DNA methylation profiling in the clinic: applications and challenges

Key Points Alterations in epigenetic marks — specifically DNA methylation — are an emerging biomarker that may be used in the decision-making process for disease diagnosis, prognosis and treatment, most notably in cancer, but there are examples in other diseases, such as type 1 diabetes. Alterations...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 13; no. 10; pp. 679 - 692
Main Authors:	Heyn, Holger, Esteller, Manel
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2012 Nature Publishing Group
Subjects:	631/208/176/1988 631/208/191/2018 631/208/721 Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Clinical Laboratory Techniques - methods Clinical Laboratory Techniques - standards Datasets Disease Disease - genetics DNA DNA methylation DNA Methylation - physiology Epigenesis, Genetic - physiology Epigenetic inheritance Epigenetics Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Function Genes Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Human Genetics Humans Medical diagnosis Methylation Models, Biological Molecular Targeted Therapy - methods Molecular Targeted Therapy - trends Mutation Prostate cancer review-article Spain Methylation DNA Review
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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