MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis

Accumulation of IL-17-producing Th17 cells is associated with the development of multiple autoimmune diseases; however, the contribution of microRNA (miRNA) pathways to the intrinsic control of Th17 development remains unclear. Here, we demonstrated that miR-21 expression is elevated in Th17 cells a...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 125; no. 3; pp. 1069 - 1080
Main Authors:	Murugaiyan, Gopal, da Cunha, Andre Pires, Ajay, Amrendra K., Joller, Nicole, Garo, Lucien P., Kumaradevan, Sowmiya, Yosef, Nir, Vaidya, Vishal S., Weiner, Howard L.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.03.2015
Subjects:	Animals Autoimmune diseases Base Sequence Binding Sites Biomedical research Care and treatment Cell Differentiation Cells, Cultured Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Female Gene Expression Hospitals Immune system Interleukin-17 - genetics Interleukin-17 - metabolism Lymphocytes Mice, Inbred C57BL MicroRNA MicroRNAs - physiology Physiological aspects Rheumatology RNA Interference Smad7 Protein - genetics Smad7 Protein - metabolism Studies Th17 Cells - physiology Transcription factors
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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