Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization
•Batch effects introduce significant confounding in multi-batch neuroimaging data.•Removal of batch effects is critical for reproducibility and generalizability.•We review current harmonization methods and describe common evaluation metrics.•We provide guidance to end-users on choosing an appropriat...
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| Vydáno v: | NeuroImage (Orlando, Fla.) Ročník 274; s. 120125 |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Elsevier Inc
01.07.2023
Elsevier Limited Elsevier |
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| ISSN: | 1053-8119, 1095-9572, 1095-9572 |
| On-line přístup: | Získat plný text |
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| Abstract | •Batch effects introduce significant confounding in multi-batch neuroimaging data.•Removal of batch effects is critical for reproducibility and generalizability.•We review current harmonization methods and describe common evaluation metrics.•We provide guidance to end-users on choosing an appropriate harmonization method.•We provide guidance to methodologists on current limitations and future directions.
Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field. |
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| AbstractList | Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field. Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field.Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field. Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field. •Batch effects introduce significant confounding in multi-batch neuroimaging data.•Removal of batch effects is critical for reproducibility and generalizability.•We review current harmonization methods and describe common evaluation metrics.•We provide guidance to end-users on choosing an appropriate harmonization method.•We provide guidance to methodologists on current limitations and future directions. Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called batch effects, is present in this data; direct application of downstream analyses to the data may lead to biased results. Image harmonization methods seek to remove these batch effects and enable increased generalizability and reproducibility of downstream results. In this review, we describe and categorize current approaches in statistical and deep learning harmonization methods. We also describe current evaluation metrics used to assess harmonization methods and provide a standardized framework to evaluate newly-proposed methods for effective harmonization and preservation of biological information. Finally, we provide recommendations to end-users to advocate for more effective use of current methods and to methodologists to direct future efforts and accelerate development of the field. |
| ArticleNumber | 120125 |
| Author | Davatzikos, Christos Shinohara, Russell T. Yu, Meichen Alexander-Bloch, Aaron Shou, Haochang Chen, Andrew A. Li, Mingyao Horng, Hannah Hu, Fengling Bashyam, Vishnu Satterthwaite, Theodore D. |
| AuthorAffiliation | f Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania, United States e Department of Child and Adolescent Psychiatry and Behavioral Science, Children’s Hospital of Philadelphia, United States h Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, United States d Penn-CHOP Lifespan Brain Institute, United States g The Penn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States c Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States a Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States b Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, United States |
| AuthorAffiliation_xml | – name: b Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, United States – name: g The Penn Lifespan Informatics and Neuroimaging Center, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States – name: f Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania, United States – name: a Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States – name: h Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, United States – name: d Penn-CHOP Lifespan Brain Institute, United States – name: c Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States – name: e Department of Child and Adolescent Psychiatry and Behavioral Science, Children’s Hospital of Philadelphia, United States |
| Author_xml | – sequence: 1 givenname: Fengling orcidid: 0000-0003-1081-5038 surname: Hu fullname: Hu, Fengling email: fengling.hu@pennmedicine.upenn.edu organization: Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States – sequence: 2 givenname: Andrew A. surname: Chen fullname: Chen, Andrew A. organization: Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States – sequence: 3 givenname: Hannah surname: Horng fullname: Horng, Hannah organization: Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States – sequence: 4 givenname: Vishnu surname: Bashyam fullname: Bashyam, Vishnu organization: Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, United States – sequence: 5 givenname: Christos surname: Davatzikos fullname: Davatzikos, Christos organization: Center for Biomedical Image Computing and Analytics (CBICA), Perelman School of Medicine, United States – sequence: 6 givenname: Aaron surname: Alexander-Bloch fullname: Alexander-Bloch, Aaron organization: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States – sequence: 7 givenname: Mingyao surname: Li fullname: Li, Mingyao organization: Statistical Center for Single-Cell and Spatial Genomics, Perelman School of Medicine, University of Pennsylvania, United States – sequence: 8 givenname: Haochang surname: Shou fullname: Shou, Haochang organization: Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States – sequence: 9 givenname: Theodore D. surname: Satterthwaite fullname: Satterthwaite, Theodore D. organization: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, United States – sequence: 10 givenname: Meichen surname: Yu fullname: Yu, Meichen organization: Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, United States – sequence: 11 givenname: Russell T. surname: Shinohara fullname: Shinohara, Russell T. organization: Penn Statistics in Imaging and Visualization Endeavor (PennSIVE), Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Dr, Philadelphia, PA 19104, United States |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37084926$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2023 Copyright © 2023. Published by Elsevier Inc. Copyright Elsevier Limited Jul 1, 2023 |
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| Snippet | •Batch effects introduce significant confounding in multi-batch neuroimaging data.•Removal of batch effects is critical for reproducibility and... Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex... Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex... |
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| SubjectTerms | Algorithms Benchmarking Biomarkers Brain - diagnostic imaging Brain - pathology Clinical trials Computed tomography Data collection Deep Learning Humans Machine learning Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical imaging Neuroimaging Neurosciences Reproducibility of Results Scanners Statistics |
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| Title | Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization |
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