Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and q...

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Veröffentlicht in:BMC medicine Jg. 18; H. 1; S. 261 - 14
Hauptverfasser: Soto-Angona, Óscar, Anmella, Gerard, Valdés-Florido, María José, De Uribe-Viloria, Nieves, Carvalho, Andre F., Penninx, Brenda W. J. H., Berk, Michael
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 01.10.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Anxiety
Biomedicine
Cirrhosis
Comorbidity
Complex systems
Development and progression
Environmental risk
Fatty liver
Health aspects
Humans
Life expectancy
Life span
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Medicine
Medicine & Public Health
Mental disorders
Mental Disorders - etiology
Mental Disorders - psychology
Mentally ill persons
Metabolic disorders
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - psychology
Mitochondria
Mortality
Non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - physiopathology
Non-alcoholic Fatty Liver Disease - psychology
Non-alcoholic steatohepatitis
Non-communicable disorders
Oxidative Stress
Parenchyma
Pathogenesis
Psychiatry
Quality of life
Quality of Life - psychology
Review
Steatosis
Asia
United States > US
North America
Europe
Africa
Oxidative stress
Mental disorders
Mitochondrial
Lifestyle
Inflammation
Non-alcoholic fatty liver disease
Metabolic syndrome
Non-alcoholic steatohepatitis
Non-communicable disorders
Psychiatry
ISSN:1741-7015, 1741-7015
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Zusammenfassung:Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.
Bibliographie:ObjectType-Article-1
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ISSN:1741-7015
1741-7015
DOI:10.1186/s12916-020-01713-8