Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high con...

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Published in:	IDEAS Working Paper Series from RePEc Vol. 48; no. 6; pp. 624 - 633
Main Authors:	Okbay, Aysu, Baselmans, Bart M L, De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G, Fontana, Mark Alan, Linnér, Richard Karlsson, Gratten, Jacob, Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C, Furlotte, Nicholas A, Gonzalez, Juan R, Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W, Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J, Lind, Penelope A, Minica, Camelia C, Nolte, Ilja M, Raitakari, Olli, Rawal, Rajesh, Stergiakouli, Evie, Taylor, Kent, Wedenoja, Juho, Wellmann, Juergen, Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Cherney, Samantha, Cox, Simon R, Davis, Oliver S P, Ding, Jun, Eibich, Peter, Emeny, Rebecca T, Forstner, Andreas J, Gupta, Richa, Harris, Tamara B, Harris, Juliette M, Holliday, Elizabeth G, De Jager, Philip L, Kaakinen, Marika A, Kajantie, Eero, Kolcic, Ivana, Launer, Lenore J, Franke, Lude, Li-Gao, Ruifang, Koini, Marisa, Loukola, Anu, Montgomery, Grant W, Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E, Pulkki-Råback, Laura, Quaye, Lydia, Rudan, Igor, Scott, Rodney J, Vinkhuyzen, Anna E, Zabaneh, Delilah, Bennett, David A, Berger, Klaus, Bertram, Lars, Boomsma, Dorret I, Cucca, Francesco, Deary, Ian J, van Duijn, Cornelia M, Eriksson, Johan G, de Geus, Eco J C, Hartman, Catharine A, Hayward, Caroline, Hinds, David A, Iacono, William G, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Kubzansky, Laura D, Lehtimäki, Terho, Magnusson, Patrik K E, Pasterkamp, Gerard, Power, Christine, Rich, Stephen S, Schmidt, Helena, Svento, Rauli, Schmidt, Reinhold, Sørensen, Thorkild I A, Stefansson, Kari, Terracciano, Antonio, Tiemeier, Henning, Wagner, Gert G, Yang, Jian, Smith, George Davey, Hofman, Albert, Johannesson, Magnus, Laibson, David I, Meyer, Michelle N, Beauchamp, Jonathan P, Koellinger, Philipp D, Bartels, Meike, Cesarini, David
Format:	Journal Article Paper
Language:	English
Published:	New York Nature Publishing Group US 01.06.2016 Nature Publishing Group Federal Reserve Bank of St. Louis
Subjects:	45/43 631/208/1515 631/208/205/2138 Agriculture Animal Genetics and Genomics Anxiety Disorders - genetics Bayes Theorem Behavior Biomedicine Cancer Research Central nervous system Consortia Depression - genetics Depression, Mental Epidemiology Gene Function Genetic aspects Genetic variance Genetic variation Genome-wide association studies Genome-Wide Association Study Genomes Human Genetics Humans Identification and classification Mental depression Meta-analysis Methods Neuroticism Personality Phenotype Polymorphism, Single Nucleotide Psychological aspects Quality control Quantitative Finance Risk factors Social sciences Statistics Studies Behavioural genetics Genome-wide association studies
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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Summary:	Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sample size together with genetic correlations between the phenotypes to identify, with high confidence, loci associated with each phenotype. Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being ( n = 298,420), depressive symptoms ( n = 161,460), and neuroticism ( n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (\| ρ ^\| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Bibliography:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 SourceType-Working Papers-1 ObjectType-Working Paper/Pre-Print-1 content type line 50 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 PMCID: PMC4884152 These authors contributed equally Designed and oversaw the study.
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/ng.3552