Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to Chronic Exposure
L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striat...
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| Published in: | PloS one Vol. 3; no. 2; p. e1589 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Public Library of Science
13.02.2008
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it. |
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| AbstractList | L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it. L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it.L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to study the proteome in dopamine-depleted striatum with and without subsequent acute and chronic L-dopa treatment using two-dimensional difference in-gel electrophoresis (2D-DIGE) and mass spectrometry. The present data suggest that the dopamine-depleted striatum is so sensitive to de novo L-dopa treatment that the first ever administration alone would be able (i) to induce rapid post-translational modification-based proteomic changes that are specific to this first exposure and (ii), possibly, lead to irreversible protein level changes that would be not further modified by chronic L-dopa treatment. The apparent equivalence between first and chronic L-dopa administration suggests that priming would be the direct consequence of dopamine loss, the first L-dopa administrations only exacerbating the sensitization process but not inducing it. |
| Audience | Academic |
| Author | Crossman, Alan R. Alm, Henrik Fälth, Maria Guigoni, Céline Svensson, Marcus Kultima, Kim Li, Qin Bezard, Erwan Scholz, Birger Doudnikoff, Evelyne Andrén, Per E. Sköld, Karl |
| AuthorAffiliation | University of Massachusetts Medical School, United States of America 4 Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom 1 Department of Pharmaceutical Biosciences, Uppsala Biomedicinska Centrum (BMC), Uppsala University, Uppsala, Sweden 2 Université Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France 3 Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China |
| AuthorAffiliation_xml | – name: 1 Department of Pharmaceutical Biosciences, Uppsala Biomedicinska Centrum (BMC), Uppsala University, Uppsala, Sweden – name: 2 Université Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France – name: University of Massachusetts Medical School, United States of America – name: 3 Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China – name: 4 Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom |
| Author_xml | – sequence: 1 givenname: Birger surname: Scholz fullname: Scholz, Birger – sequence: 2 givenname: Marcus surname: Svensson fullname: Svensson, Marcus – sequence: 3 givenname: Henrik surname: Alm fullname: Alm, Henrik – sequence: 4 givenname: Karl surname: Sköld fullname: Sköld, Karl – sequence: 5 givenname: Maria surname: Fälth fullname: Fälth, Maria – sequence: 6 givenname: Kim surname: Kultima fullname: Kultima, Kim – sequence: 7 givenname: Céline surname: Guigoni fullname: Guigoni, Céline – sequence: 8 givenname: Evelyne surname: Doudnikoff fullname: Doudnikoff, Evelyne – sequence: 9 givenname: Qin surname: Li fullname: Li, Qin – sequence: 10 givenname: Alan R. surname: Crossman fullname: Crossman, Alan R. – sequence: 11 givenname: Erwan surname: Bezard fullname: Bezard, Erwan – sequence: 12 givenname: Per E. surname: Andrén fullname: Andrén, Per E. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18270577$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104848$$DView record from Swedish Publication Index (Uppsala universitet) |
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| Cites_doi | 10.1523/JNEUROSCI.4573-05.2006 10.1186/1471-2105-7-475 10.1093/bioinformatics/bti1022 10.1016/j.nbd.2007.02.001 10.1159/000017326 10.1126/science.2147780 10.1002/ana.20738 10.1073/pnas.90.19.8861 10.1038/nn1632 10.1016/S0969-8051(97)00224-2 10.1093/bioinformatics/bti270 10.2202/1544-6115.1027 10.1126/stke.3332006pe20 10.1101/gad.223302 10.1093/jn/135.6.1531S 10.1016/j.neuroscience.2005.01.007 10.1002/ana.20296 10.1111/j.1460-9568.2005.04190.x 10.1021/pr0503836 10.1016/0024-3205(95)02009-8 10.1152/jn.2001.85.1.117 10.1111/j.1460-9568.2005.04196.x 10.1056/NEJM198804073181402 10.1186/1471-2105-7-191 10.1002/ana.410280412 10.1073/pnas.0506580102 10.1523/JNEUROSCI.1796-06.2006 10.1212/WNL.17.5.427 10.1002/mds.20612 10.1038/nn1040 10.1016/j.neuint.2005.12.002 10.1523/JNEUROSCI.21-17-06853.2001 10.1038/35086062 10.1016/j.tins.2007.03.001 10.1080/10284150600583446 10.1016/j.conb.2005.08.018 10.1016/j.neuro.2005.02.002 10.1523/JNEUROSCI.15-07-05222.1995 10.1515/CCLM.2006.143 10.1523/JNEUROSCI.2582-06.2006 10.1016/S0006-8993(03)03382-1 10.1038/nm875 10.1016/S0166-2236(99)01404-6 10.1016/S0306-4522(98)00440-0 10.1038/19978 10.1046/j.0953-816x.2001.01485.x 10.1016/j.biopsych.2006.06.038 10.1289/ehp.8419 10.1038/nbt0303-255 10.1002/1098-2396(20001201)38:3<363::AID-SYN16>3.0.CO;2-A 10.1523/JNEUROSCI.0599-05.2005 10.1016/j.neuropharm.2004.11.008 10.1038/nrn2055 10.1523/JNEUROSCI.18-14-05301.1998 10.1046/j.0014-2956.2001.02473.x |
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| Copyright | COPYRIGHT 2008 Public Library of Science 2008 Scholz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Scholz et al. 2008 |
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| References | JF Guzowski (ref18) 2005; 15 M Yudkoff (ref30) 2005; 135 C Cepeda (ref29) 2006; 2006 T Kocher (ref56) 2006; 5 SM Hersch (ref54) 1995; 15 P Cohen (ref14) 2001; 268 VA Boundy (ref55) 1993; 43 DJ Brooks (ref34) 1990; 28 P Tsokas (ref19) 2005; 25 E Bezard (ref2) 2001; 2 CR Gerfen (ref5) 1990; 250 GK Smyth (ref58) 2005; 21 GK Smyth (ref57) 2004; 3 A Nadjar (ref11) 2006; 26 AI Levey (ref53) 1993; 90 JS Schneider (ref36) 2003; 990 JD Berke (ref4) 1998; 18 KN Gracy (ref42) 1999; 90 HM Hoehn (ref33) 1967; 17 D Centonze (ref39) 2001; 13 H Alm (ref13) 2006; 114 B Picconi (ref40) 2003; 6 B Picconi (ref41) 2005; 26 I Aubert (ref9) 2007; 61 CD Marsden (ref1) 1982 EM Schuman (ref21) 2006; 26 E Bezard (ref10) 2003; 9 AM Brown (ref22) 2005; 22 HS Waagepetersen (ref43) 1998; 20 A Nadjar (ref31) 2007 PJ Hallett (ref52) 2005; 48 S Zoccolella (ref48) 2006; 44 D van Rossum (ref17) 1999; 22 G Frauscher (ref47) 1995; 57 J Brotchie (ref3) 2005; 20 A Subramanian (ref15) 2005; 102 I Aubert (ref8) 2005; 57 JND Kerr (ref37) 2001; 85 K Kultima (ref6) 2006; 7 VA Derkach (ref25) 2007; 8 D Guilloteau (ref50) 1998; 25 M Day (ref26) 2006; 9 B Stephens (ref27) 2005; 132 A Karpova (ref20) 2006; 26 F Engert (ref38) 1999; 399 A Andrieux (ref16) 2002; 16 C Guigoni (ref12) 2005; 22 C Julien (ref44) 2006; 48 JP Bolam (ref49) 1992 J Ernst (ref7) 2005; 21 P Samadi (ref45) 2006; 59 E Bezard (ref32) 2001; 21 A Siniscalchi (ref46) 2006; 9 J Ernst (ref60) 2006; 7 SJ Kish (ref35) 1988; 318 I Lönnstedt (ref59) 2002; 12 P Calabresi (ref24) 2007; 30 M Mann (ref23) 2003; 21 C Guigoni (ref28) 2007; 26 E Bezard (ref51) 2000; 38 |
| References_xml | – volume: 26 start-page: 4949 year: 2006 ident: ref20 article-title: Involvement of Protein Synthesis and Degradation in Long-Term Potentiation of Schaffer Collateral CA1 Synapses. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.4573-05.2006 – volume: 7 start-page: 475 year: 2006 ident: ref6 article-title: Normalization and expression changes in predefined sets of proteins using 2D gel electrophoresis: a proteomic study of L-DOPA induced dyskinesia in an animal model of Parkinson's disease using DIGE. publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-7-475 – volume: 21 start-page: i159 year: 2005 ident: ref7 article-title: Clustering short time series gene expression data. publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti1022 – volume: 26 start-page: 452 year: 2007 ident: ref28 article-title: Altered D1 dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates. publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2007.02.001 – volume: 20 start-page: 310 year: 1998 ident: ref43 article-title: Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy. publication-title: Dev Neurosci doi: 10.1159/000017326 – volume: 250 start-page: 1429 year: 1990 ident: ref5 article-title: D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. publication-title: Science doi: 10.1126/science.2147780 – volume: 59 start-page: 282 year: 2006 ident: ref45 article-title: Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys. publication-title: Annals of Neurology doi: 10.1002/ana.20738 – volume: 90 start-page: 8861 year: 1993 ident: ref53 article-title: Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.90.19.8861 – volume: 9 start-page: 251 year: 2006 ident: ref26 article-title: Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. publication-title: Nat Neurosci doi: 10.1038/nn1632 – volume: 25 start-page: 331 year: 1998 ident: ref50 article-title: Exploration of the dopamine transporter: in vitro and in vivo characterization of a high-affinity and high-specificity iodinated tropane derivative (E)-N-(3-iodoprop-2-enyl)-2b-carbomethoxy-3b-(4′-methylphenyl) nortropane (PE2I). publication-title: Nucl Med Biol doi: 10.1016/S0969-8051(97)00224-2 – volume: 21 start-page: 2067 year: 2005 ident: ref58 article-title: Use of within-array replicate spots for assessing differential expression in microarray experiments. publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti270 – volume: 3 start-page: Article3 year: 2004 ident: ref57 article-title: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. publication-title: Stat Appl Genet Mol Biol doi: 10.2202/1544-6115.1027 – volume: 2006 start-page: pe20– year: 2006 ident: ref29 article-title: Where Do You Think You Are Going? The NMDA-D1 Receptor Trap. publication-title: Sci STKE doi: 10.1126/stke.3332006pe20 – volume: 16 start-page: 2350 year: 2002 ident: ref16 article-title: The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. publication-title: Genes Dev doi: 10.1101/gad.223302 – volume: 135 start-page: 1531S year: 2005 ident: ref30 article-title: Brain Amino Acid Requirements and Toxicity: The Example of Leucine. publication-title: J Nutr doi: 10.1093/jn/135.6.1531S – volume: 132 start-page: 741 year: 2005 ident: ref27 article-title: Evidence of a breakdown of corticostriatal connections in Parkinson's disease. publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.01.007 – volume: 57 start-page: 17 year: 2005 ident: ref8 article-title: Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. publication-title: Annals of Neurology doi: 10.1002/ana.20296 – volume: 22 start-page: 247 year: 2005 ident: ref22 article-title: Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. publication-title: European Journal of Neuroscience doi: 10.1111/j.1460-9568.2005.04190.x – volume: 5 start-page: 659 year: 2006 ident: ref56 article-title: PhosTShunter: A Fast and Reliable Tool to Detect Phosphorylated Peptides in Liquid Chromatography Fourier Transform Tandem Mass Spectrometry Data Sets. publication-title: J Proteome Res doi: 10.1021/pr0503836 – volume: 57 start-page: 813 year: 1995 ident: ref47 article-title: Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid -- additional mechanisms in homocysteine induced endothelial damage? publication-title: Life Sciences doi: 10.1016/0024-3205(95)02009-8 – volume: 12 start-page: 31 year: 2002 ident: ref59 article-title: Replicated microarray data. publication-title: Stat Sinica – volume: 85 start-page: 117 year: 2001 ident: ref37 article-title: Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro. publication-title: J Neurophysiol doi: 10.1152/jn.2001.85.1.117 – volume: 22 start-page: 283 year: 2005 ident: ref12 article-title: Levodopa-induced dyskinesia in MPTP-treated macaque is not dependent of the extent and pattern of the nigrostrial lesion. publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2005.04196.x – volume: 318 start-page: 876 year: 1988 ident: ref35 article-title: Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. publication-title: N Engl J Med doi: 10.1056/NEJM198804073181402 – start-page: 96 year: 1982 ident: ref1 article-title: Fluctuations of disability in Parkinson's disease-clinical aspects. – volume: 7 start-page: 191 year: 2006 ident: ref60 article-title: STEM: a tool for the analysis of short time series gene expression data. publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-7-191 – volume: 28 start-page: 547 year: 1990 ident: ref34 article-title: Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. publication-title: Ann Neurol doi: 10.1002/ana.410280412 – volume: 102 start-page: 15545 year: 2005 ident: ref15 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0506580102 – volume: 26 start-page: 7143 year: 2006 ident: ref21 article-title: Synaptic Regulation of Translation of Dendritic mRNAs. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1796-06.2006 – volume: 17 start-page: 427 year: 1967 ident: ref33 article-title: Parkinsonism: onset, progression and mortality. publication-title: Neurology doi: 10.1212/WNL.17.5.427 – volume: 20 start-page: 919 year: 2005 ident: ref3 article-title: Nondopaminergic mechanisms in levodopa-induced dyskinesia. publication-title: Movement Disorders doi: 10.1002/mds.20612 – year: 2007 ident: ref31 article-title: Priming for L-dopa-induced dyskinesia in Parkinson's disease: Myth or reality? publication-title: Prog Neurobiol submitted – volume: 6 start-page: 501 year: 2003 ident: ref40 article-title: Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. publication-title: Nat Neurosci doi: 10.1038/nn1040 – volume: 48 start-page: 404 year: 2006 ident: ref44 article-title: Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. publication-title: Neurochemistry International doi: 10.1016/j.neuint.2005.12.002 – volume: 21 start-page: 6853 year: 2001 ident: ref32 article-title: Relationship between the Appearance of Symptoms and the Level of Nigrostriatal Degeneration in a Progressive 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.21-17-06853.2001 – volume: 2 start-page: 577 year: 2001 ident: ref2 article-title: Pathophysiology of levodopa-induced dyskinesia : Potential for new therapies. publication-title: Nature Rev Neurosci doi: 10.1038/35086062 – volume: 30 start-page: 211 year: 2007 ident: ref24 article-title: Dopamine-mediated regulation of corticostriatal synaptic plasticity. publication-title: Trends Neurosci doi: 10.1016/j.tins.2007.03.001 – volume: 9 start-page: 11 year: 2006 ident: ref46 article-title: Role of lifestyle factors on plasma homocysteine levels in Parkison's disease patients treated with levodopa. publication-title: Nutr Neurosci doi: 10.1080/10284150600583446 – volume: 15 start-page: 599 year: 2005 ident: ref18 article-title: Mapping behaviorally relevant neural circuits with immediate-early gene expression. publication-title: Current Opinion in Neurobiology doi: 10.1016/j.conb.2005.08.018 – volume: 26 start-page: 779 year: 2005 ident: ref41 article-title: Pathological Synaptic Plasticity in the Striatum: Implications for Parkinson's Disease. publication-title: NeuroToxicology doi: 10.1016/j.neuro.2005.02.002 – volume: 15 start-page: 5222 year: 1995 ident: ref54 article-title: Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.15-07-05222.1995 – volume: 43 start-page: 666 year: 1993 ident: ref55 article-title: Development of polyclonal anti-D2 dopamine receptor antibodies using sequence-specific peptides. publication-title: Mol Pharmacol – volume: 44 start-page: 863 year: 2006 ident: ref48 article-title: Elevated plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with dyskinesias. publication-title: Clin Chem Lab Med doi: 10.1515/CCLM.2006.143 – volume: 26 start-page: 8653 year: 2006 ident: ref11 article-title: Phenotype of Striatofugal Medium Spiny Neurons in Parkinsonian and Dyskinetic Nonhuman Primates: A Call for a Reappraisal of the Functional Organization of the Basal Ganglia. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2582-06.2006 – volume: 990 start-page: 38 year: 2003 ident: ref36 article-title: Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration of symptoms. publication-title: Brain Res doi: 10.1016/S0006-8993(03)03382-1 – start-page: 1 year: 1992 ident: ref49 article-title: Preparation of central nervous system tissue for light and electron microscopy. – volume: 9 start-page: 762 year: 2003 ident: ref10 article-title: Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. publication-title: Nat Med doi: 10.1038/nm875 – volume: 22 start-page: 290 year: 1999 ident: ref17 article-title: Cytoskeletal dynamics in dendritic spines: direct modulation by glutamate receptors? publication-title: Trends in Neurosciences doi: 10.1016/S0166-2236(99)01404-6 – volume: 90 start-page: 107 year: 1999 ident: ref42 article-title: N-methyl-D-aspartate receptor 1 in the caudate-putamen nucleus: ultrastructural localization and co-expression with sorcin, a 22,000 mol. wt calcium binding protein. publication-title: Neuroscience doi: 10.1016/S0306-4522(98)00440-0 – volume: 399 start-page: 66 year: 1999 ident: ref38 article-title: Dendritic spine changes associated with hippocampal long-term synaptic plasticity. publication-title: Nature doi: 10.1038/19978 – volume: 13 start-page: 1071 year: 2001 ident: ref39 article-title: Dopaminergic control of synaptic plasticity in the dorsal striatum. publication-title: European Journal of Neuroscience doi: 10.1046/j.0953-816x.2001.01485.x – volume: 61 start-page: 836 year: 2007 ident: ref9 article-title: Enhanced Preproenkephalin-B-Derived Opioid Transmission in Striatum and Subthalamic Nucleus Converges Upon Globus Pallidus Internalis in L-3,4-dihydroxyphenylalanine-Induced Dyskinesia. publication-title: Biological Psychiatry doi: 10.1016/j.biopsych.2006.06.038 – volume: 114 start-page: 254 year: 2006 ident: ref13 article-title: Proteomic evaluation of neonatal exposure to 2,2 ,4,4 ,5-pentabromodiphenyl ether. publication-title: Environ Health Perspect doi: 10.1289/ehp.8419 – volume: 21 start-page: 255 year: 2003 ident: ref23 article-title: Proteomic analysis of post-translational modifications. publication-title: Nat Biotech doi: 10.1038/nbt0303-255 – volume: 38 start-page: 363 year: 2000 ident: ref51 article-title: Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice. publication-title: Synapse doi: 10.1002/1098-2396(20001201)38:3<363::AID-SYN16>3.0.CO;2-A – volume: 25 start-page: 5833 year: 2005 ident: ref19 article-title: Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0599-05.2005 – volume: 48 start-page: 503 year: 2005 ident: ref52 article-title: Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned macaque model of Parkinson's disease and dyskinesia. publication-title: Neuropharmacol doi: 10.1016/j.neuropharm.2004.11.008 – volume: 8 start-page: 101 year: 2007 ident: ref25 article-title: Regulatory mechanisms of AMPA receptors in synaptic plasticity. publication-title: Nat Rev Neurosci doi: 10.1038/nrn2055 – volume: 18 start-page: 5301 year: 1998 ident: ref4 article-title: A complex program of striatal gene expression induced by dopaminergic stimulation. publication-title: J Neurosci doi: 10.1523/JNEUROSCI.18-14-05301.1998 – volume: 268 start-page: 5001 year: 2001 ident: ref14 article-title: The role of protein phosphorylation in human health and disease. Delivered on June 30th 2001 at the FEBS Meeting in Lisbon. publication-title: European Journal of Biochemistry doi: 10.1046/j.0014-2956.2001.02473.x |
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| Title | Striatal Proteomic Analysis Suggests that First L-Dopa Dose Equates to Chronic Exposure |
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