Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research

Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a m...

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Vydáno v:Journal of the American Medical Directors Association Ročník 16; číslo 8; s. 640 - 647
Hlavní autoři: Fabbri, Elisa, Zoli, Marco, Gonzalez-Freire, Marta, Salive, Marcel E, Studenski, Stephanie A, Ferrucci, Luigi
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.2015
Témata:
Aged
Aging - physiology
Biomedical Research
Chronic Disease
Comorbidity
Humans
Risk Factors
aging
multiple morbidities
chronic disease
Multimorbidity
ISSN:1538-9375
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Shrnutí:Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities.
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ISSN:1538-9375
DOI:10.1016/j.jamda.2015.03.013