The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking individual or multiple enzymes remain fully invasive, su...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 10; no. 10; p. e1004413
Main Authors:	Bertuzzi, Margherita, Schrettl, Markus, Alcazar-Fuoli, Laura, Cairns, Timothy C., Muñoz, Alberto, Walker, Louise A., Herbst, Susanne, Safari, Maryam, Cheverton, Angela M., Chen, Dan, Liu, Hong, Saijo, Shinobu, Fedorova, Natalie D., Armstrong-James, Darius, Munro, Carol A., Read, Nick D., Filler, Scott G., Espeso, Eduardo A., Nierman, William C., Haas, Hubertus, Bignell, Elaine M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2014 Public Library of Science (PLoS)
Subjects:	Animals Aspergillosis Aspergillus fumigatus - metabolism Biology and Life Sciences Cell culture Colleges & universities Composting Enzymes Epithelial Cells - microbiology Fungal Proteins - metabolism Gene expression Genetic aspects Health aspects Host-parasite relationships Hydrogen-Ion Concentration Infections Mice Mortality Pulmonary Aspergillosis - microbiology Transcription factors Transcription Factors - metabolism Transplants & implants
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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