Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

Purpose. To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Meth...

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Published in:Journal of ophthalmology Vol. 2018; no. 2018; pp. 1 - 7
Main Authors: Jung, Camille, Cohen, Salomon Yves, Souied, Eric H., Pedinielli, Alexandre, Bruyere, Elsa, Semoun, Oudy, Astroz, Polina, Butori, Pauline, Amoroso, Francesca, Oubraham, Hassiba, Miere, Alexandra, Addou-Regnard, Manar
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects:
Age
Angiography
Care and treatment
Diabetic retinopathy
Image processing
Macular degeneration
Medical equipment and supplies industry
Medical imaging
Medical research
Medical test kit industry
Medicine, Experimental
Morphology
Neovascularization
Pathogenesis
Patients
Public software
Tomography
Vascular endothelial growth factor
France
United States
California
United States > US
ISSN:2090-004X, 2090-0058
Online Access:Get full text
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Summary:Purpose. To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naïve and treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods. Consecutive patients with neovascular AMD underwent multimodal imaging, including OCTA (AngioPlex, CIRRUS HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, OH) at baseline and at three monthly follow-up visits. Treatment-naive AMD patients undergoing anti-VEGF loading phase were included in group A, while treated patients were included in group B. Qualitative and quantitative OCTA analyses were performed on outer retina to choriocapillaris (ORCC) slab. CNV size was measured using a free image analysis software (ImageJ, open-source imaging processing software, 2.0.0). Results. Twenty-five eyes of 25 patients were enrolled in our study (mean age 78.32 ± 6.8 years): 13 treatment-naïve eyes in group A and 12 treated eyes in group B. While qualitative analysis revealed no significant differences from baseline to follow-up in the two groups, quantitative analysis showed in group A a significant decrease in lesion area (P=0.023); in group B, no significant change in the lesion area was observed during anti-VEGF therapy (P=0.93). Conclusion. Treatment-naïve and treated eyes with CNV secondary to neovascular AMD respond differently to anti-VEGF therapy. This should be taken into account when using OCTA for CNV follow-up or planning therapeutic strategies.
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Academic Editor: Talisa E. de Carlo
ISSN:2090-004X
2090-0058
DOI:10.1155/2018/3751702