Toll-like receptors in the depressed and suicide brain

Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-l...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of psychiatric research Vol. 53; pp. 62 - 68
Main Authors:	Pandey, Ghanshyam N., Rizavi, Hooriyah S., Ren, Xinguo, Bhaumik, Runa, Dwivedi, Yogesh
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01.06.2014 Elsevier
Subjects:	Adult Adult and adolescent clinical studies Aged Analysis of Variance Antidepressive Agents - therapeutic use Biological and medical sciences Cortex Cytokines Depression Depression - pathology Depression - psychology Ethanol - pharmacology Female Gene Expression - drug effects Gene Expression - physiology Humans Innate immunity Male Medical sciences Middle Aged Miscellaneous Mood disorders Postmortem brain Postmortems Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - metabolism Suicide Suicide - psychology Toll-like receptors (TLRs) Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Victims Young Adult Depression Innate immunity Toll-like receptors (TLRs) Cytokines Suicide Postmortem brain Mood disorder Central nervous system Cytokine Postmortem Encephalon Biological receptor
ISSN:	0022-3956, 1879-1379, 1879-1379
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects.
AbstractList	Abstract Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects. Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects. [Copyright Elsevier Ltd.] Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects. Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects.Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the serum and postmortem brain of depressed and suicidal patients. We have examined if abnormalities of the innate immune receptors, known as Toll-like receptors (TLRs), in the brain are associated with depression and suicide, since the activation of these receptors results in production of cytokines. Of all the TLRs shown to be present in humans, TLR3 and TLR4 appear to be unique and important in brain function. We have determined the protein (by ELISA method) and mRNA expression (using qPCR) of TLR3 and TLR4 in the postmortem brain (dorsolateral prefrontal cortex [DLPFC]) of 22 depressed suicide victims, 11 non-depressed suicide victims, 12 depressed non-suicide subjects and 20 normal control subjects. We found that the mRNA expression of TLR3 and TLR4 was significantly increased in DLPFC of depressed suicide victims and in depressed non-suicide subjects, compared with controls. However, the protein expression of TLR3 and TLR4 was significantly increased in depressed suicide victims, but not in depressed non-suicide subjects compared with controls. The observed abnormalities of proinflammatory cytokines in the brain of suicide victims may be related to an abnormality of TLR3 and TLR4 over-expression. To our knowledge, this is the first study of TLRs in the brain of psychiatric subjects.
Author	Ren, Xinguo Dwivedi, Yogesh Bhaumik, Runa Pandey, Ghanshyam N. Rizavi, Hooriyah S.
Author_xml	– sequence: 1 givenname: Ghanshyam N. surname: Pandey fullname: Pandey, Ghanshyam N. email: Gpandey@psych.uic.edu, GNPandey@psych.uic.edu – sequence: 2 givenname: Hooriyah S. surname: Rizavi fullname: Rizavi, Hooriyah S. – sequence: 3 givenname: Xinguo surname: Ren fullname: Ren, Xinguo – sequence: 4 givenname: Runa surname: Bhaumik fullname: Bhaumik, Runa – sequence: 5 givenname: Yogesh surname: Dwivedi fullname: Dwivedi, Yogesh
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28355363$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24565447$$D View this record in MEDLINE/PubMed
BookMark	eNqVkktvEzEURi1URNvAX0CzQWIz4fo1M94gaMVLqsSCsrY89h3idGIHe1Ip_x5HCQkskMLKC597dB_fNbkIMSAhFYU5Bdq8Wc6X67y1C58wzxlQMQc6B0afkCvataqmvFUX5AqAsZor2VyS65yXANAyKp6RSyZkI4Vor0hzH8exHv0DVgktrqeYcuVDNS2wcrgu_oyuMsFVeeOtd1j1yfjwnDwdzJjxxeGdke8fP9zffq7vvn76cvv-rrYt8KluOcq-b6BrGUeHg1FMtH0HvZQwcKNayp2QnMuOWinkIBQdXNuZgrjOOcln5O3eu970K3QWw5TMqNfJr0za6mi8_vsn-IX-ER-1ABC8UUXw-iBI8ecG86RXPlscRxMwbrKmUlDVKqbOQbnooFFCnIFSDpLKsoQZefnnBMfWf5-gAK8OgMnWjEMywfp84jouJW944bo9Z1PMOeFwRCjoXSr0Up9SoXep0EB1ScVpi8dS6ycz-bjbmR_PEdzsBVhu_egx6Ww9BouuoHbSLvr_6OIosaMPvsz8gFvMy7hJoWRJU52ZBv1tl95deGm5JXBgRfDu34LzevgFWaQDtw
CODEN	JPYRA3
CitedBy_id	crossref_primary_10_1111_jdv_14460 crossref_primary_10_1159_000447252 crossref_primary_10_1016_j_phymed_2023_155015 crossref_primary_10_1016_j_euroneuro_2018_11_860 crossref_primary_10_3389_fphar_2019_00501 crossref_primary_10_1038_s41380_018_0241_z crossref_primary_10_1371_journal_pone_0222818 crossref_primary_10_1016_j_jpsychores_2020_110347 crossref_primary_10_3389_fncel_2022_839396 crossref_primary_10_1016_j_psychres_2014_07_074 crossref_primary_10_1016_j_psyneuen_2015_10_008 crossref_primary_10_1038_tp_2014_129 crossref_primary_10_1016_j_bbi_2022_02_016 crossref_primary_10_1016_j_bbi_2019_06_015 crossref_primary_10_1016_j_jad_2019_11_001 crossref_primary_10_1159_000489562 crossref_primary_10_5498_wjp_v15_i7_107598 crossref_primary_10_1016_j_bbi_2019_04_004 crossref_primary_10_1016_j_bbi_2025_02_015 crossref_primary_10_1016_j_bbi_2024_12_028 crossref_primary_10_1016_j_pnpbp_2018_09_004 crossref_primary_10_1038_s41398_021_01481_w crossref_primary_10_3389_fncel_2022_923811 crossref_primary_10_1002_brb3_854 crossref_primary_10_1111_dth_12771 crossref_primary_10_1016_j_neubiorev_2024_105558 crossref_primary_10_1038_tp_2016_261 crossref_primary_10_1038_tp_2014_111 crossref_primary_10_3389_fnins_2014_00416 crossref_primary_10_1186_s12974_018_1294_2 crossref_primary_10_1016_j_neuint_2020_104891 crossref_primary_10_1016_j_bbi_2019_01_026 crossref_primary_10_1016_j_maturitas_2017_09_003 crossref_primary_10_3390_ijms25189776 crossref_primary_10_1186_s12916_019_1488_1 crossref_primary_10_1016_j_jpsychires_2016_11_011 crossref_primary_10_1016_j_pharmthera_2024_108624 crossref_primary_10_1176_appi_ajp_20250289 crossref_primary_10_1111_bph_14569 crossref_primary_10_1016_j_bbi_2017_10_025 crossref_primary_10_1016_j_mehy_2019_109404 crossref_primary_10_1186_s12916_014_0259_2 crossref_primary_10_1016_j_bbi_2021_01_033 crossref_primary_10_1007_s12035_018_1306_3 crossref_primary_10_1016_j_jpsychires_2019_05_001 crossref_primary_10_1007_s12264_016_0015_z crossref_primary_10_1007_s00406_018_0968_1 crossref_primary_10_1080_08820139_2022_2093118 crossref_primary_10_1016_j_ebiom_2023_104473 crossref_primary_10_1016_S2215_0366_18_30048_8 crossref_primary_10_1016_j_bbih_2020_100124 crossref_primary_10_1016_j_bbr_2019_112191 crossref_primary_10_3389_fpsyt_2020_00192 crossref_primary_10_1016_j_neubiorev_2016_02_013 crossref_primary_10_1016_j_bcp_2020_114140 crossref_primary_10_3390_cells14120933 crossref_primary_10_1016_j_jpsychires_2020_06_008 crossref_primary_10_1503_jpn_210016 crossref_primary_10_3389_fmicb_2022_845559 crossref_primary_10_3389_fpsyt_2024_1449526 crossref_primary_10_1016_j_jneuroim_2021_577654 crossref_primary_10_1124_pharmrev_120_000043 crossref_primary_10_1007_s00436_023_07818_2 crossref_primary_10_1016_j_phrs_2022_106625 crossref_primary_10_1016_j_pnpbp_2015_03_006 crossref_primary_10_1016_j_neuroscience_2015_04_057 crossref_primary_10_1016_j_jpsychires_2019_10_008 crossref_primary_10_1016_j_ijbiomac_2019_12_138 crossref_primary_10_1038_tp_2016_212 crossref_primary_10_1186_s42269_019_0165_z crossref_primary_10_1007_s12035_019_01687_6 crossref_primary_10_1016_j_psyneuen_2018_01_017 crossref_primary_10_1038_npp_2016_116 crossref_primary_10_1038_s41380_024_02420_z crossref_primary_10_4103_cmrp_cmrp_48_22 crossref_primary_10_1007_s12035_015_9090_9 crossref_primary_10_1016_j_neuroscience_2016_07_037 crossref_primary_10_1111_sji_12479 crossref_primary_10_1007_s12035_023_03639_7 crossref_primary_10_1111_imm_13281 crossref_primary_10_3390_genes11091089 crossref_primary_10_1016_j_pnpbp_2017_11_017 crossref_primary_10_1016_j_psychres_2023_115078 crossref_primary_10_1007_s12035_022_03199_2 crossref_primary_10_3390_ijms25126335 crossref_primary_10_1016_j_micres_2023_127440 crossref_primary_10_3389_fimmu_2024_1479471 crossref_primary_10_1016_j_pharmthera_2015_01_001 crossref_primary_10_1016_j_bbi_2016_09_017 crossref_primary_10_3109_15622975_2015_1054879 crossref_primary_10_1007_s12035_023_03737_6 crossref_primary_10_1016_j_neurot_2025_e00634 crossref_primary_10_1016_j_jpsychires_2020_12_029 crossref_primary_10_1176_appi_ajp_2017_16070759 crossref_primary_10_1007_s11920_016_0736_8 crossref_primary_10_1016_j_neulet_2020_135292 crossref_primary_10_1016_j_ejphar_2025_177884 crossref_primary_10_2174_0113816128333916241003180018 crossref_primary_10_1016_j_euroneuro_2019_11_004 crossref_primary_10_1016_j_bbi_2019_06_035 crossref_primary_10_1176_appi_focus_20220078 crossref_primary_10_1515_tnsci_2022_0236 crossref_primary_10_1016_j_neubiorev_2021_09_023 crossref_primary_10_1016_j_bbi_2018_09_024 crossref_primary_10_1016_j_psyneuen_2020_104843 crossref_primary_10_3389_fgene_2020_00826 crossref_primary_10_1155_2022_3004338 crossref_primary_10_1007_s11089_016_0725_1 crossref_primary_10_1038_npp_2016_167 crossref_primary_10_1016_j_jad_2022_12_114 crossref_primary_10_3389_fpsyt_2023_1130989 crossref_primary_10_1016_j_neuron_2020_06_002 crossref_primary_10_1016_j_schres_2017_04_043 crossref_primary_10_1128_JVI_00999_19 crossref_primary_10_1016_j_psyneuen_2019_104487
Cites_doi	10.1002/glia.20328 10.2119/2008-00034.Klune 10.1093/jnen/61.11.1013 10.1016/j.biopsych.2012.09.030 10.1038/sj.icb.7100103 10.1016/j.smim.2006.12.004 10.1016/j.brainresrev.2008.09.001 10.1038/ncb1629 10.1155/2010/672395 10.1016/j.bbi.2010.10.010 10.1146/annurev.immunol.21.120601.141126 10.1016/S0165-2478(98)00145-X 10.1002/jnr.20767 10.1083/jcb.200606016 10.1093/intimm/dxh186 10.1182/blood.V99.9.3427 10.1016/j.neurobiolaging.2007.08.018 10.1016/j.jpsychires.2006.10.013 10.4049/jimmunol.1002302 10.1007/s00018-007-6494-3 10.1038/sj.gene.6363937 10.1038/35099560 10.1177/09680519040100021001 10.1016/j.tins.2011.02.005 10.1016/j.biopsych.2009.09.033 10.1176/appi.ajp.160.7.1342 10.1016/j.coi.2005.11.012 10.1038/mp.2010.52 10.1001/archpsyc.1992.01820080032005 10.1038/sj.gene.6363791 10.1093/brain/awl249 10.1016/S0022-3565(24)39045-7 10.1016/j.neuroscience.2008.07.067 10.1016/j.pnpbp.2004.11.003 10.1042/CS20110164 10.1073/pnas.1005807107 10.1016/j.jpsychires.2011.08.006 10.1016/j.biopsych.2009.01.030 10.1385/JMN:29:3:185
ContentType	Journal Article
Copyright	2014 Elsevier Ltd Elsevier Ltd 2015 INIST-CNRS Copyright © 2014 Elsevier Ltd. All rights reserved. 2014 Elsevier Ltd. All rights reserved. 2014
Copyright_xml	– notice: 2014 Elsevier Ltd – notice: Elsevier Ltd – notice: 2015 INIST-CNRS – notice: Copyright © 2014 Elsevier Ltd. All rights reserved. – notice: 2014 Elsevier Ltd. All rights reserved. 2014
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8 7TK 7QJ 5PM
DOI	10.1016/j.jpsychires.2014.01.021
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Neurosciences Abstracts Applied Social Sciences Index & Abstracts (ASSIA) PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Neurosciences Abstracts Applied Social Sciences Index and Abstracts (ASSIA)
DatabaseTitleList	Applied Social Sciences Index and Abstracts (ASSIA) MEDLINE MEDLINE - Academic Neurosciences Abstracts
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1879-1379
EndPage	68
ExternalDocumentID	PMC4004369 24565447 28355363 10_1016_j_jpsychires_2014_01_021 S0022395614000302 1_s2_0_S0022395614000302
Genre	Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NIMH NIH HHS grantid: R01 MH048153 – fundername: NIMH NIH HHS grantid: R01 MH098554 – fundername: NIMH NIH HHS grantid: R01 MH 48153 – fundername: NIMH NIH HHS grantid: R01 MH 98554
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29L 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM 9JO AABNK AADFP AAEDT AAEDW AAGJA AAGUQ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYWO ABBQC ABCQJ ABFNM ABIVO ABJNI ABLJU ABMAC ABMZM ABOYX ABPPZ ABWVN ABXDB ACDAQ ACGFS ACHQT ACIEU ACIUM ACLOT ACNCT ACRLP ACRPL ACVFH ACXNI ADBBV ADCNI ADEZE ADMUD ADNMO ADXHL AEBSH AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEG HF~ HMK HMO HMQ HMW HVGLF HZ~ IHE J1W K-O KOM L7B M29 M2V M39 M3V M41 MO0 MOBAO N9A O-L O9- OAUVE OH0 OKEIE OU- OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SNS SPCBC SPS SSB SSH SSN SSY SSZ T5K WUQ YQT Z5R ZGI ~G- ~HD AACTN AFCTW AFKWA AJOXV AMFUW PKN RIG AADPK AAIAV ABLVK ABYKQ AFYLN AJBFU LCYCR ZA5 9DU AAYXX CITATION 08R AALMO ABFLS ABPIF ABPTK ADALY IPNFZ IQODW CGR CUY CVF ECM EIF NPM 7X8 7TK 7QJ 5PM
ID	FETCH-LOGICAL-c703t-73e5bb608723edefa9247b80b550f3a9713d4533581c545f491fd78ab80d8dd53
ISICitedReferencesCount	122
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000335104200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0022-3956 1879-1379
IngestDate	Tue Sep 30 17:03:55 EDT 2025 Sun Nov 09 11:18:40 EST 2025 Sun Sep 28 05:37:45 EDT 2025 Wed Oct 01 13:33:31 EDT 2025 Wed Feb 19 01:57:24 EST 2025 Fri Nov 25 06:04:25 EST 2022 Tue Nov 18 22:25:08 EST 2025 Sat Nov 29 07:29:18 EST 2025 Fri Feb 23 02:28:05 EST 2024 Sun Feb 23 10:18:43 EST 2025 Tue Oct 14 19:31:09 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Keywords	Depression Innate immunity Toll-like receptors (TLRs) Cytokines Suicide Postmortem brain Mood disorder Central nervous system Cytokine Postmortem Encephalon Biological receptor
Language	English
License	CC BY 4.0 Copyright © 2014 Elsevier Ltd. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c703t-73e5bb608723edefa9247b80b550f3a9713d4533581c545f491fd78ab80d8dd53
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
PMID	24565447
PQID	1513051570
PQPubID	23479
PageCount	7
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4004369 proquest_miscellaneous_1541979299 proquest_miscellaneous_1534806944 proquest_miscellaneous_1513051570 pubmed_primary_24565447 pascalfrancis_primary_28355363 crossref_primary_10_1016_j_jpsychires_2014_01_021 crossref_citationtrail_10_1016_j_jpsychires_2014_01_021 elsevier_sciencedirect_doi_10_1016_j_jpsychires_2014_01_021 elsevier_clinicalkeyesjournals_1_s2_0_S0022395614000302 elsevier_clinicalkey_doi_10_1016_j_jpsychires_2014_01_021
PublicationCentury	2000
PublicationDate	2014-06-01
PublicationDateYYYYMMDD	2014-06-01
PublicationDate_xml	– month: 06 year: 2014 text: 2014-06-01 day: 01
PublicationDecade	2010
PublicationPlace	Kidlington
PublicationPlace_xml	– name: Kidlington – name: England
PublicationTitle	Journal of psychiatric research
PublicationTitleAlternate	J Psychiatr Res
PublicationYear	2014
Publisher	Elsevier Ltd Elsevier
Publisher_xml	– name: Elsevier Ltd – name: Elsevier
References	Dwivedi, Pandey (bib9) 2000; 294 Lindqvist, Janelidze, Hagell, Erhardt, Samuelsson, Minthon (bib20) 2009; 66 Ma, Li, Chiu, Wang, Sloane, Lu (bib21) 2006; 175 Hanke, Kielian (bib11) 2011; 121 Landreth, Reed-Geaghan (bib18) 2009; 336 Dowlati, Herrmann, Swardfager, Liu, Sham, Reim (bib8) 2010; 67 Schiepers, Wichers, Maes (bib33) 2005; 29 Rolls, Shechter, London, Ziv, Ronen, Levy (bib32) 2007; 9 Lafon, Megret, Lafage, Prehaud (bib17) 2006; 29 Okun, Griffioen, Barak, Roberts, Castro, Pita (bib26) 2010; 107 O'Neill (bib25) 2006; 18 Takeda, Kaisho, Akira (bib39) 2003; 21 Janelidze, Mattei, Westrin, Traskman-Bendz, Brundin (bib13) 2011; 25 Bosisio, Polentarutti, Sironi, Bernasconi, Miyake, Webb (bib2) 2002; 99 Alexopoulou, Holt, Medzhitov, Flavell (bib1) 2001; 413 Capuron, Raison, Musselman, Lawson, Nemeroff, Miller (bib5) 2003; 160 Crews, Qin, Sheedy, Vetreno, Zou (bib7) 2013; 73 Qureshi, Medzhitov (bib31) 2003; 4 Guo, Schluesener (bib10) 2007; 64 Bsibsi, Ravid, Gveric, van Noort (bib4) 2002; 61 Steiner, Bielau, Brisch, Danos, Ullrich, Mawrin (bib36) 2008; 42 Kawai, Akira (bib14) 2007; 19 Tahara, Kim, Jin, Maxwell, Li, Fukuchi (bib37) 2006; 129 Klune, Dhupar, Cardinal, Billiar, Tsung (bib16) 2008; 14 Okun, Griffioen, Mattson (bib28) 2011; 34 Spitzer, Williams, Gibbon, First (bib35) 1992; 49 Okun, Griffioen, Lathia, Tang, Mattson, Arumugam (bib27) 2009; 59 Kielian (bib15) 2006; 83 Hoebe, Beutler (bib12) 2004; 10 Miettinen, Sareneva, Julkunen, Matikainen (bib24) 2001; 2 Shelton, Claiborne, Sidoryk-Wegrzynowicz, Reddy, Aschner, Lewis (bib34) 2010; 16 Letiembre, Liu, Walter, Hao, Pfander, Wrede (bib19) 2009; 30 Piccinini, Midwood (bib30) 2010; 2010 Valanne, Wang, Ramet (bib40) 2011; 186 Mendlovic, Mozes, Eilat, Doron, Lereya, Zakuth (bib23) 1999; 67 Takeda, Akira (bib38) 2005; 17 Marsh, Williams-Karnesky, Stenzel-Poore (bib22) 2009; 158 Crack, Bray (bib6) 2007; 85 Pandey, Rizavi, Ren, Fareed, Hoppensteadt, Roberts (bib29) 2012; 46 Bsibsi, Persoon-Deen, Verwer, Meeuwsen, Ravid, Van Noort (bib3) 2006; 53 Landreth (10.1016/j.jpsychires.2014.01.021_bib18) 2009; 336 Dwivedi (10.1016/j.jpsychires.2014.01.021_bib9) 2000; 294 Guo (10.1016/j.jpsychires.2014.01.021_bib10) 2007; 64 Miettinen (10.1016/j.jpsychires.2014.01.021_bib24) 2001; 2 Hoebe (10.1016/j.jpsychires.2014.01.021_bib12) 2004; 10 Hanke (10.1016/j.jpsychires.2014.01.021_bib11) 2011; 121 Okun (10.1016/j.jpsychires.2014.01.021_bib27) 2009; 59 O'Neill (10.1016/j.jpsychires.2014.01.021_bib25) 2006; 18 Dowlati (10.1016/j.jpsychires.2014.01.021_bib8) 2010; 67 Steiner (10.1016/j.jpsychires.2014.01.021_bib36) 2008; 42 Crews (10.1016/j.jpsychires.2014.01.021_bib7) 2013; 73 Kawai (10.1016/j.jpsychires.2014.01.021_bib14) 2007; 19 Mendlovic (10.1016/j.jpsychires.2014.01.021_bib23) 1999; 67 Bsibsi (10.1016/j.jpsychires.2014.01.021_bib4) 2002; 61 Klune (10.1016/j.jpsychires.2014.01.021_bib16) 2008; 14 Shelton (10.1016/j.jpsychires.2014.01.021_bib34) 2010; 16 Okun (10.1016/j.jpsychires.2014.01.021_bib28) 2011; 34 Piccinini (10.1016/j.jpsychires.2014.01.021_bib30) 2010; 2010 Okun (10.1016/j.jpsychires.2014.01.021_bib26) 2010; 107 Takeda (10.1016/j.jpsychires.2014.01.021_bib38) 2005; 17 Qureshi (10.1016/j.jpsychires.2014.01.021_bib31) 2003; 4 Alexopoulou (10.1016/j.jpsychires.2014.01.021_bib1) 2001; 413 Ma (10.1016/j.jpsychires.2014.01.021_bib21) 2006; 175 Schiepers (10.1016/j.jpsychires.2014.01.021_bib33) 2005; 29 Bsibsi (10.1016/j.jpsychires.2014.01.021_bib3) 2006; 53 Janelidze (10.1016/j.jpsychires.2014.01.021_bib13) 2011; 25 Valanne (10.1016/j.jpsychires.2014.01.021_bib40) 2011; 186 Rolls (10.1016/j.jpsychires.2014.01.021_bib32) 2007; 9 Capuron (10.1016/j.jpsychires.2014.01.021_bib5) 2003; 160 Kielian (10.1016/j.jpsychires.2014.01.021_bib15) 2006; 83 Pandey (10.1016/j.jpsychires.2014.01.021_bib29) 2012; 46 Bosisio (10.1016/j.jpsychires.2014.01.021_bib2) 2002; 99 Letiembre (10.1016/j.jpsychires.2014.01.021_bib19) 2009; 30 Takeda (10.1016/j.jpsychires.2014.01.021_bib39) 2003; 21 Lafon (10.1016/j.jpsychires.2014.01.021_bib17) 2006; 29 Marsh (10.1016/j.jpsychires.2014.01.021_bib22) 2009; 158 Spitzer (10.1016/j.jpsychires.2014.01.021_bib35) 1992; 49 Tahara (10.1016/j.jpsychires.2014.01.021_bib37) 2006; 129 Crack (10.1016/j.jpsychires.2014.01.021_bib6) 2007; 85 Lindqvist (10.1016/j.jpsychires.2014.01.021_bib20) 2009; 66 18822314 - Brain Res Rev. 2009 Mar;59(2):278-92 12524386 - Annu Rev Immunol. 2003;21:335-76 12832253 - Am J Psychiatry. 2003 Jul;160(7):1342-5 20015486 - Biol Psychiatry. 2010 Mar 1;67(5):446-57 16984903 - Brain. 2006 Nov;129(Pt 11):3006-19 21209287 - J Immunol. 2011 Jan 15;186(2):649-56 17440679 - Cell Mol Life Sci. 2007 May;64(9):1128-36 12618855 - Genes Immun. 2003 Mar;4(2):87-94 1637252 - Arch Gen Psychiatry. 1992 Aug;49(8):624-9 17275323 - Semin Immunol. 2007 Feb;19(1):24-32 17905482 - Neurobiol Aging. 2009 May;30(5):759-68 20706656 - Mediators Inflamm. 2010;2010. pii: 672395. doi: 10.1155/2010/672395 16541438 - J Neurosci Res. 2006 Apr;83(5):711-30 16343886 - Curr Opin Immunol. 2006 Feb;18(1):3-9 11964313 - Blood. 2002 May 1;99(9):3427-31 16482523 - Glia. 2006 May;53(7):688-95 21906753 - J Psychiatr Res. 2012 Jan;46(1):57-63 17704767 - Nat Cell Biol. 2007 Sep;9(9):1081-8 15585605 - Int Immunol. 2005 Jan;17(1):1-14 17085778 - J Mol Neurosci. 2006;29(3):185-94 18431461 - Mol Med. 2008 Jul-Aug;14(7-8):476-84 21419501 - Trends Neurosci. 2011 May;34(5):269-81 11607032 - Nature. 2001 Oct 18;413(6857):732-8 23206318 - Biol Psychiatry. 2013 Apr 1;73(7):602-12 19268915 - Biol Psychiatry. 2009 Aug 1;66(3):287-92 11607792 - Genes Immun. 2001 Oct;2(6):349-55 10232390 - Immunol Lett. 1999 Apr 1;67(2):105-8 18809468 - Neuroscience. 2009 Feb 6;158(3):1007-20 20479761 - Mol Psychiatry. 2011 Jul;16(7):751-62 17174336 - J Psychiatr Res. 2008 Jan;42(2):151-7 21745188 - Clin Sci (Lond). 2011 Nov;121(9):367-87 10871301 - J Pharmacol Exp Ther. 2000 Jul;294(1):103-16 17060494 - J Cell Biol. 2006 Oct 23;175(2):209-15 12430718 - J Neuropathol Exp Neurol. 2002 Nov;61(11):1013-21 17667932 - Immunol Cell Biol. 2007 Aug-Sep;85(6):476-80 20951793 - Brain Behav Immun. 2011 Feb;25(2):335-9 15694227 - Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17 20713712 - Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15625-30 19688332 - Curr Top Microbiol Immunol. 2009;336:137-53 15120005 - J Endotoxin Res. 2004;10(2):130-6
References_xml	– volume: 4 start-page: 87 year: 2003 end-page: 94 ident: bib31 article-title: Toll-like receptors and their role in experimental models of microbial infection publication-title: Genes Immun – volume: 53 start-page: 688 year: 2006 end-page: 695 ident: bib3 article-title: Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators publication-title: Glia – volume: 67 start-page: 105 year: 1999 end-page: 108 ident: bib23 article-title: Immune activation in non-treated suicidal major depression publication-title: Immunol Lett – volume: 49 start-page: 624 year: 1992 end-page: 629 ident: bib35 article-title: The structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description publication-title: Arch Gen Psychiatry – volume: 14 start-page: 476 year: 2008 end-page: 484 ident: bib16 article-title: HMGB1: endogenous danger signaling publication-title: Mol Med – volume: 59 start-page: 278 year: 2009 end-page: 292 ident: bib27 article-title: Toll-like receptors in neurodegeneration publication-title: Brain Res Rev – volume: 2 start-page: 349 year: 2001 end-page: 355 ident: bib24 article-title: IFNs activate toll-like receptor gene expression in viral infections publication-title: Genes Immun – volume: 129 start-page: 3006 year: 2006 end-page: 3019 ident: bib37 article-title: Role of toll-like receptor signalling in Abeta uptake and clearance publication-title: Brain – volume: 9 start-page: 1081 year: 2007 end-page: 1088 ident: bib32 article-title: Toll-like receptors modulate adult hippocampal neurogenesis publication-title: Nat Cell Biol – volume: 67 start-page: 446 year: 2010 end-page: 457 ident: bib8 article-title: A meta-analysis of cytokines in major depression publication-title: Biol Psychiatry – volume: 121 start-page: 367 year: 2011 end-page: 387 ident: bib11 article-title: Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential publication-title: Clin Sci (Lond) – volume: 336 start-page: 137 year: 2009 end-page: 153 ident: bib18 article-title: Toll-like receptors in Alzheimer's disease publication-title: Curr Top Microbiol Immunol – volume: 85 start-page: 476 year: 2007 end-page: 480 ident: bib6 article-title: Toll-like receptors in the brain and their potential roles in neuropathology publication-title: Immunol Cell Biol – volume: 19 start-page: 24 year: 2007 end-page: 32 ident: bib14 article-title: TLR signaling publication-title: Semin Immunol – volume: 83 start-page: 711 year: 2006 end-page: 730 ident: bib15 article-title: Toll-like receptors in central nervous system glial inflammation and homeostasis publication-title: J Neurosci Res – volume: 413 start-page: 732 year: 2001 end-page: 738 ident: bib1 article-title: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 publication-title: Nature – volume: 158 start-page: 1007 year: 2009 end-page: 1020 ident: bib22 article-title: Toll-like receptor signaling in endogenous neuroprotection and stroke publication-title: Neuroscience – volume: 29 start-page: 185 year: 2006 end-page: 194 ident: bib17 article-title: The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA publication-title: J Mol Neurosci – volume: 25 start-page: 335 year: 2011 end-page: 339 ident: bib13 article-title: Cytokine levels in the blood may distinguish suicide attempters from depressed patients publication-title: Brain Behav Immun – volume: 66 start-page: 287 year: 2009 end-page: 292 ident: bib20 article-title: Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity publication-title: Biol Psychiatry – volume: 46 start-page: 57 year: 2012 end-page: 63 ident: bib29 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J Psychiatr Res – volume: 34 start-page: 269 year: 2011 end-page: 281 ident: bib28 article-title: Toll-like receptor signaling in neural plasticity and disease publication-title: Trends Neurosci – volume: 17 start-page: 1 year: 2005 end-page: 14 ident: bib38 article-title: Toll-like receptors in innate immunity publication-title: Int Immunol – volume: 2010 year: 2010 ident: bib30 article-title: DAMPening inflammation by modulating TLR signalling publication-title: Mediat Inflamm – volume: 29 start-page: 201 year: 2005 end-page: 217 ident: bib33 article-title: Cytokines and major depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 16 start-page: 751 year: 2010 end-page: 762 ident: bib34 article-title: Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression publication-title: Mol Psychiatry – volume: 294 start-page: 103 year: 2000 end-page: 116 ident: bib9 article-title: Adrenal glucocorticoids modulate [3H]cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain publication-title: J Pharmacol Exp Ther – volume: 64 start-page: 1128 year: 2007 end-page: 1136 ident: bib10 article-title: The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors publication-title: Cell Mol Life Sci – volume: 10 start-page: 130 year: 2004 end-page: 136 ident: bib12 article-title: LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins publication-title: J Endotoxin Res – volume: 18 start-page: 3 year: 2006 end-page: 9 ident: bib25 article-title: How Toll-like receptors signal: what we know and what we don't know publication-title: Curr Opin Immunol – volume: 61 start-page: 1013 year: 2002 end-page: 1021 ident: bib4 article-title: Broad expression of Toll-like receptors in the human central nervous system publication-title: J Neuropathol Exp Neurol – volume: 21 start-page: 335 year: 2003 end-page: 376 ident: bib39 article-title: Toll-like receptors publication-title: Annu Rev Immunol – volume: 107 start-page: 15625 year: 2010 end-page: 15630 ident: bib26 article-title: Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis publication-title: Proc Natl Acad Sci U S A – volume: 73 start-page: 602 year: 2013 end-page: 612 ident: bib7 article-title: High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence publication-title: Biol Psychiatry – volume: 186 start-page: 649 year: 2011 end-page: 656 ident: bib40 article-title: The Drosophila toll signaling pathway publication-title: J Immunol – volume: 99 start-page: 3427 year: 2002 end-page: 3431 ident: bib2 article-title: Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide publication-title: Blood – volume: 160 start-page: 1342 year: 2003 end-page: 1345 ident: bib5 article-title: Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy publication-title: Am J Psychiatry – volume: 30 start-page: 759 year: 2009 end-page: 768 ident: bib19 article-title: Screening of innate immune receptors in neurodegenerative diseases: a similar pattern publication-title: Neurobiol Aging – volume: 175 start-page: 209 year: 2006 end-page: 215 ident: bib21 article-title: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis publication-title: J Cell Biol – volume: 42 start-page: 151 year: 2008 end-page: 157 ident: bib36 article-title: Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide publication-title: J Psychiatr Res – volume: 53 start-page: 688 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib3 article-title: Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators publication-title: Glia doi: 10.1002/glia.20328 – volume: 14 start-page: 476 year: 2008 ident: 10.1016/j.jpsychires.2014.01.021_bib16 article-title: HMGB1: endogenous danger signaling publication-title: Mol Med doi: 10.2119/2008-00034.Klune – volume: 61 start-page: 1013 year: 2002 ident: 10.1016/j.jpsychires.2014.01.021_bib4 article-title: Broad expression of Toll-like receptors in the human central nervous system publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/61.11.1013 – volume: 73 start-page: 602 year: 2013 ident: 10.1016/j.jpsychires.2014.01.021_bib7 article-title: High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2012.09.030 – volume: 85 start-page: 476 year: 2007 ident: 10.1016/j.jpsychires.2014.01.021_bib6 article-title: Toll-like receptors in the brain and their potential roles in neuropathology publication-title: Immunol Cell Biol doi: 10.1038/sj.icb.7100103 – volume: 19 start-page: 24 year: 2007 ident: 10.1016/j.jpsychires.2014.01.021_bib14 article-title: TLR signaling publication-title: Semin Immunol doi: 10.1016/j.smim.2006.12.004 – volume: 59 start-page: 278 year: 2009 ident: 10.1016/j.jpsychires.2014.01.021_bib27 article-title: Toll-like receptors in neurodegeneration publication-title: Brain Res Rev doi: 10.1016/j.brainresrev.2008.09.001 – volume: 9 start-page: 1081 year: 2007 ident: 10.1016/j.jpsychires.2014.01.021_bib32 article-title: Toll-like receptors modulate adult hippocampal neurogenesis publication-title: Nat Cell Biol doi: 10.1038/ncb1629 – volume: 336 start-page: 137 year: 2009 ident: 10.1016/j.jpsychires.2014.01.021_bib18 article-title: Toll-like receptors in Alzheimer's disease publication-title: Curr Top Microbiol Immunol – volume: 2010 year: 2010 ident: 10.1016/j.jpsychires.2014.01.021_bib30 article-title: DAMPening inflammation by modulating TLR signalling publication-title: Mediat Inflamm doi: 10.1155/2010/672395 – volume: 25 start-page: 335 year: 2011 ident: 10.1016/j.jpsychires.2014.01.021_bib13 article-title: Cytokine levels in the blood may distinguish suicide attempters from depressed patients publication-title: Brain Behav Immun doi: 10.1016/j.bbi.2010.10.010 – volume: 21 start-page: 335 year: 2003 ident: 10.1016/j.jpsychires.2014.01.021_bib39 article-title: Toll-like receptors publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.21.120601.141126 – volume: 67 start-page: 105 year: 1999 ident: 10.1016/j.jpsychires.2014.01.021_bib23 article-title: Immune activation in non-treated suicidal major depression publication-title: Immunol Lett doi: 10.1016/S0165-2478(98)00145-X – volume: 83 start-page: 711 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib15 article-title: Toll-like receptors in central nervous system glial inflammation and homeostasis publication-title: J Neurosci Res doi: 10.1002/jnr.20767 – volume: 175 start-page: 209 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib21 article-title: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis publication-title: J Cell Biol doi: 10.1083/jcb.200606016 – volume: 17 start-page: 1 year: 2005 ident: 10.1016/j.jpsychires.2014.01.021_bib38 article-title: Toll-like receptors in innate immunity publication-title: Int Immunol doi: 10.1093/intimm/dxh186 – volume: 99 start-page: 3427 year: 2002 ident: 10.1016/j.jpsychires.2014.01.021_bib2 article-title: Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide publication-title: Blood doi: 10.1182/blood.V99.9.3427 – volume: 30 start-page: 759 year: 2009 ident: 10.1016/j.jpsychires.2014.01.021_bib19 article-title: Screening of innate immune receptors in neurodegenerative diseases: a similar pattern publication-title: Neurobiol Aging doi: 10.1016/j.neurobiolaging.2007.08.018 – volume: 42 start-page: 151 year: 2008 ident: 10.1016/j.jpsychires.2014.01.021_bib36 article-title: Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2006.10.013 – volume: 186 start-page: 649 year: 2011 ident: 10.1016/j.jpsychires.2014.01.021_bib40 article-title: The Drosophila toll signaling pathway publication-title: J Immunol doi: 10.4049/jimmunol.1002302 – volume: 64 start-page: 1128 year: 2007 ident: 10.1016/j.jpsychires.2014.01.021_bib10 article-title: The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors publication-title: Cell Mol Life Sci doi: 10.1007/s00018-007-6494-3 – volume: 4 start-page: 87 year: 2003 ident: 10.1016/j.jpsychires.2014.01.021_bib31 article-title: Toll-like receptors and their role in experimental models of microbial infection publication-title: Genes Immun doi: 10.1038/sj.gene.6363937 – volume: 413 start-page: 732 year: 2001 ident: 10.1016/j.jpsychires.2014.01.021_bib1 article-title: Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 publication-title: Nature doi: 10.1038/35099560 – volume: 10 start-page: 130 year: 2004 ident: 10.1016/j.jpsychires.2014.01.021_bib12 article-title: LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins publication-title: J Endotoxin Res doi: 10.1177/09680519040100021001 – volume: 34 start-page: 269 year: 2011 ident: 10.1016/j.jpsychires.2014.01.021_bib28 article-title: Toll-like receptor signaling in neural plasticity and disease publication-title: Trends Neurosci doi: 10.1016/j.tins.2011.02.005 – volume: 67 start-page: 446 year: 2010 ident: 10.1016/j.jpsychires.2014.01.021_bib8 article-title: A meta-analysis of cytokines in major depression publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2009.09.033 – volume: 160 start-page: 1342 year: 2003 ident: 10.1016/j.jpsychires.2014.01.021_bib5 article-title: Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.160.7.1342 – volume: 18 start-page: 3 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib25 article-title: How Toll-like receptors signal: what we know and what we don't know publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2005.11.012 – volume: 16 start-page: 751 year: 2010 ident: 10.1016/j.jpsychires.2014.01.021_bib34 article-title: Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression publication-title: Mol Psychiatry doi: 10.1038/mp.2010.52 – volume: 49 start-page: 624 year: 1992 ident: 10.1016/j.jpsychires.2014.01.021_bib35 article-title: The structured clinical interview for DSM-III-R (SCID). I: history, rationale, and description publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1992.01820080032005 – volume: 2 start-page: 349 year: 2001 ident: 10.1016/j.jpsychires.2014.01.021_bib24 article-title: IFNs activate toll-like receptor gene expression in viral infections publication-title: Genes Immun doi: 10.1038/sj.gene.6363791 – volume: 129 start-page: 3006 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib37 article-title: Role of toll-like receptor signalling in Abeta uptake and clearance publication-title: Brain doi: 10.1093/brain/awl249 – volume: 294 start-page: 103 year: 2000 ident: 10.1016/j.jpsychires.2014.01.021_bib9 article-title: Adrenal glucocorticoids modulate [3H]cyclic AMP binding to protein kinase A (PKA), cyclic AMP-dependent PKA activity, and protein levels of selective regulatory and catalytic subunit isoforms of PKA in rat brain publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(24)39045-7 – volume: 158 start-page: 1007 year: 2009 ident: 10.1016/j.jpsychires.2014.01.021_bib22 article-title: Toll-like receptor signaling in endogenous neuroprotection and stroke publication-title: Neuroscience doi: 10.1016/j.neuroscience.2008.07.067 – volume: 29 start-page: 201 year: 2005 ident: 10.1016/j.jpsychires.2014.01.021_bib33 article-title: Cytokines and major depression publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2004.11.003 – volume: 121 start-page: 367 year: 2011 ident: 10.1016/j.jpsychires.2014.01.021_bib11 article-title: Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential publication-title: Clin Sci (Lond) doi: 10.1042/CS20110164 – volume: 107 start-page: 15625 year: 2010 ident: 10.1016/j.jpsychires.2014.01.021_bib26 article-title: Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1005807107 – volume: 46 start-page: 57 year: 2012 ident: 10.1016/j.jpsychires.2014.01.021_bib29 article-title: Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims publication-title: J Psychiatr Res doi: 10.1016/j.jpsychires.2011.08.006 – volume: 66 start-page: 287 year: 2009 ident: 10.1016/j.jpsychires.2014.01.021_bib20 article-title: Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2009.01.030 – volume: 29 start-page: 185 year: 2006 ident: 10.1016/j.jpsychires.2014.01.021_bib17 article-title: The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA publication-title: J Mol Neurosci doi: 10.1385/JMN:29:3:185 – reference: 16541438 - J Neurosci Res. 2006 Apr;83(5):711-30 – reference: 12524386 - Annu Rev Immunol. 2003;21:335-76 – reference: 16482523 - Glia. 2006 May;53(7):688-95 – reference: 10871301 - J Pharmacol Exp Ther. 2000 Jul;294(1):103-16 – reference: 17704767 - Nat Cell Biol. 2007 Sep;9(9):1081-8 – reference: 10232390 - Immunol Lett. 1999 Apr 1;67(2):105-8 – reference: 15120005 - J Endotoxin Res. 2004;10(2):130-6 – reference: 21906753 - J Psychiatr Res. 2012 Jan;46(1):57-63 – reference: 17667932 - Immunol Cell Biol. 2007 Aug-Sep;85(6):476-80 – reference: 15694227 - Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17 – reference: 19688332 - Curr Top Microbiol Immunol. 2009;336:137-53 – reference: 21209287 - J Immunol. 2011 Jan 15;186(2):649-56 – reference: 20706656 - Mediators Inflamm. 2010;2010. pii: 672395. doi: 10.1155/2010/672395 – reference: 20479761 - Mol Psychiatry. 2011 Jul;16(7):751-62 – reference: 16984903 - Brain. 2006 Nov;129(Pt 11):3006-19 – reference: 17174336 - J Psychiatr Res. 2008 Jan;42(2):151-7 – reference: 20015486 - Biol Psychiatry. 2010 Mar 1;67(5):446-57 – reference: 20713712 - Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15625-30 – reference: 21419501 - Trends Neurosci. 2011 May;34(5):269-81 – reference: 18809468 - Neuroscience. 2009 Feb 6;158(3):1007-20 – reference: 11607792 - Genes Immun. 2001 Oct;2(6):349-55 – reference: 18431461 - Mol Med. 2008 Jul-Aug;14(7-8):476-84 – reference: 12430718 - J Neuropathol Exp Neurol. 2002 Nov;61(11):1013-21 – reference: 12618855 - Genes Immun. 2003 Mar;4(2):87-94 – reference: 17905482 - Neurobiol Aging. 2009 May;30(5):759-68 – reference: 17440679 - Cell Mol Life Sci. 2007 May;64(9):1128-36 – reference: 19268915 - Biol Psychiatry. 2009 Aug 1;66(3):287-92 – reference: 12832253 - Am J Psychiatry. 2003 Jul;160(7):1342-5 – reference: 11964313 - Blood. 2002 May 1;99(9):3427-31 – reference: 23206318 - Biol Psychiatry. 2013 Apr 1;73(7):602-12 – reference: 16343886 - Curr Opin Immunol. 2006 Feb;18(1):3-9 – reference: 1637252 - Arch Gen Psychiatry. 1992 Aug;49(8):624-9 – reference: 11607032 - Nature. 2001 Oct 18;413(6857):732-8 – reference: 18822314 - Brain Res Rev. 2009 Mar;59(2):278-92 – reference: 17085778 - J Mol Neurosci. 2006;29(3):185-94 – reference: 20951793 - Brain Behav Immun. 2011 Feb;25(2):335-9 – reference: 15585605 - Int Immunol. 2005 Jan;17(1):1-14 – reference: 17060494 - J Cell Biol. 2006 Oct 23;175(2):209-15 – reference: 21745188 - Clin Sci (Lond). 2011 Nov;121(9):367-87 – reference: 17275323 - Semin Immunol. 2007 Feb;19(1):24-32
SSID	ssj0007214
Score	2.4772491
Snippet	Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines in the... Abstract Abnormalities of the immune function in depression and suicide are based in part on the observation of increased levels of proinflammatory cytokines...
SourceID	pubmedcentral proquest pubmed pascalfrancis crossref elsevier
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	62
SubjectTerms	Adult Adult and adolescent clinical studies Aged Analysis of Variance Antidepressive Agents - therapeutic use Biological and medical sciences Cortex Cytokines Depression Depression - pathology Depression - psychology Ethanol - pharmacology Female Gene Expression - drug effects Gene Expression - physiology Humans Innate immunity Male Medical sciences Middle Aged Miscellaneous Mood disorders Postmortem brain Postmortems Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Proteins Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - metabolism Suicide Suicide - psychology Toll-like receptors (TLRs) Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Victims Young Adult
Title	Toll-like receptors in the depressed and suicide brain
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0022395614000302 https://www.clinicalkey.es/playcontent/1-s2.0-S0022395614000302 https://dx.doi.org/10.1016/j.jpsychires.2014.01.021 https://www.ncbi.nlm.nih.gov/pubmed/24565447 https://www.proquest.com/docview/1513051570 https://www.proquest.com/docview/1534806944 https://www.proquest.com/docview/1541979299 https://pubmed.ncbi.nlm.nih.gov/PMC4004369
Volume	53
WOSCitedRecordID	wos000335104200009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-1379 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007214 issn: 0022-3956 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1ba9swFBZpO8ZgjN2XXYIHeysuli1HFnsqXXejLWXrRt6EbMnEWeOEJA7tYP99R5asJG1WssFeTLCt2NL5fHQkffoOQm8wBKEyyJgvg0j6JAcYp7kI_DwTXZmoLMU1Qfb7ET05SXo9dtpq_Wr2wszPaVkmFxds_F9NDefA2Hrr7F-Y2_0pnIDfYHQ4gtnhuJnhwbL-UfFDJ2TQnBWdTceSGd8Z2quShrBZFVkhNT1AWPnt60GqI0PXSs9LM1_1qlMpzYT3hz50eP1LMdw92XMrOMVPMTcpsUejSXEp-rtfFxeNs-tBv1mN3IxAX1TDovbOXyqT1LuZj8BkwZta3h_AYitwbdxqQpmPI5M2pvG7cbTkOK1LNl2wSbRzzbmbeYbB3sDUHWqtqXnEyK7i5SJgkfGwtm-9rkuMqOcVYe3T4wNSK_CzLbQT0piBU9zZ_3TY--y6chgeEyc3D1WyVDBDEFz_Glpd2j7zT6HO3bGYwgeYm8wp64Y2Vxm6SyHP2X10z8LA2zcYe4BaqnyIbh9bNsYj1HVQ8xzUvKL0AGqeg5oHKPEs1Lwaao_Rt_eHZwcffZuHw8-gP5j5NFJxmnaDhIaRkioXMGanaRKkMLrNI8EojiSBYUOc4AwC8pwwnEuaCLhFJlLG0RO0XY5K9Qx5imRZoHAoWAyhrBRpHIpIKpwEWVcrF7YRbZqMZ1akXudKOecNG3HAF-3OdbvzAHNo9zbCruTYCLVsUIY1VuHNRmToOjkAboOydF1ZNbWuYMoxn4Y84JoOEWrwYFJPQIRt9NaVtGGuCV83fG5nBT6uslo4MY66URu9bvDEoavQ63-iVKMKXiiGgBXGLzS46Z6IJHozPLnpHoIZhXEVa6OnBqeLt7DYh-ZZQbC7QcvZr14pi34ta28_xuf_XPIFurNwSC_R9mxSqVfoVjafFdNJB23RXtKxX_hvg4scYQ
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Toll-Like+Receptors+in+the+Depressed+and+Suicide+Brain&rft.jtitle=Journal+of+psychiatric+research&rft.au=Pandey%2C+Ghanshyam+N.&rft.au=Rizavi%2C+Hooriyah+S.&rft.au=Ren%2C+Xinguo&rft.au=Bhaumik%2C+Runa&rft.date=2014-06-01&rft.issn=0022-3956&rft.eissn=1879-1379&rft.volume=53&rft.spage=62&rft.epage=68&rft_id=info:doi/10.1016%2Fj.jpsychires.2014.01.021&rft_id=info%3Apmid%2F24565447&rft.externalDocID=PMC4004369
thumbnail_m	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00223956%2FS0022395614X00051%2Fcov150h.gif