Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens Jg. 9; H. 6; S. e1003481
Hauptverfasser:	Hollenbaugh, Joseph A., Gee, Peter, Baker, Jonathon, Daly, Michele B., Amie, Sarah M., Tate, Jessica, Kasai, Natsumi, Kanemura, Yuka, Kim, Dong-Hyun, Ward, Brian M., Koyanagi, Yoshio, Kim, Baek
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 01.06.2013 Public Library of Science (PLoS)
Schlagworte:	Biology Cell Line DNA viruses Enzymes Female Health aspects Herpesvirus 1, Human - physiology Host-parasite relationships Humans Hydrolases Infections Lymphocytes Male Medicine Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid Cells - virology Pathogenesis Physiological aspects Proteins SAM Domain and HD Domain-Containing Protein 1 Vaccinia virus - physiology Virus Replication - physiology Viruses South Korea
ISSN:	1553-7374, 1553-7366, 1553-7374
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells.
AbstractList	SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells.SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid cells. Since DNA viruses utilize cellular dNTPs, we investigated whether SAMHD1 limits the replication of DNA viruses in non-dividing myeloid target cells. Indeed, two double stranded DNA viruses, vaccinia and herpes simplex virus type 1, are subject to SAMHD1 restriction in non-dividing target cells in a dNTP dependent manner. Using a thymidine kinase deficient strain of vaccinia virus, we demonstrate a greater restriction of viral replication in non-dividing cells expressing SAMHD1. Therefore, this study suggests that SAMHD1 is a potential innate anti-viral player that suppresses the replication of a wide range of DNA viruses, as well as retroviruses, which infect non-dividing myeloid cells. Various viral pathogens such as HIV-1, herpes simplex virus (HSV) and vaccinia virus infect terminally-differentiated/non-dividing macrophages during the course of viral pathogenesis. Unlike dividing cells, non-dividing cells lack chromosomal DNA replication, do not enter the cell cycle, and harbor very low levels of cellular dNTPs, which are substrates of viral DNA polymerases. A series of recent studies revealed that the host protein SAMHD1 is dNTP triphosphohydrolase, which contributes to the poor dNTP abundance in non-dividing myeloid cells, and restricts proviral DNA synthesis of HIV-1 and other lentiviruses in macrophages, dendritic cells, and resting T cells. In this report, we demonstrate that SAMHD1 also controls the replication of large dsDNA viruses: vaccinia virus and HSV-1, in primary human monocyte-derived macrophages. SAMHD1 suppresses the replication of these DNA viruses to an even greater extent in the absence of viral genes that are involved in dNTP metabolism such as thymidine kinase. Therefore, this study supports that dsDNA viruses evolved to express enzymes necessary to increase the levels of dNTPs as a mechanism to overcome the restriction induced by SAMHD1 in myeloid cells.
Audience	Academic
Author	Hollenbaugh, Joseph A. Daly, Michele B. Kanemura, Yuka Kim, Dong-Hyun Ward, Brian M. Koyanagi, Yoshio Kasai, Natsumi Gee, Peter Tate, Jessica Amie, Sarah M. Baker, Jonathon Kim, Baek
AuthorAffiliation	2 Center for Drug Discovery, The Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America 3 Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Japan 4 Department of Pharmacy, Kyung-Hee University, Seoul, South Korea 1 Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America University of Pennsylvania School of Medicine, United States of America
AuthorAffiliation_xml	– name: 3 Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Japan – name: 4 Department of Pharmacy, Kyung-Hee University, Seoul, South Korea – name: 2 Center for Drug Discovery, The Department of Pediatrics, Emory University, Atlanta, Georgia, United States of America – name: University of Pennsylvania School of Medicine, United States of America – name: 1 Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America
Author_xml	– sequence: 1 givenname: Joseph A. surname: Hollenbaugh fullname: Hollenbaugh, Joseph A. – sequence: 2 givenname: Peter surname: Gee fullname: Gee, Peter – sequence: 3 givenname: Jonathon surname: Baker fullname: Baker, Jonathon – sequence: 4 givenname: Michele B. surname: Daly fullname: Daly, Michele B. – sequence: 5 givenname: Sarah M. surname: Amie fullname: Amie, Sarah M. – sequence: 6 givenname: Jessica surname: Tate fullname: Tate, Jessica – sequence: 7 givenname: Natsumi surname: Kasai fullname: Kasai, Natsumi – sequence: 8 givenname: Yuka surname: Kanemura fullname: Kanemura, Yuka – sequence: 9 givenname: Dong-Hyun surname: Kim fullname: Kim, Dong-Hyun – sequence: 10 givenname: Brian M. surname: Ward fullname: Ward, Brian M. – sequence: 11 givenname: Yoshio surname: Koyanagi fullname: Koyanagi, Yoshio – sequence: 12 givenname: Baek surname: Kim fullname: Kim, Baek
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23825958$$D View this record in MEDLINE/PubMed
BookMark	eNqVkl1v0zAYhSM0xD7gHyCIxA1ctNjx9y6QqpbSSluRNuDWcmyneErjYjsT-_c4tJtWhJBQLhw5zzl5fXxOi6POd7YoXkIwhojB9ze-D51qx9utSmMIAMIcPilOICFoxBDDR4_ej4vTGG8AwBBB-qw4rhCviCD8pJgvfEzlXOnkQ3k9uVzMYHllYwpOp1jOVpPymwt9tLF0Xbny3Wjmbp1x3bq8vLOtd6ac2raNz4unjWqjfbFfz4qv849fpovRxedPy-nkYqSpEGmEDTSQEagAAMZoXjPQVARxRrGglouKYI0r1GDNiWJVbVlTqYoLXFvYGMPQWfF657ttfZT7CKKEuGIoHwjCTCx3hPHqRm6D26hwJ71y8veGD2upQnK6tVIhgokGVFlFMbNCMJxjIbamFa-FsNnrw_5vfb2xRtsuBdUemB5-6dx3ufa3ElGBOR2Gebs3CP5Hn2OVGxd1Dkx11vd5biQ4RhjR4WRvduha5dFc1_jsqAdcThABkGIkBsPxX6j8GLtxOhekcXn_QPDuQJCZZH-mtepjlMvrq_9gV4fsq8fRPGRy36wM4B2gg48x2OYBgUAOBb6_PTkUWO4LnGXnf8i0Syo5PwTs2n-LfwHzSPRG
CitedBy_id	crossref_primary_10_1016_j_bbamcr_2018_09_012 crossref_primary_10_1128_AAC_03903_14 crossref_primary_10_1038_s41467_025_56208_y crossref_primary_10_1186_s13578_021_00636_y crossref_primary_10_1016_j_leukres_2016_11_010 crossref_primary_10_1128_mSphere_00448_19 crossref_primary_10_1016_j_chom_2013_09_009 crossref_primary_10_1074_jbc_RA118_004567 crossref_primary_10_1016_j_jbc_2023_104750 crossref_primary_10_3389_fimmu_2022_1007718 crossref_primary_10_1371_journal_pone_0228005 crossref_primary_10_1038_s41577_020_0391_5 crossref_primary_10_3390_ijms24119624 crossref_primary_10_1016_j_tim_2015_08_002 crossref_primary_10_1093_jac_dku276 crossref_primary_10_1093_jac_dkv363 crossref_primary_10_1016_j_cytogfr_2020_03_001 crossref_primary_10_1038_s41467_020_15072_8 crossref_primary_10_1371_journal_pone_0133651 crossref_primary_10_1038_s41467_020_16983_2 crossref_primary_10_1038_s41564_019_0529_z crossref_primary_10_3390_v11100921 crossref_primary_10_1007_s12250_021_00351_5 crossref_primary_10_1002_advs_202407241 crossref_primary_10_1016_j_jbc_2023_104925 crossref_primary_10_1016_j_jbc_2022_101635 crossref_primary_10_1371_journal_pone_0169052 crossref_primary_10_3389_fcimb_2020_00391 crossref_primary_10_1016_j_immuni_2020_06_014 crossref_primary_10_3389_fmicb_2014_00126 crossref_primary_10_1016_j_jmgm_2024_108748 crossref_primary_10_1099_jgv_0_001232 crossref_primary_10_7554_eLife_38867 crossref_primary_10_1007_s00430_020_00684_0 crossref_primary_10_1016_j_dci_2018_05_011 crossref_primary_10_15252_embr_201847528 crossref_primary_10_3389_fimmu_2017_01541 crossref_primary_10_3390_cells8080922 crossref_primary_10_1073_pnas_1412289111 crossref_primary_10_1186_s12977_015_0229_6 crossref_primary_10_1186_s12977_014_0063_2 crossref_primary_10_1128_JVI_01097_19 crossref_primary_10_1128_JVI_02002_13 crossref_primary_10_1371_journal_pone_0089558 crossref_primary_10_1016_j_pep_2016_04_011 crossref_primary_10_3389_fcell_2021_671067 crossref_primary_10_1016_j_virol_2015_08_006 crossref_primary_10_1016_j_virol_2016_05_001 crossref_primary_10_3390_ijms20071695 crossref_primary_10_1074_jbc_M115_677435 crossref_primary_10_1007_s11030_023_10692_w crossref_primary_10_1002_advs_202411988 crossref_primary_10_1016_j_jmb_2013_10_022 crossref_primary_10_1038_s41467_022_34578_x crossref_primary_10_1074_jbc_C113_522326 crossref_primary_10_1073_pnas_1908755116 crossref_primary_10_1189_jlb_4HI0714_338RR crossref_primary_10_3390_ijms20030645 crossref_primary_10_1016_j_antiviral_2023_105689 crossref_primary_10_1038_s41564_019_0557_8 crossref_primary_10_3389_fmolb_2021_724870 crossref_primary_10_1080_15384101_2015_1030558 crossref_primary_10_1074_jbc_RA119_011466 crossref_primary_10_3390_v12040382 crossref_primary_10_1002_prot_25287 crossref_primary_10_1016_j_dci_2014_07_024 crossref_primary_10_1016_j_scib_2019_12_028 crossref_primary_10_1038_emboj_2013_190 crossref_primary_10_1073_pnas_1801213115 crossref_primary_10_1089_ars_2016_6888 crossref_primary_10_1038_s41598_018_22432_4 crossref_primary_10_1182_blood_2013_04_490847 crossref_primary_10_1186_s12985_024_02295_0 crossref_primary_10_1128_JVI_01024_15 crossref_primary_10_3390_v16091412 crossref_primary_10_1038_srep26616 crossref_primary_10_1088_1742_6596_759_1_012026 crossref_primary_10_3390_v13020179 crossref_primary_10_3892_mmr_2015_4332 crossref_primary_10_1002_rmv_1931 crossref_primary_10_1007_s00430_019_00593_x crossref_primary_10_1074_jbc_RA119_010360 crossref_primary_10_2478_jvetres_2021_0056 crossref_primary_10_1128_JVI_01970_20 crossref_primary_10_3390_v13030395 crossref_primary_10_1074_jbc_M114_571091 crossref_primary_10_1107_S1399004714027527 crossref_primary_10_1016_j_cytogfr_2014_08_006 crossref_primary_10_1074_jbc_M114_591958 crossref_primary_10_1371_journal_ppat_1008855 crossref_primary_10_1016_j_jbc_2021_101170 crossref_primary_10_1016_j_jbc_2025_110567 crossref_primary_10_1186_s12985_024_02343_9 crossref_primary_10_1074_jbc_M115_646588 crossref_primary_10_1038_mtm_2016_66 crossref_primary_10_1371_journal_ppat_1004017 crossref_primary_10_1016_j_virol_2015_11_022 crossref_primary_10_1038_s41577_022_00705_4 crossref_primary_10_3389_fonc_2017_00229 crossref_primary_10_1016_j_coviro_2019_11_002 crossref_primary_10_1080_15548627_2020_1846301 crossref_primary_10_1007_s00109_021_02128_5 crossref_primary_10_1128_JVI_00620_21 crossref_primary_10_1128_JVI_01787_17 crossref_primary_10_1016_j_jhep_2019_12_009 crossref_primary_10_1186_1742_4690_11_12 crossref_primary_10_1002_bies_201400079 crossref_primary_10_1042_BST20180348 crossref_primary_10_3389_fphar_2019_01011 crossref_primary_10_1016_j_antiviral_2017_03_019 crossref_primary_10_3389_fimmu_2022_1088690 crossref_primary_10_1073_pnas_1312901110 crossref_primary_10_1074_jbc_M115_663658 crossref_primary_10_1080_08916934_2018_1454912 crossref_primary_10_1089_aid_2013_0119 crossref_primary_10_1128_JVI_00292_18 crossref_primary_10_1016_j_celrep_2024_114471 crossref_primary_10_1016_j_cyto_2020_155025 crossref_primary_10_1016_j_bbrc_2014_07_023 crossref_primary_10_1016_j_jbc_2023_104984 crossref_primary_10_3390_microorganisms8121965 crossref_primary_10_1128_JVI_02291_13 crossref_primary_10_1186_s12977_015_0174_4 crossref_primary_10_1007_s13337_022_00799_3 crossref_primary_10_3389_fimmu_2022_910780 crossref_primary_10_1007_s00018_014_1646_8
Cites_doi	10.1016/0042-6822(87)90468-5 10.1128/JVI.75.16.7528-7542.2001 10.1038/nbt.1500 10.1017/CBO9780511545313.018 10.3109/08820139.2012.750340 10.1007/BF00928361 10.1371/journal.ppat.1002635 10.1080/15257771003729591 10.1371/journal.ppat.1002083 10.1016/j.cub.2012.02.070 10.3390/v3091624 10.1016/0092-8674(81)90346-9 10.1586/erv.11.121 10.1038/nature10623 10.1096/fj.06-7272com 10.1016/j.jviromet.2007.01.017 10.1038/nature10117 10.1128/JVI.02327-06 10.1371/journal.ppat.1002425 10.1074/jbc.M110.178582 10.1128/JVI.01657-12 10.1586/erv.11.79 10.1016/j.virol.2012.10.029 10.1007/BF01310858 10.1016/0042-6822(89)90244-4 10.2174/1874091X00701010033 10.1038/nature10195 10.1038/317813a0 10.1128/JVI.02514-12 10.1038/gt.2012.61 10.1016/j.jsb.2011.03.010 10.1128/JVI.00187-09 10.1038/ni.2236 10.1038/nm.2964 10.1097/COH.0b013e32835fc53e 10.1016/j.bbagrm.2010.01.012 10.1002/jmr.1120 10.1074/jbc.M408573200 10.1074/jbc.C112.374843 10.2222/jsv.58.27 10.1128/JVI.01181-08 10.1016/0042-6822(90)90294-2 10.1128/JVI.05557-11 10.1128/JVI.40.2.456-464.1981 10.1016/j.cellimm.2007.06.005 10.1186/1742-4690-9-105 10.1371/journal.pone.0015615 10.1074/jbc.C111.317628 10.1038/ng.373 10.1371/journal.ppat.0020132 10.1371/journal.ppat.1000984 10.1186/1742-4690-8-55 10.1128/JVI.79.8.4755-4763.2005 10.1016/j.virol.2012.11.010 10.1128/AAC.23.5.676 10.1038/nprot.2011.327 10.1016/S0168-8278(12)60007-5 10.1006/viro.1993.1424 10.1038/sj.cgt.7700549 10.1186/1742-4690-9-87 10.1016/S0188-0128(99)00021-4 10.1099/0022-1317-78-8-1977 10.1074/jbc.M112.443796 10.1016/0092-8674(90)90802-L 10.1111/j.1365-2249.2011.04502.x 10.1074/jbc.M600291200
ContentType	Journal Article
Copyright	COPYRIGHT 2013 Public Library of Science 2013 Hollenbaugh et al 2013 Hollenbaugh et al 2013 Hollenbaugh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hollenbaugh JA, Gee P, Baker J, Daly MB, Amie SM, et al. (2013) Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells. PLoS Pathog 9(6): e1003481. doi:10.1371/journal.ppat.1003481
Copyright_xml	– notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Hollenbaugh et al 2013 Hollenbaugh et al – notice: 2013 Hollenbaugh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Hollenbaugh JA, Gee P, Baker J, Daly MB, Amie SM, et al. (2013) Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells. PLoS Pathog 9(6): e1003481. doi:10.1371/journal.ppat.1003481
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM ISN ISR 7X8 5PM DOA
DOI	10.1371/journal.ppat.1003481
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Canada Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) Open Access: DOAJ - Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: Directory of Open Access Journals (DOAJ) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology Medicine
DocumentTitleAlternate	Regulation of DNA Virus Replication by SAMHD1
EISSN	1553-7374
ExternalDocumentID	1427359511 oai_doaj_org_article_a3545c06aea647e99748255eb628b99e PMC3694861 A350164391 23825958 10_1371_journal_ppat_1003481
Genre	Clinical Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	South Korea
GeographicLocations_xml	– name: South Korea
GrantInformation_xml	– fundername: NIAID NIH HHS grantid: AI077401 – fundername: NIAID NIH HHS grantid: R01 AI049781 – fundername: NIAID NIH HHS grantid: AI099712 – fundername: NIGMS NIH HHS grantid: GM068411 – fundername: NIGMS NIH HHS grantid: R01 GM104198 – fundername: NIAID NIH HHS grantid: AI067391 – fundername: NIAID NIH HHS grantid: R01 AI067391 – fundername: NIAID NIH HHS grantid: R21 AI099712 – fundername: NIAID NIH HHS grantid: AI049781 – fundername: NIAID NIH HHS grantid: R56 AI049781
GroupedDBID	--- 123 29O 2WC 53G 5VS 7X7 88E 8FE 8FH 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS B0M BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD EMK EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HMCUK HYE IAO IHR INH INR ISN ISR ITC KQ8 LK8 M1P M48 M7P MM. O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO QF4 QN7 RNS RPM SV3 TR2 TUS UKHRP WOW ~8M CGR CUY CVF ECM EIF H13 IPNFZ NPM PV9 RIG RZL WOQ 7X8 PUEGO 5PM 3V. AAPBV ABPTK M~E
ID	FETCH-LOGICAL-c699t-4d1d1751a000ddc8b70f253876496e89254c423f4c85a72be7f2a2894be1fdd73
IEDL.DBID	FPL
ISICitedReferencesCount	143
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000321206600065&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1553-7374 1553-7366
IngestDate	Sun Oct 01 00:11:15 EDT 2023 Fri Oct 03 12:52:48 EDT 2025 Tue Nov 04 01:57:39 EST 2025 Fri Sep 05 11:07:15 EDT 2025 Tue Nov 11 10:05:13 EST 2025 Tue Nov 04 17:19:15 EST 2025 Thu Nov 13 14:47:12 EST 2025 Thu Nov 13 15:00:37 EST 2025 Tue Aug 05 11:41:59 EDT 2025 Sat Nov 29 02:23:46 EST 2025 Tue Nov 18 22:28:03 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	6
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c699t-4d1d1751a000ddc8b70f253876496e89254c423f4c85a72be7f2a2894be1fdd73
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Conceived and designed the experiments: B. Kim, B.M. Ward, Y. Koyanagi, D. Kim. Performed the experiments: J.A. Hollenbaugh, P. Gee, M.B. Daly, J. Baker, S.M. Amie, N. Kasai, Y. Kanemura, B.M. Ward, J. Tate. Analyzed the data: J.A. Hollenbaugh, P. Gee, M.B. Daly, J. Baker, S.M. Amie, N. Kasai, Y. Kanemura, B.M. Ward, J. Tate. Contributed reagents/materials/analysis tools: J.A. Hollenbaugh, P. Gee, M.B. Daly, J. Baker, S.M. Amie, N. Kasai, Y. Kanemura, B.M. Ward. Wrote the paper: J.A. Hollenbaugh, P. Gee, B.M. Ward, Y. Koyanagi, B. Kim. The authors have declared that no competing interests exist.
OpenAccessLink	http://dx.doi.org/10.1371/journal.ppat.1003481
PMID	23825958
PQID	1398434367
PQPubID	23479
ParticipantIDs	plos_journals_1427359511 doaj_primary_oai_doaj_org_article_a3545c06aea647e99748255eb628b99e pubmedcentral_primary_oai_pubmedcentral_nih_gov_3694861 proquest_miscellaneous_1398434367 gale_infotracmisc_A350164391 gale_infotracacademiconefile_A350164391 gale_incontextgauss_ISR_A350164391 gale_incontextgauss_ISN_A350164391 pubmed_primary_23825958 crossref_primary_10_1371_journal_ppat_1003481 crossref_citationtrail_10_1371_journal_ppat_1003481
PublicationCentury	2000
PublicationDate	2013-06-01
PublicationDateYYYYMMDD	2013-06-01
PublicationDate_xml	– month: 06 year: 2013 text: 2013-06-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco, USA
PublicationTitle	PLoS pathogens
PublicationTitleAlternate	PLoS Pathog
PublicationYear	2013
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	VK Jamburuthugoda (ref11) 2006; 281 SJ Goebel (ref62) 1990; 179 M Husain (ref65) 2001; 75 K Hrecka (ref5) 2011; 474 TE White (ref24) 2012; 436 BM Ward (ref33) 2005; 79 CR Cotter (ref44) 2011; 85 KJ Laing (ref51) 2012; 167 MW Bahar (ref50) 2011; 175 H Yuwen (ref53) 1993; 195 SR Walsh (ref48) 2011; 10 J Bustos (ref28) 1999; 30 LE Post (ref46) 1981; 24 JG Jacobson (ref32) 1989; 173 H Hofmann (ref34) 2012; 86 I Liashkovich (ref55) 2011; 24 DC Goldstone (ref9) 2011; 480 J Munger (ref3) 2006; 2 M Kummer (ref45) 2007; 81 R Rubenstein (ref31) 1983; 78 HP Huemer (ref58) 2013; 42 M Craveiro (ref1) 2013; 8 J Munger (ref4) 2008; 26 A Bergamaschi (ref16) 2009; 83 DB Gammon (ref42) 2010; 6 DE Hruby (ref41) 1981; 40 HM Baldauf (ref21) 2012; 18 GI Rice (ref23) 2009; 41 HJ Zeh (ref37) 2002; 9 JC Brown (ref63) 2007; 1 JA Zack (ref66) 1990; 61 V Planelles (ref39) 2011; 3 H Lahouassa (ref8) 2012; 13 KH Rubins (ref25) 2011; 6 C Goujon (ref17) 2008; 82 P Eitz Ferrer (ref26) 2011; 7 C St Gelais (ref40) 2011; 8 EL Lousberg (ref47) 2011; 10 BJ Placek (ref54) 2010; 1799 C St Gelais (ref18) 2012; 9 A Berger (ref22) 2011; 7 JA Lopez-Guerrero (ref30) 1997; 78 TL Diamond (ref13) 2004; 279 B Munch-Petersen (ref38) 2010; 29 T Satoh (ref49) 2008; 58 Y Yao (ref57) 2007; 246 DJ Mock (ref64) 2012; 8 B Descours (ref20) 2012; 9 DF Smee (ref43) 1983; 23 I Puigdomenech (ref52) 2012; 87 J Yan (ref56) 2013; 288 PY Ke (ref60) 2007; 21 ref27 RM Buller (ref36) 1985; 317 TW Traut (ref12) 1994; 140 SM Amie (ref15) 2013; 436 S Bobadilla (ref19) 2012; 20 I Salguero (ref61) 2012; 22 RF Smith (ref59) 2007; 142 RD Powell (ref10) 2011; 286 I Domke-Opitz (ref29) 1987; 159 E Bugianesi (ref2) 2012; 56 Suppl 1 B Kim (ref6) 2012; 287 EM Kennedy (ref14) 2010; 285 N Laguette (ref7) 2011; 474 G Berger (ref35) 2011; 6
References_xml	– volume: 159 start-page: 306 year: 1987 ident: ref29 article-title: Role of interferon in persistent infection of macrophages with herpes simplex virus publication-title: Virology doi: 10.1016/0042-6822(87)90468-5 – volume: 75 start-page: 7528 year: 2001 ident: ref65 article-title: Vaccinia virus F13L protein with a conserved phospholipase catalytic motif induces colocalization of the B5R envelope glycoprotein in post-Golgi vesicles publication-title: J Virol doi: 10.1128/JVI.75.16.7528-7542.2001 – volume: 26 start-page: 1179 year: 2008 ident: ref4 article-title: Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy publication-title: Nat Biotechnol doi: 10.1038/nbt.1500 – ident: ref27 doi: 10.1017/CBO9780511545313.018 – volume: 42 start-page: 164 year: 2013 ident: ref58 article-title: Protein kinase C overexpression does not enhance immune-stimulatory surface markers of vaccinia-infected dendritic cells and DC cell lines publication-title: Immunol Investigations doi: 10.3109/08820139.2012.750340 – volume: 140 start-page: 1 year: 1994 ident: ref12 article-title: Physiological concentrations of purines and pyrimidines publication-title: Mol Cell Biochem doi: 10.1007/BF00928361 – volume: 8 start-page: e1002635 year: 2012 ident: ref64 article-title: Leishmania induces survival, proliferation and elevated cellular dNTP levels in human monocytes promoting acceleration of HIV co-infection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1002635 – volume: 29 start-page: 363 year: 2010 ident: ref38 article-title: Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review publication-title: Nucleosides, Nucleotides & Nucleic Acids doi: 10.1080/15257771003729591 – volume: 7 start-page: e1002083 year: 2011 ident: ref26 article-title: Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa publication-title: PLoS Pathogens doi: 10.1371/journal.ppat.1002083 – volume: 22 start-page: 720 year: 2012 ident: ref61 article-title: Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen publication-title: Current Biol : CB doi: 10.1016/j.cub.2012.02.070 – volume: 3 start-page: 1624 year: 2011 ident: ref39 article-title: Restricted access to myeloid cells explained publication-title: Viruses doi: 10.3390/v3091624 – volume: 24 start-page: 555 year: 1981 ident: ref46 article-title: Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters publication-title: Cell doi: 10.1016/0092-8674(81)90346-9 – volume: 10 start-page: 1435 year: 2011 ident: ref47 article-title: Innate immune recognition of poxviral vaccine vectors publication-title: Expert Rev Vaccines doi: 10.1586/erv.11.121 – volume: 480 start-page: 379 year: 2011 ident: ref9 article-title: HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase publication-title: Nature doi: 10.1038/nature10623 – volume: 21 start-page: 1276 year: 2007 ident: ref60 article-title: Hiding human thymidine kinase 1 from APC/C-mediated destruction by thymidine binding publication-title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology doi: 10.1096/fj.06-7272com – volume: 142 start-page: 151 year: 2007 ident: ref59 article-title: Biophysical characterization of vaccinia virus thymidine kinase substrate utilization publication-title: J Virol Methods doi: 10.1016/j.jviromet.2007.01.017 – volume: 474 start-page: 654 year: 2011 ident: ref7 article-title: SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx publication-title: Nature doi: 10.1038/nature10117 – volume: 81 start-page: 6326 year: 2007 ident: ref45 article-title: Herpes simplex virus type 1 induces CD83 degradation in mature dendritic cells with immediate-early kinetics via the cellular proteasome publication-title: J Virol doi: 10.1128/JVI.02327-06 – volume: 7 start-page: e1002425 year: 2011 ident: ref22 article-title: SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection publication-title: PLoS Pathogens doi: 10.1371/journal.ppat.1002425 – volume: 285 start-page: 39380 year: 2010 ident: ref14 article-title: rNTPs as substrate of human immunodeficiency virus type 1 reverse transcriptase in human macrophages publication-title: J Biol Chem doi: 10.1074/jbc.M110.178582 – volume: 86 start-page: 12552 year: 2012 ident: ref34 article-title: The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus publication-title: J Virol doi: 10.1128/JVI.01657-12 – volume: 10 start-page: 1221 year: 2011 ident: ref48 article-title: Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors publication-title: Expert Rev Vaccines doi: 10.1586/erv.11.79 – volume: 436 start-page: 81 year: 2012 ident: ref24 article-title: Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1 publication-title: Virology doi: 10.1016/j.virol.2012.10.029 – volume: 78 start-page: 49 year: 1983 ident: ref31 article-title: Replication of thymidine kinase deficient herpes simplex virus type 1 in neuronal cell culture: infection of the PC 12 cell publication-title: Arch Virology doi: 10.1007/BF01310858 – volume: 173 start-page: 276 year: 1989 ident: ref32 article-title: A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells publication-title: Virology doi: 10.1016/0042-6822(89)90244-4 – volume: 1 start-page: 33 year: 2007 ident: ref63 article-title: High G+C Content of Herpes Simplex Virus DNA: Proposed Role in Protection Against Retrotransposon Insertion publication-title: The open Biochemistry Journal doi: 10.2174/1874091X00701010033 – volume: 474 start-page: 658 year: 2011 ident: ref5 article-title: Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein publication-title: Nature doi: 10.1038/nature10195 – volume: 317 start-page: 813 year: 1985 ident: ref36 article-title: Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype publication-title: Nature doi: 10.1038/317813a0 – volume: 87 start-page: 2846 year: 2012 ident: ref52 article-title: SAMHD1 Restricts HIV-1 Cell-to-Cell Transmission And Limits Immune Detection In Monocyte-Derived Dendritic Cells publication-title: J Virol doi: 10.1128/JVI.02514-12 – volume: 20 start-page: 514 year: 2012 ident: ref19 article-title: Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein publication-title: Gene Ther doi: 10.1038/gt.2012.61 – volume: 175 start-page: 127 year: 2011 ident: ref50 article-title: How vaccinia virus has evolved to subvert the host immune response publication-title: J Struct Biology doi: 10.1016/j.jsb.2011.03.010 – volume: 83 start-page: 4854 year: 2009 ident: ref16 article-title: The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection publication-title: J Virol doi: 10.1128/JVI.00187-09 – volume: 13 start-page: 223 year: 2012 ident: ref8 article-title: SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates publication-title: Nat Immunol doi: 10.1038/ni.2236 – volume: 18 start-page: 1682 year: 2012 ident: ref21 article-title: SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells publication-title: Nat Medicine doi: 10.1038/nm.2964 – volume: 8 start-page: 182 year: 2013 ident: ref1 article-title: Metabolic pathways as regulators of HIV infection publication-title: Current Opinion in HIV and AIDS doi: 10.1097/COH.0b013e32835fc53e – volume: 1799 start-page: 223 year: 2010 ident: ref54 article-title: Chromatin dynamics during herpes simplex virus-1 lytic infection publication-title: Biochimica Biophysica Acta doi: 10.1016/j.bbagrm.2010.01.012 – volume: 24 start-page: 414 year: 2011 ident: ref55 article-title: Nuclear delivery mechanism of herpes simplex virus type 1 genome publication-title: J Mole Recognition : JMR doi: 10.1002/jmr.1120 – volume: 279 start-page: 51545 year: 2004 ident: ref13 article-title: Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase publication-title: J Biol Chem doi: 10.1074/jbc.M408573200 – volume: 287 start-page: 21570 year: 2012 ident: ref6 article-title: Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages publication-title: J Biol Chem doi: 10.1074/jbc.C112.374843 – volume: 58 start-page: 27 year: 2008 ident: ref49 article-title: HSV-1 infection through inhibitory receptor, PILRalpha publication-title: Uirusu doi: 10.2222/jsv.58.27 – volume: 82 start-page: 12335 year: 2008 ident: ref17 article-title: Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells publication-title: J Virol doi: 10.1128/JVI.01181-08 – volume: 179 start-page: 247 year: 1990 ident: ref62 article-title: The complete DNA sequence of vaccinia virus publication-title: Virology doi: 10.1016/0042-6822(90)90294-2 – volume: 85 start-page: 12662 year: 2011 ident: ref44 article-title: The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-kappaB in dendritic cells in the absence of type I interferon signaling publication-title: J Virol doi: 10.1128/JVI.05557-11 – volume: 40 start-page: 456 year: 1981 ident: ref41 article-title: Control of expression of the vaccinia virus thymidine kinase gene publication-title: J Virol doi: 10.1128/JVI.40.2.456-464.1981 – volume: 246 start-page: 92 year: 2007 ident: ref57 article-title: Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II publication-title: Cell Immuno doi: 10.1016/j.cellimm.2007.06.005 – volume: 9 start-page: 105 year: 2012 ident: ref18 article-title: SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons publication-title: Retrovirology doi: 10.1186/1742-4690-9-105 – volume: 6 start-page: e15615 year: 2011 ident: ref25 article-title: Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus publication-title: PLoS One doi: 10.1371/journal.pone.0015615 – volume: 286 start-page: 43596 year: 2011 ident: ref10 article-title: The Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase publication-title: J Biol Chem doi: 10.1074/jbc.C111.317628 – volume: 41 start-page: 829 year: 2009 ident: ref23 article-title: Mutations involved in Aicardi-Goutieres syndrome implicate SAMHD1 as regulator of the innate immune response publication-title: Nat Genet doi: 10.1038/ng.373 – volume: 2 start-page: e132 year: 2006 ident: ref3 article-title: Dynamics of the cellular metabolome during human cytomegalovirus infection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.0020132 – volume: 6 start-page: e1000984 year: 2010 ident: ref42 article-title: Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis publication-title: PLoS Pathogens doi: 10.1371/journal.ppat.1000984 – volume: 8 start-page: 55 year: 2011 ident: ref40 article-title: SAMHD1: a new insight into HIV-1 restriction in myeloid cells publication-title: Retrovirology doi: 10.1186/1742-4690-8-55 – volume: 79 start-page: 4755 year: 2005 ident: ref33 article-title: Visualization and characterization of the intracellular movement of vaccinia virus intracellular mature virions publication-title: J Virol doi: 10.1128/JVI.79.8.4755-4763.2005 – volume: 436 start-page: 247 year: 2013 ident: ref15 article-title: Intracellular nucleotide levels and the control of retroviral infections publication-title: Virology doi: 10.1016/j.virol.2012.11.010 – volume: 23 start-page: 676 year: 1983 ident: ref43 article-title: Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine publication-title: Antimicrobial Agents and Chemotherapy doi: 10.1128/AAC.23.5.676 – volume: 6 start-page: 806 year: 2011 ident: ref35 article-title: A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors publication-title: Nat Protoc doi: 10.1038/nprot.2011.327 – volume: 56 Suppl 1 start-page: S56 year: 2012 ident: ref2 article-title: The interaction of metabolic factors with HCV infection: does it matter? publication-title: Journal of hepatology doi: 10.1016/S0168-8278(12)60007-5 – volume: 195 start-page: 732 year: 1993 ident: ref53 article-title: Nuclear localization of a double-stranded RNA-binding protein encoded by the vaccinia virus E3L gene publication-title: Virology doi: 10.1006/viro.1993.1424 – volume: 9 start-page: 1001 year: 2002 ident: ref37 article-title: Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers publication-title: Cancer Gene Therapy doi: 10.1038/sj.cgt.7700549 – volume: 9 start-page: 87 year: 2012 ident: ref20 article-title: SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells publication-title: Retrovirology doi: 10.1186/1742-4690-9-87 – volume: 30 start-page: 255 year: 1999 ident: ref28 article-title: Characteristics of a macrophage culture persistently infected with herpes simplex virus type 1 publication-title: Arch Med Res doi: 10.1016/S0188-0128(99)00021-4 – volume: 78 start-page: 1977 year: 1997 ident: ref30 article-title: Nitric oxide production induced by herpes simplex virus type 1 does not alter the course of the infection in human monocytic cells publication-title: J Gen Virol doi: 10.1099/0022-1317-78-8-1977 – volume: 288 start-page: 10406 year: 2013 ident: ref56 article-title: Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection publication-title: J Biol Chem doi: 10.1074/jbc.M112.443796 – volume: 61 start-page: 213 year: 1990 ident: ref66 article-title: HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure publication-title: Cell doi: 10.1016/0092-8674(90)90802-L – volume: 167 start-page: 47 year: 2012 ident: ref51 article-title: Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses publication-title: Clinical Exp Immuno doi: 10.1111/j.1365-2249.2011.04502.x – volume: 281 start-page: 13388 year: 2006 ident: ref11 article-title: Modification of human immunodeficiency virus type 1 reverse transcriptase to target cells with elevated cellular dNTP concentrations publication-title: J Biol Chem doi: 10.1074/jbc.M600291200
SSID	ssj0041316
Score	2.4730635
Snippet	SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid... SAMHD1 is a newly identified anti-HIV host factor that has a dNTP triphosphohydrolase activity and depletes intracellular dNTP pools in non-dividing myeloid...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e1003481
SubjectTerms	Biology Cell Line DNA viruses Enzymes Female Health aspects Herpesvirus 1, Human - physiology Host-parasite relationships Humans Hydrolases Infections Lymphocytes Male Medicine Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Myeloid Cells - metabolism Myeloid Cells - pathology Myeloid Cells - virology Pathogenesis Physiological aspects Proteins SAM Domain and HD Domain-Containing Protein 1 Vaccinia virus - physiology Virus Replication - physiology Viruses
SummonAdditionalLinks	– databaseName: Open Access: DOAJ - Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nj9MwELVQBRIXxPeGXZBBSJzCxonjj2NhqcqBCrEg7S2yYwcilaSq05X23-9MklYbBNoL13qiyOPx-E3jeY-QtxwwveKOx4kxPubKadhSKYuZMxV3UiXK2l5sQq5W6uJCf70h9YV3wgZ64MFxpyaDM75MhPFGcOk14F8oanJvRaqs1h6zbyL1vpgacjBk5l70FEVxYpkJMTbNZZKdjmv0frMxSB-dYCfq5FDqufsPGXq2Wbfhb_Dzz1uUN46lxUPyYMSTdD7M4xG545vH5N6gMHn1hCyWbejoIKpDz-dflmeMohoHZL8u0LPVnF7W213wgdYNbdom7tuz4Dijv6_8uq0dxX_2w1PyY_Hp-8dlPEonxKXQuou5Yw6AATOQ8ZwrlZVJlUJuk4Jr4ZWGsrAEIFXxUuVGptbLKjVQe3HrWeWczJ6RGbzUHxEqMw6Yx5aJdZbnzhjkqDfSSZ-lTNgkItned0U58oqjvMW66D-WSagvBlcU6PFi9HhE4sNTm4FX4xb7D7gsB1tkxe5_gFgpxlgpbouViLzBRS2Q96LBizU_zS6E4vP5qpjjB9a-DfmfRt8mRu9Go6qFyZZmbGYAlyGf1sTyZGIJu7ecDB9hgO3nHKAUA0CZA-6Fodf7oCvwKbwN1_h2BzaZVtgRLGREng9BeHAMQDCoaHMVETkJz4nnpiNN_avnFc-E5kqwF__D1cfkfjoIh8QJOyGzbrvzL8nd8rKrw_ZVv1mvAUwNQBA priority: 102 providerName: Directory of Open Access Journals
Title	Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells
URI	https://www.ncbi.nlm.nih.gov/pubmed/23825958 https://www.proquest.com/docview/1398434367 https://pubmed.ncbi.nlm.nih.gov/PMC3694861 https://doaj.org/article/a3545c06aea647e99748255eb628b99e http://dx.doi.org/10.1371/journal.ppat.1003481
Volume	9
WOSCitedRecordID	wos000321206600065&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: Directory of Open Access Journals (DOAJ) customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: DOA dateStart: 20050101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: M7P dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: 7X7 dateStart: 20050901 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: BENPR dateStart: 20050901 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: PIMPY dateStart: 20050901 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1553-7374 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0041316 issn: 1553-7374 databaseCode: FPL dateStart: 20050101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwELbYLkhceMMWlsogJE6BOHH9OHa3W3UlGkVdQMsp8itQqUqqpkXaf884SQtZUSEuOcRjyRmPx9_Enm8QekcB0wtqaRAq5QIqrIQlFZGAWJVTy0UotK6LTfAkEdfXMv0dKN46wY85-djq9MNqpTzdc-gzR4_QcRQz5oOtSfpp53nBHxPWpscd6tnZfmqW_r0v7q2WZfU3oHn7vuQfG9Dk4f8O_RF60EJNPGps4zG644on6F5TfPLmKZpMy2qDJ3W9HXw1mk3HBM-dL-NhNhUeJyP8dbHeVq7CiwInZRGMfeYW7HR4duOW5cLic7dcVs_Ql8nF5_Np0FZVCAyTchNQSyxgBqLAGVprhOZhHoHb44xK5oSEiNEAxsqpEUPFI-14HikIy6h2JLeWx89RrygLd4IwjynAIW1CbTUdWqU8fb3ilrs4IkyHfRTvlJ2ZlnLcV75YZvU5GofQo1FF5jWUtRrqo2Dfa9VQbvxD_szP417WE2bXL2Aqsnb9ZSoGqGhCppxilDsJYRTExkOnWSS0lK6P3noryDwlRuHv3HxX26rKLq-SbOTPXusM5YNC847Q-1YoL-FjjWrzHEBlnmqrI3nakYSFbTrNJ94id99cQZQGWHMIkBia3uysNPO9_EW5wpVbkIml8MnCjPfRi8Zq94oBdAbB7lD0Ee_Yc0dz3ZZi8aOmHI-ZpIKRl4eH9Ardj5pKIUFITlFvs9661-iu-blZVOsBOuLXvH6KATo-u0jS-aD-_TGoV_DAX7lNoSW9nKXffgHzVEEj
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeggMYL37DCAIOQeMqIEze2H8tK1Yk2mraB9mb5K6xSlVRNi7T_nnPiVgRR8cJbFJ8l-3w-_072_Q6hDxQwPaeWRrFSLqLcCthSCYmIVQW1jMdc66bYBMtzfnUlzgKlkM-FCRqEGHFR1c1Nvv-oSvcpaLK9OD0mKSNb4ePlUnkm6Ngnld5Gd5iAQ8gzPp5Nt04ZXDXJQubcvp6dk6kh8N-56Z4fxN8w6J9PKX87m8YP_-OsHqEHAaDiYdvjMbrlyifoXluy8uYpGk-qeo3HTZUefDGcTUYEnztf_MOsazzKh_j7fLWpXY3nJc6rMhr5fC84H_Hsxi2qucUnbrGon6Fv4y-XJ5Mo1GKITCbEOqKWWEAaRIELtdZwzeIiAWfJMioyxwXEmQaQWUENHyiWaMeKREEwR7UjhbUsfY56JUz4EGGWUgBR2sTaajqwSnnSe8Usc2lCMh33UbpdB2kCUbmvl7GQze0bg4ClVYX0GpJBQ30U7XotW6KOf8h_9ku8k_U0280PWB0ZVkWqFACmiTPlVEaZExB8QUQ9cDpLuBbC9dF7byDSE2mU_qXOD7Wpa3l6kcuhv7Ft8pr3Cp13hD4GoaKCyRoVsiNAZZ6gqyN51JEEd2A6zYfetrZzriG2A4Q6ACANTe-2Bix9L_-8rnTVBmRSwX2Kccb66EVr0DvFAKaDEHnA-4h1TL2juW5LOb9uiMrTTFCekZf7h_QWHUwuZ1M5Pc2_vkL3k7bWSBSTI9RbrzbuNbprfq7n9epNs51_AdtIUwo
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdG-RAvfMMKAwJC8JQtTlx_PJaVqhNbVG2A9jJFju1ApSqpmhRp_z13-agIouKJtyg-R_H5cv5d7PsdIe8YYHrJLPMDrZ3PpFXwSYXUp1ZnzAoZyDSti02IOJaXl2q-R666XJhWgxAjLouy3snHiyJ3R60mj5CvqNk9PaSRoF2Pw9VKIx10gJml72vGIfwzVmEC0g1yUygIZZAFcn7aOWpw35S32XS7HtRbrWpS_63rHuCL_Q2X_nm88rf1anr_P4_0AbnXAllv3DzlIdlz-SNyuyltef2YTGdFWXnTupqPdzE-m02od-6wSIipSm8Sj71vi_WmdKW3yL24yP0J5oXBOuqdXbtlsbDesVsuyyfk6_TTl-OZ39Zs8A1XqvKZpRYQCdXgaq01MhVBFoJTFZwp7qSCeNQAgsuYkSMtwtSJLNQQ9LHU0cxaET0lgxyUsE88ETEAW6kJUpuykdUayfG1sMJFIeVpMCRRNzeJaQnNsa7GMql36QQENo0qElRY0ipsSPxtr1VD6PEP-Y847VtZpOOub8CMJe1MJToCIGoCrp3mTDgFQRpE3iOX8lCmSrkheYtGkyDhRo4ner7rTVkmJxdxMsad3Tr_eafQeU_oQyuUFTBYo9ssClAZmktP8qAnCW7D9Jr30d66MZcQAwKSHQHghqY3nVEn2AuP4eWu2IBMpCSmInMxJM8aI98qBrAfhNIjOSSiZ_49zfVb8sWPmtA84opJTp_vfqXX5M58Mk1OT-LPL8jdsClJ4gf0gAyq9ca9JLfMz2pRrl_VX_gvABhiPw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Host+factor+SAMHD1+restricts+DNA+viruses+in+non-dividing+myeloid+cells&rft.jtitle=PLoS+pathogens&rft.au=Hollenbaugh%2C+Joseph+A&rft.au=Gee%2C+Peter&rft.au=Baker%2C+Jonathon&rft.au=Daly%2C+Michele+B&rft.date=2013-06-01&rft.pub=Public+Library+of+Science&rft.issn=1553-7366&rft.volume=9&rft.issue=6&rft_id=info:doi/10.1371%2Fjournal.ppat.1003481&rft.externalDocID=A350164391
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1553-7374&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1553-7374&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1553-7374&client=summon