Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research
Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a m...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Medical Directors Association Jg. 16; H. 8; S. 640 - 647 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
01.08.2015
|
| Schlagworte: | |
| ISSN: | 1538-9375 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities. |
|---|---|
| AbstractList | Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for multimorbidity. From a gerontological perspective, the progressive accumulation of multiple diseases, which significantly accelerates at older ages, is a milestone for progressive loss of resilience and age-related multisystem homeostatic dysregulation. Because it is most likely that the same mechanisms that drive aging also drive multiple age-related chronic diseases, addressing those mechanisms may reduce the development of multimorbidity. According to this vision, studying multimorbidity may help to understand the biology of aging and, at the same time, understanding the underpinnings of aging may help to develop strategies to prevent or delay the burden of multimorbidity. As a consequence, we believe that it is time to build connections and dialogue between the clinical experience of general practitioners and geriatricians and the scientists who study aging, so as to stimulate innovative research projects to improve the management and the treatment of older patients with multiple morbidities. |
| Author | Gonzalez-Freire, Marta Fabbri, Elisa Zoli, Marco Studenski, Stephanie A Salive, Marcel E Ferrucci, Luigi |
| Author_xml | – sequence: 1 givenname: Elisa surname: Fabbri fullname: Fabbri, Elisa organization: Translational Gerontology Branch, Longitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy – sequence: 2 givenname: Marco surname: Zoli fullname: Zoli, Marco organization: Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy – sequence: 3 givenname: Marta surname: Gonzalez-Freire fullname: Gonzalez-Freire, Marta organization: Translational Gerontology Branch, Longitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD – sequence: 4 givenname: Marcel E surname: Salive fullname: Salive, Marcel E organization: Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, MD – sequence: 5 givenname: Stephanie A surname: Studenski fullname: Studenski, Stephanie A organization: Translational Gerontology Branch, Longitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD – sequence: 6 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi email: ferrucilu@grc.nia.nih.gov organization: Translational Gerontology Branch, Longitudinal Study Section, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD. Electronic address: ferrucilu@grc.nia.nih.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25958334$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kMtOwzAQRS0Eog_4AiTkJQsSbCd2YnZVRUul8hAq68hJJsElsYudCPXvSaGsZs69R7OYCTo11gBCV5SElFBxtw23qi1VyAjlIYlCQqMTNKY8SgMZJXyEJt5vCRlqKc7RiHHJ0yiKx8jNam1qrEyJn_qm0611uS51t7_Hz_CNN8p_-lv86rR1utMw7Ad14awZyHlcWYdXpoPaqQ5KvIRDYxtb60I1v-680eYX3sCDcsXHBTqrVOPh8jin6H3xsJk_BuuX5Wo-WwdFQlgXMF4kqWCg0jyveJJLUIrTsuSVGFjEImJM5ENEQbIkpaLKOchKxAljihSKTdHN392ds189-C5rtS-gaZQB2_uMCiljyaUUg3p9VPu8hTLbOd0qt8_-_8R-ABZabJo |
| CitedBy_id | crossref_primary_10_7717_peerj_17536 crossref_primary_10_1007_s40520_023_02541_5 crossref_primary_10_1016_j_chest_2018_10_006 crossref_primary_10_1002_ana_25071 crossref_primary_10_1017_S1463423625100467 crossref_primary_10_1111_jgs_16255 crossref_primary_10_1016_j_jclinepi_2018_09_008 crossref_primary_10_1038_s41598_018_32537_5 crossref_primary_10_3390_jcm13144202 crossref_primary_10_1016_j_chiabu_2024_107100 crossref_primary_10_1111_jvh_13930 crossref_primary_10_1007_s12603_021_1638_y crossref_primary_10_1186_s12913_021_06140_w crossref_primary_10_1002_jppr_1597 crossref_primary_10_3390_healthcare10081440 crossref_primary_10_1177_0898010120942965 crossref_primary_10_1186_s12939_023_02024_z crossref_primary_10_3390_nu14245319 crossref_primary_10_1016_j_ypmed_2020_106330 crossref_primary_10_3390_nu16040496 crossref_primary_10_1093_aje_kwac143 crossref_primary_10_1016_j_fertnstert_2024_08_345 crossref_primary_10_1177_07334648231161929 crossref_primary_10_1016_j_mad_2016_07_005 crossref_primary_10_3389_fcell_2018_00178 crossref_primary_10_3389_fnut_2022_946245 crossref_primary_10_1097_MLR_0000000000001836 crossref_primary_10_1016_j_arr_2020_101037 crossref_primary_10_1002_j_2040_4603_2022_tb00211_x crossref_primary_10_1016_j_jad_2021_09_067 crossref_primary_10_1002_pds_70133 crossref_primary_10_1371_journal_pone_0243614 crossref_primary_10_1080_09638288_2024_2423770 crossref_primary_10_1007_s00391_016_1129_7 crossref_primary_10_1016_j_rce_2017_01_007 crossref_primary_10_1001_jamanetworkopen_2019_15245 crossref_primary_10_1186_s12889_024_18006_x crossref_primary_10_4103_jgmh_jgmh_1_20 crossref_primary_10_12788_acp_0089 crossref_primary_10_3389_ijph_2024_1606660 crossref_primary_10_1002_wmh3_639 crossref_primary_10_1093_jamia_ocae182 crossref_primary_10_1007_s40520_020_01495_2 crossref_primary_10_1186_s12877_025_06012_6 crossref_primary_10_1146_annurev_animal_051021_080937 crossref_primary_10_2196_27146 crossref_primary_10_1136_jech_2023_221060 crossref_primary_10_1016_j_mad_2020_111391 crossref_primary_10_1093_eurpub_ckad179 crossref_primary_10_1177_0898264320983663 crossref_primary_10_1111_joim_12843 crossref_primary_10_1177_01410768241233109 crossref_primary_10_1080_17512433_2023_2286321 crossref_primary_10_1177_08982643231180045 crossref_primary_10_3390_healthcare13161999 crossref_primary_10_2147_PPA_S363082 crossref_primary_10_3389_fpubh_2023_1031457 crossref_primary_10_3389_fmed_2025_1483366 crossref_primary_10_1016_j_mad_2020_111383 crossref_primary_10_1016_j_puhe_2017_11_014 crossref_primary_10_1016_j_jamda_2015_05_022 crossref_primary_10_1136_bmjgh_2020_002414 crossref_primary_10_1177_23333928231178774 crossref_primary_10_1186_s12916_025_03853_1 crossref_primary_10_1111_jgs_16919 crossref_primary_10_2196_jmir_6989 crossref_primary_10_1007_s12652_019_01573_y crossref_primary_10_1038_s41598_022_24719_z crossref_primary_10_23736_S0021_9509_21_11826_9 crossref_primary_10_1016_j_jdsr_2019_12_001 crossref_primary_10_1002_acr_24973 crossref_primary_10_1111_jep_13460 crossref_primary_10_1136_bmjopen_2023_074902 crossref_primary_10_3390_jcm9082669 crossref_primary_10_1038_nm_4004 crossref_primary_10_1093_ageing_afac315 crossref_primary_10_1016_j_arr_2021_101405 crossref_primary_10_3390_antiox12030651 crossref_primary_10_1177_1357633X241236572 crossref_primary_10_1093_geronb_gbx118 crossref_primary_10_1007_s11136_024_03598_z crossref_primary_10_1111_ggi_70077 crossref_primary_10_1016_j_cger_2016_01_008 crossref_primary_10_1093_abm_kaaf045 crossref_primary_10_1186_s12986_024_00845_5 crossref_primary_10_1016_j_rceng_2017_01_001 crossref_primary_10_1093_gerona_glaf164 crossref_primary_10_1093_jn_nxab158 crossref_primary_10_1016_j_amjmed_2019_05_005 crossref_primary_10_1136_bmjopen_2020_042633 crossref_primary_10_3390_vaccines10101665 crossref_primary_10_1016_j_jamda_2021_02_030 crossref_primary_10_1186_s12877_022_02793_2 crossref_primary_10_1213_ANE_0000000000007228 crossref_primary_10_3390_ijerph17197053 crossref_primary_10_1016_j_archger_2020_104325 crossref_primary_10_1016_j_jamda_2016_07_019 crossref_primary_10_4102_safp_v62i1_5081 crossref_primary_10_1080_10376178_2020_1812416 crossref_primary_10_1016_j_hfh_2025_100100 crossref_primary_10_1016_j_jamda_2017_06_033 crossref_primary_10_1016_j_ebiom_2017_06_015 crossref_primary_10_1111_jan_14931 crossref_primary_10_1186_s12889_023_15136_6 crossref_primary_10_1111_1747_0080_12590 crossref_primary_10_1080_13607863_2021_1901260 crossref_primary_10_1111_jan_14385 crossref_primary_10_1183_13993003_02569_2017 crossref_primary_10_1016_j_exger_2016_02_006 crossref_primary_10_1016_j_hrtlng_2018_09_004 crossref_primary_10_1016_j_jamda_2016_07_011 crossref_primary_10_1186_s12889_022_12722_y crossref_primary_10_3390_biomedicines10123127 crossref_primary_10_1007_s11605_023_05820_8 crossref_primary_10_1093_fampra_cmaf027 crossref_primary_10_1111_jgs_14092 crossref_primary_10_1186_s12889_023_15502_4 crossref_primary_10_3389_fcvm_2021_688483 crossref_primary_10_1186_s13098_024_01288_x crossref_primary_10_1007_s10552_025_01970_z crossref_primary_10_1371_journal_pone_0324548 crossref_primary_10_3390_jpm13010027 crossref_primary_10_7759_cureus_21846 crossref_primary_10_1002_gps_5837 crossref_primary_10_1177_0898264316680903 crossref_primary_10_1007_s00586_023_07618_3 crossref_primary_10_1016_j_dld_2022_10_012 crossref_primary_10_1002_wmh3_557 crossref_primary_10_1111_ijcp_13714 crossref_primary_10_3390_geriatrics2020015 crossref_primary_10_1016_j_colegn_2018_07_009 crossref_primary_10_3389_fnagi_2022_840386 crossref_primary_10_1007_s10433_023_00781_y crossref_primary_10_1016_j_bspc_2025_108289 crossref_primary_10_1038_s41393_021_00704_7 crossref_primary_10_1186_s12877_020_01972_3 crossref_primary_10_1007_s00384_025_04933_7 crossref_primary_10_1186_s12889_019_6567_x crossref_primary_10_1007_s00394_021_02565_5 crossref_primary_10_1007_s11605_020_04590_x crossref_primary_10_1111_hex_13743 crossref_primary_10_1371_journal_pone_0271639 crossref_primary_10_1177_2235042X19873486 crossref_primary_10_1080_17512433_2018_1425138 crossref_primary_10_1007_s40801_020_00220_9 crossref_primary_10_1371_journal_pone_0253795 crossref_primary_10_1097_MD_0000000000044303 crossref_primary_10_1186_s12875_018_0790_x crossref_primary_10_1177_26335565251339236 crossref_primary_10_1186_s13195_018_0373_z crossref_primary_10_1016_j_arr_2016_09_008 crossref_primary_10_1017_erm_2022_36 crossref_primary_10_1177_2235042X19872030 crossref_primary_10_1007_s12529_021_09985_x crossref_primary_10_1016_j_ijnurstu_2025_105019 crossref_primary_10_1186_s12877_022_02848_4 crossref_primary_10_1177_07334648221086953 crossref_primary_10_1016_j_smhs_2019_08_005 crossref_primary_10_20538_1682_0363_2022_1_162_170 crossref_primary_10_1016_j_drudis_2020_06_016 crossref_primary_10_1097_QAD_0000000000004246 crossref_primary_10_1016_j_arr_2020_101204 crossref_primary_10_1016_j_jagp_2018_12_002 crossref_primary_10_1007_s11606_020_06329_5 crossref_primary_10_1159_000517285 crossref_primary_10_2147_RMHP_S402025 crossref_primary_10_1016_j_clnu_2019_11_003 crossref_primary_10_1038_s43856_025_00961_0 crossref_primary_10_5009_gnl250010 crossref_primary_10_3390_nu17101685 crossref_primary_10_11124_JBISRIR_2017_004003 crossref_primary_10_1016_j_jpainsymman_2016_01_006 crossref_primary_10_3390_diseases13050137 crossref_primary_10_1111_opn_12591 crossref_primary_10_1016_j_arbres_2021_08_023 crossref_primary_10_1016_j_ecoenv_2024_116649 crossref_primary_10_1016_j_mad_2016_09_009 crossref_primary_10_1007_s00508_016_1087_5 crossref_primary_10_1016_j_nut_2024_112448 crossref_primary_10_1038_s41598_023_42603_2 crossref_primary_10_3390_jcm10061194 crossref_primary_10_3390_diseases11040129 crossref_primary_10_1186_s12877_020_01748_9 crossref_primary_10_1186_s12883_023_03353_w crossref_primary_10_3389_fnut_2022_838613 crossref_primary_10_1111_cob_12336 crossref_primary_10_3389_fpubh_2023_1217699 crossref_primary_10_1016_j_sapharm_2024_04_003 crossref_primary_10_1016_j_bone_2018_11_002 crossref_primary_10_1177_1545968318805159 crossref_primary_10_1016_j_lansea_2025_100579 crossref_primary_10_1038_s41598_021_85813_2 crossref_primary_10_1016_j_apmr_2019_02_014 crossref_primary_10_1371_journal_pone_0314098 crossref_primary_10_1093_ageing_afaf101 crossref_primary_10_1038_s41591_024_03483_9 crossref_primary_10_1177_0260106018817190 crossref_primary_10_1186_s12916_020_01846_w crossref_primary_10_1371_journal_pone_0322042 crossref_primary_10_1007_s40670_016_0283_2 crossref_primary_10_1080_07317115_2022_2076636 crossref_primary_10_1186_s12877_023_03813_5 crossref_primary_10_1186_s12889_025_24034_y crossref_primary_10_1016_j_arcmed_2023_102869 crossref_primary_10_1111_jgs_15783 crossref_primary_10_1016_j_archger_2020_104135 crossref_primary_10_1155_2022_1591511 crossref_primary_10_1016_j_jamda_2017_03_008 crossref_primary_10_1186_s12877_019_1235_7 crossref_primary_10_1016_j_jamda_2019_11_007 crossref_primary_10_1016_j_jamda_2021_12_039 crossref_primary_10_1097_XCE_0000000000000159 crossref_primary_10_3390_ijms222212112 crossref_primary_10_3390_biomedicines5040062 crossref_primary_10_1002_agm2_12346 crossref_primary_10_1016_j_exger_2020_111103 crossref_primary_10_1080_21548331_2024_2435802 crossref_primary_10_1016_j_mayocp_2016_08_002 crossref_primary_10_1136_bmjph_2024_002474 crossref_primary_10_1016_j_pec_2020_08_025 crossref_primary_10_1080_07317115_2024_2401915 crossref_primary_10_1016_j_arbres_2021_08_002 crossref_primary_10_1016_j_gerinurse_2021_04_001 crossref_primary_10_1093_ageing_afy098 crossref_primary_10_3389_fnut_2024_1522212 crossref_primary_10_1111_jgs_19356 crossref_primary_10_1017_S1041610220003403 crossref_primary_10_1016_j_mayocp_2023_09_021 crossref_primary_10_1016_j_ijmedinf_2024_105703 crossref_primary_10_1016_j_ijnurstu_2022_104303 crossref_primary_10_1093_inthealth_ihae018 crossref_primary_10_1038_s41598_023_49129_7 crossref_primary_10_1001_jamanetworkopen_2022_9817 crossref_primary_10_1002_nop2_1570 crossref_primary_10_1093_humrep_dez259 crossref_primary_10_1177_08445621211009405 crossref_primary_10_3390_ijms25158238 crossref_primary_10_5334_gh_1188 crossref_primary_10_1016_j_arr_2017_05_003 crossref_primary_10_1111_acel_13080 crossref_primary_10_1200_EDBK_391516 crossref_primary_10_1371_journal_pone_0301763 crossref_primary_10_1016_j_archger_2023_104959 crossref_primary_10_1038_s43587_025_00812_6 crossref_primary_10_1097_MD_0000000000033389 crossref_primary_10_1186_s12877_020_01965_2 crossref_primary_10_1177_104012371602800307 crossref_primary_10_1186_s12905_023_02319_x crossref_primary_10_3389_fnut_2022_910481 crossref_primary_10_1007_s11136_021_02821_5 crossref_primary_10_1016_j_heliyon_2025_e43510 crossref_primary_10_1038_s43587_022_00243_7 crossref_primary_10_3233_JAD_230809 crossref_primary_10_1080_17474124_2021_1836959 crossref_primary_10_1097_GME_0000000000001712 crossref_primary_10_3390_buildings14061827 crossref_primary_10_1113_JP270543 crossref_primary_10_1186_s12955_019_1245_3 crossref_primary_10_15256_joc_2016_6_72 crossref_primary_10_3389_fnins_2021_749305 crossref_primary_10_1016_j_jad_2022_09_084 crossref_primary_10_1111_eci_12498 crossref_primary_10_1016_j_ddmod_2017_07_005 crossref_primary_10_2196_41768 crossref_primary_10_1038_s41586_019_1365_2 crossref_primary_10_1089_tmj_2021_0331 crossref_primary_10_1177_0018720820964085 crossref_primary_10_1016_j_jamda_2017_02_010 crossref_primary_10_1016_j_healthpol_2025_105414 crossref_primary_10_3389_fmed_2022_896451 crossref_primary_10_1097_MCO_0000000000000330 crossref_primary_10_3390_s20174954 crossref_primary_10_1186_s12955_021_01685_0 crossref_primary_10_3390_ijerph19106092 crossref_primary_10_1093_ageing_afab061 crossref_primary_10_1186_s12877_023_04531_8 crossref_primary_10_1016_j_ophtha_2018_10_012 crossref_primary_10_1038_s41598_023_41628_x crossref_primary_10_1016_j_earlhumdev_2020_105214 crossref_primary_10_1111_1475_6773_14073 crossref_primary_10_1590_1413_81232018241_04952017 crossref_primary_10_1186_s12877_020_01734_1 crossref_primary_10_1093_intqhc_mzaa022 crossref_primary_10_1111_jgs_16672 crossref_primary_10_1186_s12877_022_03451_3 crossref_primary_10_1186_s12875_021_01568_9 crossref_primary_10_2196_35738 crossref_primary_10_3390_ijerph20136301 crossref_primary_10_1016_j_neurobiolaging_2023_09_003 crossref_primary_10_1007_s11357_020_00314_w crossref_primary_10_1016_j_healthpol_2018_03_003 crossref_primary_10_1016_j_arr_2023_101860 crossref_primary_10_7759_cureus_52148 crossref_primary_10_1016_j_jacc_2020_03_028 crossref_primary_10_1136_bjsports_2024_108955 crossref_primary_10_1371_journal_pone_0220368 crossref_primary_10_1016_j_maturitas_2018_11_011 crossref_primary_10_1186_s12863_016_0461_7 crossref_primary_10_1038_s41598_022_18525_w crossref_primary_10_1177_26335565221150124 crossref_primary_10_1159_000513930 crossref_primary_10_1097_JCMA_0000000000001229 crossref_primary_10_1158_0008_5472_CAN_22_1336 crossref_primary_10_1038_s41467_025_58819_x crossref_primary_10_1016_j_archger_2023_105134 crossref_primary_10_1016_j_archger_2018_10_003 crossref_primary_10_1007_s00439_019_01988_9 crossref_primary_10_1111_jgs_16558 crossref_primary_10_2147_TCRM_S291458 crossref_primary_10_1016_j_jgo_2025_102318 crossref_primary_10_1016_j_ejim_2017_05_016 crossref_primary_10_1089_tmr_2022_0035 crossref_primary_10_1093_gerona_glae122 crossref_primary_10_1016_j_pec_2025_109305 |
| ContentType | Journal Article |
| Copyright | Published by Elsevier Inc. |
| Copyright_xml | – notice: Published by Elsevier Inc. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.jamda.2015.03.013 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1538-9375 |
| EndPage | 647 |
| ExternalDocumentID | 25958334 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: Intramural NIH HHS grantid: Z01 AG000015 |
| GroupedDBID | --- --K .1- .FO 0R~ 1B1 1P~ 4.4 457 4CK 5GY 5VS AAEDT AAEDW AALRI AAQFI AAQQT AAWTL AAXUO AAYEP ABFRF ABJNI ABLJU ABMAC ACGFS ADBBV ADBIZ AEFWE AENEX AEVXI AFCTW AFRHN AFTJW AGCQF AHRYX AIGII AITUG AJUYK ALMA_UNASSIGNED_HOLDINGS AMRAJ BELOY CGR CS3 CUY CVF DU5 EBS ECM EFJIC EFKBS EIF EJD EO8 F5P FDB G-Q IHE J1W KOM M41 NPM NQ- O9- OD~ OO0 OVD RIG ROL RPZ SEL SES TEORI UNMZH XH2 Z5R ZFV 7X8 |
| ID | FETCH-LOGICAL-c702t-25c7862ea8bbf57b9eaa51dd5f6bf56463226ba511e927816fb5e9f64722a0ca2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 368 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000358423400004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Wed Oct 01 13:39:43 EDT 2025 Mon Jul 21 05:57:27 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | aging multiple morbidities chronic disease Multimorbidity |
| Language | English |
| License | Published by Elsevier Inc. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c702t-25c7862ea8bbf57b9eaa51dd5f6bf56463226ba511e927816fb5e9f64722a0ca2 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/5125299 |
| PMID | 25958334 |
| PQID | 1699495996 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1699495996 pubmed_primary_25958334 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-08-01 |
| PublicationDateYYYYMMDD | 2015-08-01 |
| PublicationDate_xml | – month: 08 year: 2015 text: 2015-08-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American Medical Directors Association |
| PublicationTitleAlternate | J Am Med Dir Assoc |
| PublicationYear | 2015 |
| SSID | ssj0020196 |
| Score | 2.5772514 |
| SecondaryResourceType | review_article |
| Snippet | Aging is characterized by rising susceptibility to development of multiple chronic diseases and, therefore, represents the major risk factor for... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 640 |
| SubjectTerms | Aged Aging - physiology Biomedical Research Chronic Disease Comorbidity Humans Risk Factors |
| Title | Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25958334 https://www.proquest.com/docview/1699495996 |
| Volume | 16 |
| WOSCitedRecordID | wos000358423400004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7qfBDE-2XeiODjiiZL0tYXGeLUB8ceJuxt5ApT1852-vvNSVt9EgRfShtSKMnpyZecc74PoQtjDUsMF1EiiYqYITpKtGORdIxZ0jWCMxfEJuLBIBmP02F94FbWaZWNTwyO2uQazsgviUhTD-Y9PL-Zv0egGgXR1VpCYxm1uh7KgFXH4-8oAgXul4ZpKOR0vciZAbIhwgOzKWga_IYrw_rS3_zvl22hjRpZ4l5lCttoyWY7aL06lsNVtdEuKnogSoRlZnAovZ3lhZoaj8SvsXd3eCTL17KDh8U0LwLVaid07QPLAWhmYw9x8WPDMGHwvQ38B7X_DH1rotE33OT07aHn_t3o9iGqZRciHV_RRUS5jv0-x8pEKcdjlVopOTGGO-GfBRPeBwjlm4hNaZwQ4RS3qQMeeiqvtKT7aCXLM3uIMAAKkVhqKCAXbZTzd1b7hZNzJZlro_NmSCferCFWITObf5STn0Fto4NqXibzin9j4ndsUCvGjv7w9jFag-muUvZOUMv5n9qeolX9uZiWxVmwF38dDJ--AJKeziw |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Aging+and+Multimorbidity%3A+New+Tasks%2C+Priorities%2C+and+Frontiers+for+Integrated+Gerontological+and+Clinical+Research&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.au=Fabbri%2C+Elisa&rft.au=Zoli%2C+Marco&rft.au=Gonzalez-Freire%2C+Marta&rft.au=Salive%2C+Marcel+E&rft.date=2015-08-01&rft.eissn=1538-9375&rft.volume=16&rft.issue=8&rft.spage=640&rft.epage=647&rft_id=info:doi/10.1016%2Fj.jamda.2015.03.013&rft.externalDBID=NO_FULL_TEXT |