NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice

Background Brain aging is an important risk factor in many human diseases, such as Alzheimer’s disease (AD). The production of excess reactive oxygen species (ROS) mediated by nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) and the maturation of inflammatory cytokines caused by activati...

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Bibliographic Details
Published in:	Behavioral and brain functions Vol. 17; no. 1; pp. 11 - 14
Main Authors:	Sun, Dan, Gao, Guofang, Zhong, Bihua, Zhang, Han, Ding, Shixin, Sun, Zhenghao, Zhang, Yaodong, Li, Weizu
Format:	Journal Article
Language:	English
Published:	London BioMed Central 17.12.2021 Springer Nature B.V BMC
Subjects:	Adaptor Proteins, Signal Transducing Aging Alzheimer's disease Animals Apoptosis Regulatory Proteins Behavior Behavioral Therapy Biomedical and Life Sciences Biomedicine Biotechnology Brain Brain aging Caspase-1 CYBB protein Cytokines Enzymes IL-1β Inflammasomes Inflammation Laboratory animals Learning Learning and memory impairments Locomotor activity Medical research Memory Memory Disorders Mice NAD(P)H oxidase NADPH oxidase 2 NADPH-diaphorase Neurodegenerative diseases Neuroinflammatory Diseases Neurology Neurons Neurosciences NLR Proteins NLRP1 inflammasome Psychiatry Reactive oxygen species Risk factors ROS β-Galactosidase United States > US China Germany Brain aging NLRP1 inflammasome Learning and memory impairments ROS NADPH oxidase 2
ISSN:	1744-9081, 1744-9081
Online Access:	Get full text
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