Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs

During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this are...

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Bibliographic Details
Published in:The Journal of clinical investigation Vol. 124; no. 11; pp. 4678 - 4680
Main Authors: Akdis, Cezmi A., Akdis, Mübeccel
Format: Journal Article
Language:English
Published: United States American Society for Clinical Investigation 01.11.2014
Subjects:
Allergens
Allergens - immunology
Allergies
Animals
Autoimmune diseases
Biomedical research
Health aspects
Hindsight
Humans
Immune system
Immune Tolerance
Immunity, Cellular
Immunotherapy
Interleukin-10
Interleukin-10 - physiology
Physiological aspects
T cells
T-Lymphocytes, Regulatory - physiology
Switzerland
ISSN:0021-9738, 1558-8238, 1558-8238
Online Access:Get full text
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Summary:During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-β, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.
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ISSN:0021-9738
1558-8238
1558-8238
DOI:10.1172/JCI78891