_sciencedirect_doi_10_1016_j_biopsych_2009_10_027 elsevier_clinicalkeyesjournals_1_s2_0_S0006322309012785 elsevier_clinicalkey_doi_10_1016_j_biopsych_2009_10_027 |
| PublicationCentury | 2000 |
| PublicationDate | 2010-03-01 |
| PublicationDateYYYYMMDD | 2010-03-01 |
| PublicationDate_xml | – month: 03 year: 2010 text: 2010-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States |
| PublicationTitle | Biological psychiatry (1969) |
| PublicationTitleAlternate | Biol Psychiatry |
| PublicationYear | 2010 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Mason, Petrakis, de Graaf, Gueorguieva, Guidone, Coric (bib19) 2006; 59 Hasler, Fromm, Alvarez, Luckenbaugh, Drevets, Grillon (bib28) 2007; 27 McGirr, Renaud, Seguin, Alda, Benkelfat, Lesage, Turecki (bib17) 2007; 97 Bubl, Van Elst, Gondan, Ebert, Greenlee (bib26) 2007; 12 Rajkowska, O'Dwyer, Teleki, Stockmeier, Miguel-Hidalgo (bib8) 2007; 32 First, Donovan, Frances (bib14) 1996; 19 Normann, Schmitz, Fürmaier, Döing, Bach (bib25) 2007; 62 Gos, Günther, Bielau, Dobrowolny, Mawrin, Trübner (bib10) 2009; 113 Sanacora, Saricicek (bib1) 2007; 6 Karolewicz, Maciag, O'Dwyer, Stockmeier, Rajkowska (bib9) 2009 Golomb, McDavitt, Ruf, Chen, Saricicek, Maloney (bib27) 2009; 29 Bhagwagar, Wylezinska, Jezzard, Evans, Ashworth, Sule, Cohen (bib5) 2007; 61 Sanacora, Gueorguieva, Epperson, Wu, Appel, Rothman, Krystal (bib3) 2004; 61 Fatemi, Stary, Earle, Araghi-Niknam, Eagan (bib11) 2005; 72 Price, Shungu, Mao, Nestadt, Kelly, Collins (bib6) 2009; 65 Friberg, Borrero (bib22) 2000; 61 Coullaut-Valera García, Arbaiza Díaz del Rio, Coullaut-Valera García, Ortiz (bib24) 2007; 35 Kelly, Mann (bib16) 1996; 94 Hasler, van der Veen, Tumonis, Meyers, Shen, Drevets (bib4) 2007; 64 Rajkowska, Miguel-Hidalgo, Wei, Dilley, Pittman, Meltzer (bib12) 1999; 45 Spitzer, Endicott (bib13) 1978 Petty (bib7) 1995; 34 Miguel-Hidalgo, Rajkowska (bib18) 1999; 93 Satta, Maloku, Zhubi, Pibiri, Hajos, Costa, Guidotti (bib20) 2008; 105 Deep-Soboslay, Akil, Martin, Bigelow, Herman, Hyde, Kleinman (bib15) 2005; 57 Benes, Berretta (bib21) 2001; 50 Vasile, Duffy, McAnulty, Mooney, Bloomingdale, Schildkraut (bib23) 1992; 31 Sanacora, Mason, Rothman, Behar, Hyder, Petroff (bib2) 1999; 56 Karolewicz (10.1016/j.biopsych.2009.10.027_bib9) 2009 McGirr (10.1016/j.biopsych.2009.10.027_bib17) 2007; 97 Benes (10.1016/j.biopsych.2009.10.027_bib21) 2001; 50 Petty (10.1016/j.biopsych.2009.10.027_bib7) 1995; 34 Mason (10.1016/j.biopsych.2009.10.027_bib19) 2006; 59 Gos (10.1016/j.biopsych.2009.10.027_bib10) 2009; 113 Vasile (10.1016/j.biopsych.2009.10.027_bib23) 1992; 31 Price (10.1016/j.biopsych.2009.10.027_bib6) 2009; 65 First (10.1016/j.biopsych.2009.10.027_bib14) 1996; 19 Friberg (10.1016/j.biopsych.2009.10.027_bib22) 2000; 61 Coullaut-Valera García (10.1016/j.biopsych.2009.10.027_bib24) 2007; 35 Miguel-Hidalgo (10.1016/j.biopsych.2009.10.027_bib18) 1999; 93 Normann (10.1016/j.biopsych.2009.10.027_bib25) 2007; 62 Sanacora (10.1016/j.biopsych.2009.10.027_bib1) 2007; 6 Fatemi (10.1016/j.biopsych.2009.10.027_bib11) 2005; 72 Sanacora (10.1016/j.biopsych.2009.10.027_bib2) 1999; 56 Rajkowska (10.1016/j.biopsych.2009.10.027_bib8) 2007; 32 Kelly (10.1016/j.biopsych.2009.10.027_bib16) 1996; 94 Bhagwagar (10.1016/j.biopsych.2009.10.027_bib5) 2007; 61 Satta (10.1016/j.biopsych.2009.10.027_bib20) 2008; 105 Golomb (10.1016/j.biopsych.2009.10.027_bib27) 2009; 29 Bubl (10.1016/j.biopsych.2009.10.027_bib26) 2007; 12 Hasler (10.1016/j.biopsych.2009.10.027_bib28) 2007; 27 Sanacora (10.1016/j.biopsych.2009.10.027_bib3) 2004; 61 Hasler (10.1016/j.biopsych.2009.10.027_bib4) 2007; 64 Spitzer (10.1016/j.biopsych.2009.10.027_bib13) 1978 Deep-Soboslay (10.1016/j.biopsych.2009.10.027_bib15) 2005; 57 Rajkowska (10.1016/j.biopsych.2009.10.027_bib12) 1999; 45 |
| References_xml | – volume: 34 start-page: 275 year: 1995 end-page: 281 ident: bib7 article-title: GABA and mood disorders: A brief review and hypothesis publication-title: J Affect Disord – volume: 113 start-page: 45 year: 2009 end-page: 55 ident: bib10 article-title: Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-immunorective neuropil publication-title: J Affect Disord – volume: 6 start-page: 127 year: 2007 end-page: 140 ident: bib1 article-title: GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action publication-title: CNS Neurol Disord Drug Targets – volume: 105 start-page: 16356 year: 2008 end-page: 16361 ident: bib20 article-title: Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons publication-title: Proc Natl Acad Sci U S A – volume: 97 start-page: 203 year: 2007 end-page: 209 ident: bib17 article-title: An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: A psychological autopsy study publication-title: J Affect Disord – volume: 29 start-page: 9072 year: 2009 end-page: 9077 ident: bib27 article-title: Enhanced visual motion perception in major depressive disorder publication-title: J Neurosci – year: 1978 ident: bib13 article-title: Schedule for Affective Disorders and Schizophrenia (SADS) – volume: 50 start-page: 395 year: 2001 end-page: 406 ident: bib21 article-title: GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder publication-title: Neuropsychopharmacology – volume: 64 start-page: 193 year: 2007 end-page: 200 ident: bib4 article-title: Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy publication-title: Arch Gen Psychiatry – volume: 59 start-page: 85 year: 2006 end-page: 93 ident: bib19 article-title: Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: Preliminary evidence of modification by cigarette smoking publication-title: Biol Psychiatry – volume: 93 start-page: 69 year: 1999 end-page: 79 ident: bib18 article-title: Immunohistochemistry of neural markers for the study of the laminar cytoarchitecture in celloidin sections from the human cerebral cortex publication-title: J Neurosci Methods – volume: 72 start-page: 109 year: 2005 end-page: 122 ident: bib11 article-title: GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum publication-title: Schizophr Res – volume: 94 start-page: 337 year: 1996 end-page: 343 ident: bib16 article-title: Validity of DSM-III-R diagnosis by psychological autopsy: A comparison with clinician ante-mortem diagnosis publication-title: Acta Psychiatr Scand – volume: 61 start-page: 113 year: 2000 end-page: 118 ident: bib22 article-title: Diminished perception of ambient light: A symptom of clinical depression? publication-title: J Affect Disord – volume: 56 start-page: 1043 year: 1999 end-page: 1047 ident: bib2 article-title: Reduced cortical γ-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy publication-title: Arch Gen Psychiatry – volume: 62 start-page: 373 year: 2007 end-page: 380 ident: bib25 article-title: Long-term plasticity of visually evoked potentials in humans is altered in major depression publication-title: Biol Psychiatry – volume: 65 start-page: 792 year: 2009 end-page: 800 ident: bib6 article-title: Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: Relationship to treatment resistance in major depressive disorder publication-title: Biol Psychiatry – volume: 32 start-page: 471 year: 2007 end-page: 482 ident: bib8 article-title: GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression publication-title: Neuropsychopharmacology – volume: 57 start-page: 96 year: 2005 end-page: 101 ident: bib15 article-title: Reliability of psychiatric diagnosis in postmortem research publication-title: Bioll Psychiatry – volume: 45 start-page: 1085 year: 1999 end-page: 1098 ident: bib12 article-title: Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression publication-title: Biol Psychiatry – volume: 35 start-page: 243 year: 2007 end-page: 248 ident: bib24 article-title: Alterations of P300 wave in occipital lobe in depressive patients publication-title: Actas Esp Psiquiatr – volume: 27 start-page: 6313 year: 2007 end-page: 6319 ident: bib28 article-title: Cerebral blood flow in immediate and sustained anxiety publication-title: J Neurosci – year: 2009 ident: bib9 article-title: Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression publication-title: Int J Neuropsychopharmacol – volume: 19 start-page: 29 year: 1996 end-page: 39 ident: bib14 article-title: Nosology of chronic mood disorders publication-title: Psychiatr Clin North Am – volume: 31 start-page: 325 year: 1992 end-page: 336 ident: bib23 article-title: Abnormal flash visual evoked response in melancholia: A replication study publication-title: Biol Psychiatry – volume: 12 start-page: 1 year: 2007 end-page: 8 ident: bib26 article-title: Vision in depressive disorder publication-title: World J Biol Psychiatry – volume: 61 start-page: 806 year: 2007 end-page: 812 ident: bib5 article-title: Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects publication-title: Biol Psychiatry – volume: 61 start-page: 705 year: 2004 end-page: 713 ident: bib3 article-title: Subtype-specific alterations of GABA and glutamate in major depression publication-title: Arch Gen Psychiatry – volume: 12 start-page: 1 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib26 article-title: Vision in depressive disorder publication-title: World J Biol Psychiatry – volume: 19 start-page: 29 year: 1996 ident: 10.1016/j.biopsych.2009.10.027_bib14 article-title: Nosology of chronic mood disorders publication-title: Psychiatr Clin North Am doi: 10.1016/S0193-953X(05)70271-9 – volume: 94 start-page: 337 year: 1996 ident: 10.1016/j.biopsych.2009.10.027_bib16 article-title: Validity of DSM-III-R diagnosis by psychological autopsy: A comparison with clinician ante-mortem diagnosis publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.1996.tb09869.x – volume: 61 start-page: 705 year: 2004 ident: 10.1016/j.biopsych.2009.10.027_bib3 article-title: Subtype-specific alterations of GABA and glutamate in major depression publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.61.7.705 – volume: 65 start-page: 792 year: 2009 ident: 10.1016/j.biopsych.2009.10.027_bib6 article-title: Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: Relationship to treatment resistance in major depressive disorder publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2008.10.025 – volume: 113 start-page: 45 year: 2009 ident: 10.1016/j.biopsych.2009.10.027_bib10 article-title: Suicide and depression in the quantitative analysis of glutamic acid decarboxylase-immunorective neuropil publication-title: J Affect Disord doi: 10.1016/j.jad.2008.04.021 – volume: 72 start-page: 109 year: 2005 ident: 10.1016/j.biopsych.2009.10.027_bib11 article-title: GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum publication-title: Schizophr Res doi: 10.1016/j.schres.2004.02.017 – volume: 97 start-page: 203 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib17 article-title: An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: A psychological autopsy study publication-title: J Affect Disord doi: 10.1016/j.jad.2006.06.016 – volume: 27 start-page: 6313 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib28 article-title: Cerebral blood flow in immediate and sustained anxiety publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5369-06.2007 – volume: 105 start-page: 16356 year: 2008 ident: 10.1016/j.biopsych.2009.10.027_bib20 article-title: Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0808699105 – volume: 62 start-page: 373 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib25 article-title: Long-term plasticity of visually evoked potentials in humans is altered in major depression publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.10.006 – volume: 56 start-page: 1043 year: 1999 ident: 10.1016/j.biopsych.2009.10.027_bib2 article-title: Reduced cortical γ-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.56.11.1043 – volume: 35 start-page: 243 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib24 article-title: Alterations of P300 wave in occipital lobe in depressive patients publication-title: Actas Esp Psiquiatr – volume: 34 start-page: 275 year: 1995 ident: 10.1016/j.biopsych.2009.10.027_bib7 article-title: GABA and mood disorders: A brief review and hypothesis publication-title: J Affect Disord doi: 10.1016/0165-0327(95)00025-I – year: 1978 ident: 10.1016/j.biopsych.2009.10.027_bib13 – volume: 61 start-page: 806 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib5 article-title: Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2006.08.048 – year: 2009 ident: 10.1016/j.biopsych.2009.10.027_bib9 article-title: Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression publication-title: Int J Neuropsychopharmacol – volume: 45 start-page: 1085 year: 1999 ident: 10.1016/j.biopsych.2009.10.027_bib12 article-title: Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(99)00041-4 – volume: 93 start-page: 69 year: 1999 ident: 10.1016/j.biopsych.2009.10.027_bib18 article-title: Immunohistochemistry of neural markers for the study of the laminar cytoarchitecture in celloidin sections from the human cerebral cortex publication-title: J Neurosci Methods doi: 10.1016/S0165-0270(99)00114-4 – volume: 59 start-page: 85 year: 2006 ident: 10.1016/j.biopsych.2009.10.027_bib19 article-title: Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: Preliminary evidence of modification by cigarette smoking publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2005.06.009 – volume: 29 start-page: 9072 year: 2009 ident: 10.1016/j.biopsych.2009.10.027_bib27 article-title: Enhanced visual motion perception in major depressive disorder publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1003-09.2009 – volume: 31 start-page: 325 year: 1992 ident: 10.1016/j.biopsych.2009.10.027_bib23 article-title: Abnormal flash visual evoked response in melancholia: A replication study publication-title: Biol Psychiatry doi: 10.1016/0006-3223(92)90226-P – volume: 50 start-page: 395 year: 2001 ident: 10.1016/j.biopsych.2009.10.027_bib21 article-title: GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder publication-title: Neuropsychopharmacology – volume: 61 start-page: 113 year: 2000 ident: 10.1016/j.biopsych.2009.10.027_bib22 article-title: Diminished perception of ambient light: A symptom of clinical depression? publication-title: J Affect Disord doi: 10.1016/S0165-0327(99)00194-9 – volume: 57 start-page: 96 year: 2005 ident: 10.1016/j.biopsych.2009.10.027_bib15 article-title: Reliability of psychiatric diagnosis in postmortem research publication-title: Bioll Psychiatry doi: 10.1016/j.biopsych.2004.10.016 – volume: 6 start-page: 127 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib1 article-title: GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action publication-title: CNS Neurol Disord Drug Targets doi: 10.2174/187152707780363294 – volume: 64 start-page: 193 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib4 article-title: Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.64.2.193 – volume: 32 start-page: 471 year: 2007 ident: 10.1016/j.biopsych.2009.10.027_bib8 article-title: GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301234 |
| SSID | ssj0007221 |
| Score | 2.3784835 |
| Snippet | Several lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced... BackgroundSeveral lines of evidence suggest dysfunction of the γ-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report... Several lines of evidence suggest dysfunction of the gamma-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report... Several lines of evidence suggest dysfunction of the g-aminobutyric acid (GABA)ergic system in major depressive disorder. Neuroimaging studies report reduced... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 465 |
| SubjectTerms | Adolescent Adult Adult and adolescent clinical studies Aged Biological and medical sciences Calbindin immunoreactivity Calbindins Depression Depressive Disorder, Major - immunology Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Female GABAergic neurons Humans Immunohistochemistry Interneurons - immunology Interneurons - metabolism major depression Male Medical sciences Middle Aged Mood disorders occipital cortex Occipital Lobe - metabolism Occipital Lobe - physiopathology postmortem Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, GABA - immunology Receptors, GABA - metabolism S100 Calcium Binding Protein G - immunology S100 Calcium Binding Protein G - metabolism Young Adult |
| Title | Reduced Density of Calbindin Immunoreactive GABAergic Neurons in the Occipital Cortex in Major Depression: Relevance to Neuroimaging Studies |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0006322309012785 https://www.clinicalkey.es/playcontent/1-s2.0-S0006322309012785 https://dx.doi.org/10.1016/j.biopsych.2009.10.027 https://www.ncbi.nlm.nih.gov/pubmed/20004363 https://www.proquest.com/docview/733542640 https://www.proquest.com/docview/745931059 https://pubmed.ncbi.nlm.nih.gov/PMC2823848 |
| Volume | 67 |
| WOSCitedRecordID | wos000275100300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-2402 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007221 issn: 0006-3223 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6jpuEEJRbuVR-4K0KpLHTOLyVMcaQOiYYUnmKcnG3VCOpkm60_4EfyU_h-BI32QYMEC9R5cRO3PPp-Bz7O-cg9Mz33IRQm4FvMk1ECTNqMRIRiyXTKIpDMk0SJotNeHt7bDLx91ut71UszOmxl2VsufTn_1XU0AbCFqGzfyBuMyg0wG8QOlxB7HC9lOA_iGSsXPCLs1oAViTOprP-rggHycFQlGquvzN6NeIFKL--TNKhSOXCFH0fx6msJwIKo1jwpWgfh7O8gGE1dTbTXDouSQTChpVjpF9U3aM6QbE6NE6Npl2TrGWmKH_o17YkxiEA5lCZ90W-CNfQOzziZX3Pv07Zef11peC3I7eQzL39IlWphT-nonnV2OgQZ_SkvtFhInAaBFGx3FqglJSS5EqJM4_IU6O6lldFPzSa3ZrKpqpWhV79qSpjcm5hUXscs-dRmst_SGU6FbxAldrgTNLuj9L2g8-yfXG2z9wNtOl4rs_aaHO0uz15Z6wFz3F0VUc1j1oU-8Vv-5kBdXMeliDAqarHcpHDdJb3WzOkDm6jW9oDwiOF3DuoxbMOuqqwseqg61tVCcIOujbWzI-76JuGNdawxvkUG1jjJqyxgTXWsMbwDMAaG1hjBWvRLmGN17B-iQ2o8SLHdVBjDep76NOb7YOtt5auJGLFns0WFo2oD4arzRObJaFDQseORMUZ8G8oI8ROOFi9icNJBN6NG_vUHfAB96A1tHnkUnIftbM84w8RpmBxR4Q7U9vmNEzEAua6TjyM4yFILx50kVuJJ4h1mn1R7eU4qPiUs6ASq6gB64t2EGsXvTD95irRzG97eJX0gyqMGhb-ACD7dz15qdVYGQyC0gns4ByMu8g3PbWJrkzvS72114ComSZ4EWwIjkMX4QqzAQBNnFyGGc9PysAjxBWum_2LR6jrE-EsdtEDhfL1-JLvMCQw7Qb-zQMixX7zTpYeyVT7DgOXhrJH_zDtx-jGWps9Qe1FccKfoivx6SItix7a8Casp5XCD-VjUX0 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Reduced+Density+of+Calbindin+Immunoreactive+GABAergic+Neurons+in+the+Occipital+Cortex+in+Major+Depression%3A+Relevance+to+Neuroimaging+Studies&rft.jtitle=Biological+psychiatry+%281969%29&rft.au=Maciag%2C+Dorota&rft.au=Hughes%2C+Jonathan&rft.au=O%27Dwyer%2C+Gillian&rft.au=Pride%2C+Yilianys&rft.date=2010-03-01&rft.pub=Elsevier+Inc&rft.issn=0006-3223&rft.eissn=1873-2402&rft.volume=67&rft.issue=5&rft.spage=465&rft.epage=470&rft_id=info:doi/10.1016%2Fj.biopsych.2009.10.027&rft.externalDocID=S0006322309012785 |
| thumbnail_m | http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00063223%2FS0006322310X00026%2Fcov150h.gif |