Gut microbiota and its metabolites in depression: from pathogenesis to treatment

Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that compositional and functional (e.g., metabolite) changes in gut microbiota, known as dysbiosis, are associated with the onset and progression of depress...

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Bibliographic Details
Published in:EBioMedicine Vol. 90; p. 104527
Main Authors: Liu, Lanxiang, Wang, Haiyang, Chen, Xueyi, Zhang, Yangdong, Zhang, Hanping, Xie, Peng
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.04.2023
Elsevier
Subjects:
Advanced Basic Science
Depression
Depression - etiology
Depression - therapy
Depressive Disorder, Major - complications
Depressive Disorder, Major - therapy
Dysbiosis - therapy
Fecal Microbiota Transplantation
Gastrointestinal Microbiome
Gut microbiota
Humans
Internal Medicine
Metabolites
Microbial-targeted therapeutics
Pathogenesis
Probiotics - therapeutic use
Review
Gut microbiota
Depression
Metabolites
Microbial-targeted therapeutics
Pathogenesis
ISSN:2352-3964, 2352-3964
Online Access:Get full text
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Summary:Major depressive disorder is one of the most disabling mental disorders worldwide. Increasing preclinical and clinical studies have highlighted that compositional and functional (e.g., metabolite) changes in gut microbiota, known as dysbiosis, are associated with the onset and progression of depression via regulating the gut-brain axis. However, the gut microbiota and their metabolites present a double-edged sword in depression. Dysbiosis is involved in the pathogenesis of depression while, at the same time, offering a novel therapeutic target. In this review, we describe the association between dysbiosis and depression, drug–microbiota interactions in antidepressant treatment, and the potential health benefits of microbial-targeted therapeutics in depression, including dietary interventions, fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and postbiotics. With the emergence of microbial research, we describe a new direction for future research and clinical treatment of depression.
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These authors contributed equally to this work.
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2023.104527