Serotonin Activates Bacterial Quorum Sensing and Enhances the Virulence of Pseudomonas aeruginosa in the Host

Bacteria in humans play an important role in health and disease. Considerable emphasis has been placed in understanding the role of bacteria in host-microbiome interkingdom communication. Here we show that serotonin, responsible for mood in the brain and motility in the gut, can also act as a bacter...

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Vydané v:	EBioMedicine Ročník 9; číslo C; s. 161 - 169
Hlavní autori:	Knecht, Leslie D., O'Connor, Gregory, Mittal, Rahul, Liu, Xue Z., Daftarian, Pirouz, Deo, Sapna K., Daunert, Sylvia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.07.2016 Elsevier
Predmet:	Advanced Basic Science Animals Bacterial Proteins - metabolism Catalase - metabolism Cytokines - analysis Female Host-microbiome interactions Injections, Intraperitoneal Interkingdom signaling molecule Internal Medicine Intestines - metabolism Intestines - microbiology Intestines - pathology Las pathway Malondialdehyde - metabolism Mice Mice, Inbred C57BL Microscopy, Electron, Scanning N-acyl homoserine lactone Peptide Hydrolases - metabolism Peroxidase - metabolism Phenotype Pregnancy Pseudomonas aeruginosa Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - metabolism Pseudomonas aeruginosa - physiology Quorum sensing Quorum Sensing - drug effects Research Paper Serotonin Serotonin - pharmacology Virulence - drug effects Serotonin Las pathway Pseudomonas aeruginosa Host-microbiome interactions Quorum sensing Interkingdom signaling molecule N-acyl homoserine lactone
ISSN:	2352-3964, 2352-3964
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