An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer

Charles Perou and colleagues apply a panel of 52 published gene expression signatures of human breast tumors to expression data from The Cancer Genome Project to identify new proliferation drivers. They find genomic regions that are uniquely amplified in highly proliferative luminal breast tumors, i...

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Bibliographic Details
Published in:	Nature genetics Vol. 46; no. 10; pp. 1051 - 1059
Main Authors:	Gatza, Michael L, Silva, Grace O, Parker, Joel S, Fan, Cheng, Perou, Charles M
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2014 Nature Publishing Group
Subjects:	38/39 38/61 38/89 631/208/212 Agriculture analysis Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Research Carcinogenesis Cell Line, Tumor Cell Proliferation Cluster Analysis Deoxyribonucleic acid Development and progression DNA DNA Copy Number Variations Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Function Genes, Essential - genetics Genetic aspects Genetic engineering Genetic Predisposition to Disease - genetics Genetic research Genomes Genomics Genomics - methods Human Genetics Humans Medical research Multivariate Analysis Oligonucleotide Array Sequence Analysis - statistics & numerical data Prognosis Proportional Hazards Models RNA Interference Rodents Signal Transduction - genetics Studies Survival Analysis Tumorigenesis Tumors Variance analysis
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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