The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease

Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcript...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 294; H. 5547; S. 1731 - 1735
Hauptverfasser:	Chabas, Dorothée, Baranzini, Sergio E., Mitchell, Dennis, Claude C. A. Bernard, Rittling, Susan R., Denhardt, David T., Sobel, Raymond A., Lock, Christopher, Karpuj, Marcela, Pedotti, Rosetta, Heller, Renu, Oksenberg, Jorge R., Steinman, Lawrence
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Washington, DC American Society for the Advancement of Science 23.11.2001 American Association for the Advancement of Science The American Association for the Advancement of Science
Schlagworte:	Anatomy Animals Biological and medical sciences Brain Cytokines Demyelinating diseases Disease remission Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Expressed Sequence Tags Gene Deletion Gene Expression Profiling Gene Library Genes Genetic aspects Humans Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation - pathology Influence Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-10 - genetics Interleukin-10 - metabolism Lesions Libraries Lymphocyte Activation Medical sciences Mice Mice, Knockout Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system diseases Neurology Oligonucleotide Array Sequence Analysis Osteopontin Patients Rats Relapse RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sialoglycoproteins - deficiency Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Spinal cord Spinal Cord - metabolism T lymphocytes Th1 Cells - immunology Transcripts (Written Records) Human Nervous system diseases Multiple sclerosis Pathogenesis Central nervous system disease Cytokine Osteopontin Autoimmune disease Inflammatory disease
ISSN:	0036-8075, 1095-9203
Online-Zugang:	Volltext
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Zusammenfassung:	Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, derived from plaques dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN). Microarray analysis of spinal cords from rats paralyzed by experimental autoimmune encephalomyelitis (EAE), a model of MS, also revealed increased OPN transcripts. Osteopontin-deficient mice were resistant to progressive EAE and had frequent remissions, and myelin-reactive T cells in OPN-/-mice produced more interleukin 10 and less interferon-γ than in OPN+/+mice. Osteopontin thus appears to regulate T helper cell-1 (TH1)-mediated demyelinating disease, and it may offer a potential target in blocking development of progressive MS.
Bibliographie:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1062960