Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to Chronic Exposure

L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striat...

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Vydáno v:	PloS one Ročník 3; číslo 2; s. e1589
Hlavní autoři:	Scholz, Birger, Svensson, Marcus, Alm, Henrik, Sköld, Karl, Fälth, Maria, Kultima, Kim, Guigoni, Céline, Doudnikoff, Evelyne, Li, Qin, Crossman, Alan R., Bezard, Erwan, Andrén, Per E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 13.02.2008 Public Library of Science (PLoS)
Témata:	Analysis Animals Bayesian analysis Bioinformatics Chromatography Chronic exposure Corpus Striatum - chemistry Dihydroxyphenylalanine Disease Models, Animal Dopa Dopamine Dyskinesia Dyskinesia, Drug-Induced - metabolism Electrophoresis, Gel, Two-Dimensional Experiments Exposure FARMACI Fourier transforms Gel electrophoresis Gene expression Immunoglobulins L-dopa Levodopa Levodopa - administration & dosage Levodopa - adverse effects Macaca Mass Spectrometry Mass spectroscopy Movement disorders MPTP NATURAL SCIENCES NATURVETENSKAP Neostriatum Neurodegenerative diseases Neuroscience/Neurobiology of Disease and Regeneration Neurosciences Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson's disease Parkinsons disease Peptides Pharmaceuticals PHARMACY Phenols (Class of compounds) Post-translation Post-translational modifications Priming Protein Processing, Post-Translational Proteins Proteomics - methods Rats Resveratrol Rodents Scientific imaging Time series
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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