Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

The miR200 family regulates EMT through E-cadherin modulation and has been proposed to contribute to metastasis thusly. This report identifies a promoting role of miR-200 in metastatic colonization that involves a novel target, the tumor secretome. The correlation between miR-200 and metastasis in p...

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Veröffentlicht in:	Nature medicine Jg. 17; H. 9; S. 1101 - 1108
Hauptverfasser:	Korpal, Manav, Ell, Brian J, Buffa, Francesca M, Ibrahim, Toni, Blanco, Mario A, Celià-Terrassa, Toni, Mercatali, Laura, Khan, Zia, Goodarzi, Hani, Hua, Yuling, Wei, Yong, Hu, Guohong, Garcia, Benjamin A, Ragoussis, Jiannis, Amadori, Dino, Harris, Adrian L, Kang, Yibin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.09.2011 Nature Publishing Group
Schlagworte:	631/337/384/331 631/67/322 631/80/79/1902 692/699/67/1347 Animals Biomedical and Life Sciences Biomedicine Breast cancer Cadherins - metabolism Cancer Cancer Research Cell adhesion & migration Cell Line, Tumor Colonization Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - physiology Humans Infectious Diseases Mass Spectrometry Metabolic Diseases Metastasis Mice Mice, Inbred BALB C Microarray Analysis MicroRNAs - metabolism Molecular Medicine Neoplasm Metastasis - physiopathology Neurosciences Proteins Statistics, Nonparametric Vesicular Transport Proteins - metabolism United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online-Zugang:	Volltext
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