Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as inc...

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Veröffentlicht in:	Acta neuropathologica communications Jg. 9; H. 1; S. 27 - 15
Hauptverfasser:	Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E., de Miranda, Noel F. C. C., Lelieveldt, Boudewijn P. F., Dijkstra, Jouke, van Roon-Mom, Willeke M. C., Höllt, Thomas, van der Weerd, Louise
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 17.02.2021 BioMed Central Ltd Nature Publishing Group BMC
Schlagworte:	Alzheimer Alzheimer's disease Antibodies Antigens Binding sites Biomedical and Life Sciences Biomedicine Development and progression Ferritin Histology Human Iron Microglia Neurology Neurosciences Pathology Netherlands Human Iron Alzheimer Ferritin Microglia
ISSN:	2051-5960, 2051-5960
Online-Zugang:	Volltext
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