Anthrax Lethal Toxin Impairs IL-8 Expression in Epithelial Cells through Inhibition of Histone H3 Modification

Lethal toxin (LT) is a critical virulence factor of Bacillus anthracis, the etiological agent of anthrax, whose pulmonary form is fatal in the absence of treatment. Inflammatory response is a key process of host defense against invading pathogens. We report here that intranasal instillation of a B....

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Bibliographic Details
Published in:	PLoS pathogens Vol. 5; no. 4; p. e1000359
Main Authors:	Raymond, Benoit, Batsche, Eric, Boutillon, Florence, Wu, Yong-Zheng, Leduc, Dominique, Balloy, Viviane, Raoust, Eloïse, Muchardt, Christian, Goossens, Pierre L., Touqui, Lhousseine
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.04.2009 Public Library of Science (PLoS)
Subjects:	Animals Anthrax Antigens, Bacterial Antigens, Bacterial - physiology Antigens, Bacterial - toxicity Bacillus anthracis Bacterial Toxins Bacterial Toxins - toxicity Bacteriology Cell Biology/Leukocyte Signaling and Gene Expression Chromatin Chromatin - metabolism Cytokines Cytokines - genetics Cytokines - metabolism Development and progression Epigenetics Extracellular Signal-Regulated MAP Kinases Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Gene Expression - drug effects Genetic aspects Histones Histones - metabolism Humans Immunology/Cellular Microbiology and Pathogenesis Immunology/Innate Immunity Infections Infectious Diseases/Bacterial Infections Infectious Diseases/Respiratory Infections Interleukin-8 Interleukin-8 - genetics Interleukin-8 - metabolism JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases - metabolism Life Sciences Lung Lung - metabolism Mice Mice, Inbred C57BL Microbiology and Parasitology Molecular Biology/Histone Modification Mortality NF-kappa B NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Physiological aspects Pneumonia Promoter Regions, Genetic Recruitment Respiratory Mucosa Respiratory Mucosa - metabolism France
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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