DNA methylation profiling in the clinic: applications and challenges

Key Points Alterations in epigenetic marks — specifically DNA methylation — are an emerging biomarker that may be used in the decision-making process for disease diagnosis, prognosis and treatment, most notably in cancer, but there are examples in other diseases, such as type 1 diabetes. Alterations...

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Vydáno v:	Nature reviews. Genetics Ročník 13; číslo 10; s. 679 - 692
Hlavní autoři:	Heyn, Holger, Esteller, Manel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.10.2012 Nature Publishing Group
Témata:	631/208/176/1988 631/208/191/2018 631/208/721 Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Clinical Laboratory Techniques - methods Clinical Laboratory Techniques - standards Datasets Disease Disease - genetics DNA DNA methylation DNA Methylation - physiology Epigenesis, Genetic - physiology Epigenetic inheritance Epigenetics Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Function Genes Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Human Genetics Humans Medical diagnosis Methylation Models, Biological Molecular Targeted Therapy - methods Molecular Targeted Therapy - trends Mutation Prostate cancer review-article Spain Methylation DNA Review
ISSN:	1471-0056, 1471-0064, 1471-0064
On-line přístup:	Získat plný text
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