Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized...

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Bibliographic Details
Published in:	PLoS genetics Vol. 7; no. 7; p. e1002198
Main Authors:	Sanna, Serena, Li, Bingshan, Mulas, Antonella, Sidore, Carlo, Kang, Hyun M., Jackson, Anne U., Piras, Maria Grazia, Usala, Gianluca, Maninchedda, Giuseppe, Sassu, Alessandro, Serra, Fabrizio, Palmas, Maria Antonietta, Wood, William H., Njølstad, Inger, Laakso, Markku, Hveem, Kristian, Tuomilehto, Jaakko, Lakka, Timo A., Rauramaa, Rainer, Boehnke, Michael, Cucca, Francesco, Uda, Manuela, Schlessinger, David, Nagaraja, Ramaiah, Abecasis, Gonçalo R.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.07.2011 Public Library of Science (PLoS)
Subjects:	Biology Cholesterol Cholesterol, LDL - genetics Chromosome Mapping Estimates European Continental Ancestry Group - genetics Genetic Loci - genetics Genetic Predisposition to Disease Genetic Variation Genetics Genome-Wide Association Study Genomes Humans Italy Low density lipoprotein Low density lipoproteins Physiological aspects Polymorphism, Single Nucleotide - genetics Volunteers Italy United States
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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