Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Background 5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC. Recently, microRNAs (miRNAs) have been established as a means of reversing the dilemma by regulating signaling pathways invol...

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Bibliographic Details
Published in:	Journal of nanobiotechnology Vol. 18; no. 1; pp. 10 - 15
Main Authors:	Liang, Gaofeng, Zhu, Yanliang, Ali, Doulathunnisa Jaffar, Tian, Tian, Xu, Huantian, Si, Ke, Sun, Bo, Chen, Baoan, Xiao, Zhongdang
Format:	Journal Article
Language:	English
Published:	London BioMed Central 09.01.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	5-Fluorouracil 5-FU Anticancer properties Apoptosis Biological products Biotechnology Cancer cells Cancer patients Cancer therapies Care and treatment Cell cycle Chemistry Chemistry and Materials Science Chemotherapy Colon Colon cancer Colorectal cancer Colorectal carcinoma Cytotoxicity Delivery system Deoxyribonucleic acid Development and progression DNA DNA methylation Drug delivery systems Drug resistance Drug therapy Electroporation ErbB-2 protein Exosomes Fluorouracil Health aspects Inhibitors Membranes MicroRNA miR-21 inhibitor miRNA Molecular Medicine Nanotechnology Oligonucleotides Proteins PTEN protein Ribonucleic acid RNA Toxicity Tumors China Delivery system miR-21 inhibitor Exosomes Drug resistance 5-FU
ISSN:	1477-3155, 1477-3155
Online Access:	Get full text
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