Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as inc...

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Vydáno v:	Acta neuropathologica communications Ročník 9; číslo 1; s. 27 - 15
Hlavní autoři:	Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E., de Miranda, Noel F. C. C., Lelieveldt, Boudewijn P. F., Dijkstra, Jouke, van Roon-Mom, Willeke M. C., Höllt, Thomas, van der Weerd, Louise
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 17.02.2021 BioMed Central Ltd Nature Publishing Group BMC
Témata:	Alzheimer Alzheimer's disease Antibodies Antigens Binding sites Biomedical and Life Sciences Biomedicine Development and progression Ferritin Histology Human Iron Microglia Neurology Neurosciences Pathology Netherlands Human Iron Alzheimer Ferritin Microglia
ISSN:	2051-5960, 2051-5960
On-line přístup:	Získat plný text
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