A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to HIV progression could be a dysbiotic microbiome. We therefore hypothesized that the GI mucosal microbiome is altered in HIV patients and this alteration correlates with immune ac...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 10; no. 2; p. e1003829
Main Authors:	Mutlu, Ece A., Keshavarzian, Ali, Losurdo, John, Swanson, Garth, Siewe, Basile, Forsyth, Christopher, French, Audrey, DeMarais, Patricia, Sun, Yan, Koenig, Lars, Cox, Stephen, Engen, Phillip, Chakradeo, Prachi, Abbasi, Rawan, Gorenz, Annika, Burns, Charles, Landay, Alan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.02.2014 Public Library of Science (PLoS)
Subjects:	Antiretroviral drugs Bacteria Development and progression Disease Female Gastrointestinal system High-Throughput Nucleotide Sequencing Highly active antiretroviral therapy HIV HIV (Viruses) HIV infection HIV Infections - immunology HIV Infections - microbiology Human immunodeficiency virus Humans Illnesses Immune system Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Lymphocytes Male Medical research Medicine Medicine, Experimental Microbiota Microbiota (Symbiotic organisms) Middle Aged Mortality Physiological aspects Reverse Transcriptase Polymerase Chain Reaction RNA, Ribosomal, 16S - analysis HIV Infections Intestinal Mucosa Microbiota Humans Middle Aged Female Male High-Throughput Nucleotide Sequencing RNA, Ribosomal, 16S Reverse Transcriptase Polymerase Chain Reaction
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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