Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid t...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 9; no. 6; p. e1003481
Main Authors:	Hollenbaugh, Joseph A., Gee, Peter, Baker, Jonathon, Daly, Michele B., Amie, Sarah M., Tate, Jessica, Kasai, Natsumi, Kanemura, Yuka, Kim, Dong-Hyun, Ward, Brian M., Koyanagi, Yoshio, Kim, Baek
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.06.2013 Public Library of Science (PLoS)
Subjects:	Biology Cell Line DNA viruses Enzymes Female Health aspects Herpesvirus 1, Human - physiology Host-parasite relationships Humans Hydrolases Infections Lymphocytes Male Medicine Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid Cells - virology Pathogenesis Physiological aspects Proteins SAM Domain and HD Domain-Containing Protein 1 Vaccinia virus - physiology Virus Replication - physiology Viruses South Korea
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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