A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour ongoing demyelination and axon degeneration, and are identifiable in vivo by their paramagnetic rims on MRI scans 1 – 3 . Here, to define mechanisms underlying this disabling, progressive neurodegenerative stat...

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Bibliographic Details
Published in:	Nature (London) Vol. 597; no. 7878; pp. 709 - 714
Main Authors:	Absinta, Martina, Maric, Dragan, Gharagozloo, Marjan, Garton, Thomas, Smith, Matthew D., Jin, Jing, Fitzgerald, Kathryn C., Song, Anya, Liu, Poching, Lin, Jing-Ping, Wu, Tianxia, Johnson, Kory R., McGavern, Dorian B., Schafer, Dorothy P., Calabresi, Peter A., Reich, Daniel S.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.09.2021 Nature Publishing Group
Subjects:	13/51 45/91 59/57 631/250/2501 631/378/371 64/60 692/53/2422 692/617/375/1411/1666 Ablation Animals Antigen presentation Astrocytes Astrocytes - pathology Autoimmune diseases Biomarkers Brain - pathology Chemical compounds Complement activation Complement C1q - antagonists & inhibitors Complement C1q - metabolism Complement component C1q Degeneration Demyelination Dendritic cells Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Female Gene expression Gene sequencing Humanities and Social Sciences Humans Immune system Inflammation Inflammation - pathology Lesions Lymphocytes Lymphocytes - pathology Magnetic Resonance Imaging Male Mice Mice, Inbred C57BL Microglia Microglia - pathology Middle Aged multidisciplinary Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Neurodegeneration Neurodegenerative diseases Neuronal-glial interactions Pharmacology Phenotypes Physiological aspects Plasma Proteins RNA-Seq Science Science (multidisciplinary) Substantia alba Transcription Transcriptome Variance analysis White Matter - pathology United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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