Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

Background Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria infection (CHMI) in clinical trials. Initial CHMI studies showed significantly higher durable protection against homologous than heterologous st...

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Veröffentlicht in:	Genome medicine Jg. 12; H. 1; S. 6 - 17
Hauptverfasser:	Moser, Kara A., Drábek, Elliott F., Dwivedi, Ankit, Stucke, Emily M., Crabtree, Jonathan, Dara, Antoine, Shah, Zalak, Adams, Matthew, Li, Tao, Rodrigues, Priscila T., Koren, Sergey, Phillippy, Adam M., Munro, James B., Ouattara, Amed, Sparklin, Benjamin C., Dunning Hotopp, Julie C., Lyke, Kirsten E., Sadzewicz, Lisa, Tallon, Luke J., Spring, Michele D., Jongsakul, Krisada, Lon, Chanthap, Saunders, David L., Ferreira, Marcelo U., Nyunt, Myaing M., Laufer, Miriam K., Travassos, Mark A., Sauerwein, Robert W., Takala-Harrison, Shannon, Fraser, Claire M., Sim, B. Kim Lee, Hoffman, Stephen L., Plowe, Christopher V., Silva, Joana C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 08.01.2020 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Analysis Antigenic determinants Antigens Artemisinin Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell culture Clinical isolates Clinical trials Clinical Trials as Topic - statistics & numerical data Cloning Deoxyribonucleic acid DNA DNA binding proteins DNA sequencing Epitopes Erythrocytes Gene expression Genetic aspects Genetic engineering Genome assembly Genome, Protozoan Genomes Genomics Health aspects Human Genetics Humans Immunogenicity Immunogenicity, Vaccine Immunology Infection Infections Lymphocytes T Malaria Malaria Vaccines - genetics Malaria Vaccines - immunology Medical research Medicine/Public Health Metabolomics Mortality Nucleotide sequence P. falciparum Parasites PfSPZ vaccine Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Polymorphism, Genetic Product development Single-nucleotide polymorphism Strains (organisms) Structure (Literature) Systems Biology T cells Transcription factors Vaccine efficacy Vaccines Whole genome sequencing Whole-sporozoite vaccine South America Cambodia Southeast Asia Brazil Malawi PfSPZ vaccine Genome assembly Malaria Whole-sporozoite vaccine P. falciparum
ISSN:	1756-994X, 1756-994X
Online-Zugang:	Volltext
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