Predicting Surgery Targets in Temporal Lobe Epilepsy through Structural Connectome Based Simulations

Temporal lobe epilepsy (TLE) is a prevalent neurological disorder resulting in disruptive seizures. In the case of drug resistant epilepsy resective surgery is often considered. This is a procedure hampered by unpredictable success rates, with many patients continuing to have seizures even after sur...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 11; no. 12; p. e1004642
Main Authors:	Hutchings, Frances, Han, Cheol E., Keller, Simon S., Weber, Bernd, Taylor, Peter N., Kaiser, Marcus
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.12.2015 Public Library of Science (PLoS)
Subjects:	Adult Aged Care and treatment Computer Simulation Connectome - methods Councils Diffusion Tensor Imaging - methods Epilepsy Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - surgery Excision (Surgery) Female Hippocampus - pathology Hippocampus - surgery Humans Male Methods Middle Aged Models, Anatomic Models, Neurological Monitoring, Intraoperative - methods Neurophysiological Monitoring - methods NMR Nuclear magnetic resonance Patient outcomes Patient-Specific Modeling Patients Preoperative Care - methods Public access Standard scores Success Surgery Surgery, Computer-Assisted - methods Temporal lobe epilepsy Treatment Outcome
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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