SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition

Background Plant genome engineering mediated by various CRISPR-based tools requires specific protospacer adjacent motifs (PAMs), such as the well-performed NGG, NG, and NNG, to initiate target recognition, which notably restricts the editable range of the plant genome. Results In this study, we thor...

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Veröffentlicht in:	Genome Biology Jg. 22; H. 1; S. 6
Hauptverfasser:	Xu, Ziyan, Kuang, Yongjie, Ren, Bin, Yan, Daqi, Yan, Fang, Spetz, Carl, Sun, Wenxian, Wang, Guirong, Zhou, Xueping, Zhou, Huanbin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 04.01.2021 Springer Nature B.V BMC
Schlagworte:	Adenosine Adenosine deaminase Animal Genetics and Genomics Base editing Bioinformatics Biomedical and Life Sciences CRISPR CRISPR-Associated Protein 9 CRISPR-Cas Systems Cytidine deaminase Deoxyribonucleic acid DNA DNA, Plant Efficiency Evolutionary Biology Gene Editing Gene loci Genes, Plant - genetics Genetic engineering genetically modified organisms genome Genome editing Genome, Plant Genomes genomics Genotype Human Genetics Life Sciences Microbial Genetics and Genomics Mutation Nuclease Oryza - genetics Plant Genetics and Genomics Plants, Genetically Modified Rice Self-targeting SpG SpRY T-DNA CRISPR SpRY Base editing Self-targeting Genome editing SpG L Oryza sativa L
ISSN:	1474-760X, 1474-7596, 1474-760X
Online-Zugang:	Volltext
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