Recent advances in selective photothermal therapy of tumor

Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the...

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Veröffentlicht in:Journal of nanobiotechnology Jg. 19; H. 1; S. 335 - 15
Hauptverfasser: Zhao, Liping, Zhang, Xu, Wang, Xiaoxia, Guan, Xiuwen, Zhang, Weifeng, Ma, Jinlong
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 24.10.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Ablation
Animals
Biocompatibility
Biotechnology
Cancer
Cancer therapies
Care and treatment
Chemistry
Chemistry and Materials Science
Drug delivery systems
Drugs
Efficiency
Humans
Lasers
Magnetic fields
Melanoma
Metastasis
Methods
Mice
Molecular Medicine
Nanomedicine
Nanoparticles
Nanotechnology
Neoplasms - therapy
Oncology, Experimental
Phototherapy
Photothermal conversion
Photothermal Therapy
Polyethylene glycol
Review
Selective killing
Selectivity
Self-regulating
Side effects
Survival
Targeted enrichment
Tumors
Vehicles
China
Photothermal therapy
Targeted enrichment
Self-regulating
Selective killing
ISSN:1477-3155, 1477-3155
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Zusammenfassung:Photothermal therapy (PTT), which converts light energy to heat energy, has become a new research hotspot in cancer treatment. Although researchers have investigated various ways to improve the efficiency of tumor heat ablation to treat cancer, PTT may cause severe damage to normal tissue due to the systemic distribution of photothermal agents (PTAs) in the body and inaccurate laser exposure during treatment. To further improve the survival rate of cancer patients and reduce possible side effects on other parts of the body, it is still necessary to explore PTAs with high selectivity and precise treatment. In this review, we summarized strategies to improve the treatment selectivity of PTT, such as increasing the accumulation of PTAs at tumor sites and endowing PTAs with a self-regulating photothermal conversion function. The views and challenges of selective PTT were discussed, especially the prospects and challenges of their clinical applications.
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-021-01080-3