cGAS-STING, inflammasomes and pyroptosis: an overview of crosstalk mechanism of activation and regulation

Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression and organ degeneration, but the mechanism and regulation of the crosstalk network remain unclear. Main...

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Bibliographic Details
Published in:	Cell communication and signaling Vol. 22; no. 1; pp. 22 - 21
Main Authors:	Liu, Jingwen, Zhou, Jing, Luan, Yuling, Li, Xiaoying, Meng, Xiangrui, Liao, Wenhao, Tang, Jianyuan, Wang, Zheilei
Format:	Journal Article
Language:	English
Published:	London BioMed Central 09.01.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Analysis Autoimmune diseases Bacterial infections Biomedical and Life Sciences Caspase 1 Cell Biology Cell membranes Cellular stress response cGAS-STING Chronic infection Coronaviruses Crosstalk network Cytokines Cytokines and Growth Factors Dendritic cells Development and progression Diseases Health aspects Herpes viruses Homeostasis Immune response Immunity, Innate Infection Infections Inflammasome Inflammasomes Inflammation Inflammatory diseases Innate immunity Interferon gamma Kinases Life Sciences Membrane permeability Mitochondrial DNA Mitochondrial permeability transition pore Nucleotidyltransferases Pathogens Permeability Phosphorylation Protein-Ligand Interactions Proteins Pyroptosis Radiation Receptors Regulatory proteins Review Sensors Signal transduction Vaccines Zika virus Maryland China Inflammasome Inflammation Pyroptosis Crosstalk network cGAS-STING Diseases
ISSN:	1478-811X, 1478-811X
Online Access:	Get full text
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