Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements. Illumina have now released the MethylationEPIC (EPIC) BeadChip, with new conte...

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Bibliographic Details
Published in:	Genome Biology Vol. 17; no. 1; p. 208
Main Authors:	Pidsley, Ruth, Zotenko, Elena, Peters, Timothy J., Lawrence, Mitchell G., Risbridger, Gail P., Molloy, Peter, Van Djik, Susan, Muhlhausler, Beverly, Stirzaker, Clare, Clark, Susan J.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 07.10.2016 Springer Nature B.V
Subjects:	Animal Genetics and Genomics Bioinformatics Biomedical and Life Sciences Consortia CpG islands CpG Islands - genetics Deoxyribonucleic acid Design Disease DNA DNA fingerprinting DNA methylation DNA Methylation - genetics DNA microarrays DNA probes Enhancer Elements, Genetic - genetics Enhancers Epigenetics Evolutionary Biology Gene expression Genetic diversity genetic variation genome Genome, Human Genomes High-Throughput Nucleotide Sequencing Human Genetics Humans Hybridization Life Sciences loci microarray technology Microbial Genetics and Genomics Oligonucleotide Array Sequence Analysis - methods Plant Genetics and Genomics Prostate cancer Regulatory sequences Researchers Sequence Analysis, DNA - methods HM450 Validation Enhancers EPIC Whole-genome bisulphite sequencing (WGBS) DNA methylation Microarray
ISSN:	1474-760X, 1474-7596, 1474-760X
Online Access:	Get full text
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