Role of cholesterol in the development and progression of breast cancer
Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important...
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| Vydané v: | The American journal of pathology Ročník 178; číslo 1; s. 402 |
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| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
01.01.2011
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| ISSN: | 1525-2191, 1525-2191 |
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| Abstract | Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important factors involved in breast cancer initiation and progression. The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. The results suggest that cholesterol accelerates and enhances tumor formation. In addition, tumors were more aggressive, and tumor angiogenesis was enhanced. Metabolism of cholesterol was also examined in this mouse model. It was observed that plasma cholesterol levels were reduced during tumor development but not prior to its initiation. These data provide new evidence for an increased utilization of cholesterol by tumors and for its role in tumor formation. Taken together, these results imply that an increase in plasma cholesterol levels accelerates the development of tumors and exacerbates their aggressiveness. |
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| AbstractList | Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important factors involved in breast cancer initiation and progression. The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. The results suggest that cholesterol accelerates and enhances tumor formation. In addition, tumors were more aggressive, and tumor angiogenesis was enhanced. Metabolism of cholesterol was also examined in this mouse model. It was observed that plasma cholesterol levels were reduced during tumor development but not prior to its initiation. These data provide new evidence for an increased utilization of cholesterol by tumors and for its role in tumor formation. Taken together, these results imply that an increase in plasma cholesterol levels accelerates the development of tumors and exacerbates their aggressiveness. Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important factors involved in breast cancer initiation and progression. The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. The results suggest that cholesterol accelerates and enhances tumor formation. In addition, tumors were more aggressive, and tumor angiogenesis was enhanced. Metabolism of cholesterol was also examined in this mouse model. It was observed that plasma cholesterol levels were reduced during tumor development but not prior to its initiation. These data provide new evidence for an increased utilization of cholesterol by tumors and for its role in tumor formation. Taken together, these results imply that an increase in plasma cholesterol levels accelerates the development of tumors and exacerbates their aggressiveness.Diet and obesity are important risk factors for cancer development. Many studies have suggested an important role for several dietary nutrients in the progression and development of breast cancer. However, few studies have specifically addressed the role of components of a Western diet as important factors involved in breast cancer initiation and progression. The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. The results suggest that cholesterol accelerates and enhances tumor formation. In addition, tumors were more aggressive, and tumor angiogenesis was enhanced. Metabolism of cholesterol was also examined in this mouse model. It was observed that plasma cholesterol levels were reduced during tumor development but not prior to its initiation. These data provide new evidence for an increased utilization of cholesterol by tumors and for its role in tumor formation. Taken together, these results imply that an increase in plasma cholesterol levels accelerates the development of tumors and exacerbates their aggressiveness. |
| Author | Capozza, Franco Llaverias, Gemma Williams, Terence M Frank, Philippe G Sotgia, Federica Danilo, Christiane Mercier, Isabelle Lisanti, Michael P Daumer, Kristin |
| Author_xml | – sequence: 1 givenname: Gemma surname: Llaverias fullname: Llaverias, Gemma organization: Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA – sequence: 2 givenname: Christiane surname: Danilo fullname: Danilo, Christiane – sequence: 3 givenname: Isabelle surname: Mercier fullname: Mercier, Isabelle – sequence: 4 givenname: Kristin surname: Daumer fullname: Daumer, Kristin – sequence: 5 givenname: Franco surname: Capozza fullname: Capozza, Franco – sequence: 6 givenname: Terence M surname: Williams fullname: Williams, Terence M – sequence: 7 givenname: Federica surname: Sotgia fullname: Sotgia, Federica – sequence: 8 givenname: Michael P surname: Lisanti fullname: Lisanti, Michael P – sequence: 9 givenname: Philippe G surname: Frank fullname: Frank, Philippe G |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21224077$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. |
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| SubjectTerms | Animals Breast Neoplasms - blood Breast Neoplasms - etiology Breast Neoplasms - pathology Cell Transformation, Neoplastic Cholesterol - administration & dosage Cholesterol - adverse effects Cholesterol - blood Diet - adverse effects Female Lung Neoplasms - secondary Mammary Neoplasms, Experimental - blood Mammary Neoplasms, Experimental - etiology Mammary Neoplasms, Experimental - pathology Mice Mice, Transgenic Protein Biosynthesis |
| Title | Role of cholesterol in the development and progression of breast cancer |
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