Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with...

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Bibliographic Details
Published in:Neural plasticity Vol. 2017; no. 2017; pp. 1 - 18
Main Authors: Cui, R., Radziwoń-Zaleska, Maria, Nowak, Gabriel, Wlaź, Piotr, Doboszewska, Urszula, Młyniec, Katarzyna
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects:
Animals
Antidepressants
Biogenic Monoamines - metabolism
Cross-Sectional Studies
Depressive Disorder - drug therapy
Depressive Disorder - metabolism
Dietary Supplements
Drugs
Enzymes
Humans
Hypotheses
Mental depression
Neuronal Plasticity - physiology
Neurons
Neuroplasticity
Pathophysiology
Review
Serotonin
Studies
Women
Zinc - administration & dosage
Zinc - metabolism
ISSN:2090-5904, 1687-5443
Online Access:Get full text
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Summary:Preclinical and clinical studies have demonstrated that zinc possesses antidepressant properties and that it may augment the therapy with conventional, that is, monoamine-based, antidepressants. In this review we aim to discuss the role of zinc in the pathophysiology and treatment of depression with regard to the monoamine hypothesis of the disease. Particular attention will be paid to the recently described zinc-sensing GPR39 receptor as well as aspects of zinc deficiency. Furthermore, an attempt will be made to give a possible explanation of the mechanisms by which zinc interacts with the monoamine system in the context of depression and neural plasticity.
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Academic Editor: Aijun Li
ISSN:2090-5904
1687-5443
DOI:10.1155/2017/3682752