Systematic functional identification of cancer multi-drug resistance genes

Background Drug resistance is a major obstacle in cancer therapy. To elucidate the genetic factors that regulate sensitivity to anti-cancer drugs, we performed CRISPR-Cas9 knockout screens for resistance to a spectrum of drugs. Results In addition to known drug targets and resistance mechanisms, thi...

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Bibliographic Details
Published in:	Genome Biology Vol. 21; no. 1; p. 27
Main Authors:	Lau, Man-Tat, Ghazanfar, Shila, Parkin, Ashleigh, Chou, Angela, Rouaen, Jourdin R., Littleboy, Jamie B., Nessem, Danielle, Khuong, Thang M., Nevoltris, Damien, Schofield, Peter, Langley, David, Christ, Daniel, Yang, Jean, Pajic, Marina, Neely, G. Gregory
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.02.2020 Springer Nature B.V BMC
Subjects:	Animal Genetics and Genomics Apoptosis Bioinformatics Biomedical and Life Sciences Biosynthesis Cancer cancer therapy Cell cycle Chemoresistance Chemotherapy CRISPR CRISPR-Cas systems Cytotoxicity death Deoxyribonucleic acid Dihydrofolate reductase DNA DNA repair Drug delivery Drug resistance Drug Resistance, Neoplasm - genetics drug therapy drugs Evolutionary Biology Gene expression genes Genetic factors Genomes Genomics HEK293 Cells HeLa Cells Human Genetics Humans Kinases Life Sciences Microbial Genetics and Genomics Multidrug resistance multiple drug resistance Plant Genetics and Genomics prognosis RNA polymerase Therapeutic targets
ISSN:	1474-760X, 1474-7596, 1474-760X
Online Access:	Get full text
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