Role of cholesterol in the development and progression of breast cancer

Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important...

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Bibliographic Details
Published in:The American journal of pathology Vol. 178; no. 1; p. 402
Main Authors: Llaverias, Gemma, Danilo, Christiane, Mercier, Isabelle, Daumer, Kristin, Capozza, Franco, Williams, Terence M, Sotgia, Federica, Lisanti, Michael P, Frank, Philippe G
Format: Journal Article
Language:English
Published: United States 01.01.2011
Subjects:
Animals
Breast Neoplasms - blood
Breast Neoplasms - etiology
Breast Neoplasms - pathology
Cell Transformation, Neoplastic
Cholesterol - administration & dosage
Cholesterol - adverse effects
Cholesterol - blood
Diet - adverse effects
Female
Lung Neoplasms - secondary
Mammary Neoplasms, Experimental - blood
Mammary Neoplasms, Experimental - etiology
Mammary Neoplasms, Experimental - pathology
Mice
Mice, Transgenic
Protein Biosynthesis
ISSN:1525-2191, 1525-2191
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Summary:Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important factors involved in breast cancer initiation and progression. The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. The results suggest that cholesterol accelerates and enhances tumor formation. In addition, tumors were more aggressive, and tumor angiogenesis was enhanced. Metabolism of cholesterol was also examined in this mouse model. It was observed that plasma cholesterol levels were reduced during tumor development but not prior to its initiation. These data provide new evidence for an increased utilization of cholesterol by tumors and for its role in tumor formation. Taken together, these results imply that an increase in plasma cholesterol levels accelerates the development of tumors and exacerbates their aggressiveness.
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ISSN:1525-2191
1525-2191
DOI:10.1016/j.ajpath.2010.11.005